Acquired and Progressive Myelinated Nerve Fibers

Aaby, Aazy A.; Kushner, Burton J.

doi:10.1001/archopht.1985.01050040084024

Cited by 32 publications

(6 citation statements)

References 14 publications

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“…1 Of the 7 cases of acquired or progressive retinal nerve fiber layer myelination described in the literature, 3 have implicated processes that could cause a defect in the lamina cribrosa: direct ocular trauma, 5 hydrocephalus secondary to an Arnold-Chiari malformation, 3 and chronic papilledema from an arterial venous malformation. 2 While papilledema was never documented in either of our patients, the second patient had a history of increased intracranial pressure. We cannot exclude the possibility that papilledema was present at some point between examinations.…”

Section: Discussionsupporting

confidence: 40%

Acquired myelinated nerve fibers in association with optic disk drusen

Duval¹,

Hammamji²,

Aroichane³

et al. 2010

Journal of American Association for Pediatric Ophthalmology and

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Section: Discussionsupporting

confidence: 40%

Acquired myelinated nerve fibers in association with optic disk drusen

Duval¹,

Hammamji²,

Aroichane³

et al. 2010

Journal of American Association for Pediatric Ophthalmology and

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“…2-5 In contrast, the 10 reported cases of acquired MRNF in individuals <16 years of age, as was the present case, tended to be bilateral and associated with optic nerve abnormalities, hyperopia, esotropia, and good visual acuity. 1,6-11 …”

Section: Discussionmentioning

confidence: 99%

“…While a case of bilateral ONSF in a child that later led to bilateral acquired MRNF has been reported, 1 we are unaware of a case of unilateral ONSF leading to bilateral MRNF. This case plus a review of the literature on acquired MRNF in children suggest a possible mechanism for its occurrence.…”

mentioning

confidence: 86%

Acquired bilateral myelinated retinal nerve fibers after unilateral optic nerve sheath fenestration in a child with idiopathic intracranial hypertension

Prakalapakorn¹,

Buckley²

2012

Journal of American Association for Pediatric Ophthalmology and

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Purpose To report the unusual development of bilateral myelinated retinal nerve fibers (MRNF) adjacent to the optic nerve in a child after treatment of idiopathic intracranial hypertension (IIH) with unilateral optic nerve sheath fenestration (ONSF) and to discuss the etiology of acquired MRNF. Methods The patient’s clinical history, including visual acuity, refractive error, ocular alignment, fundus examination, and optic nerve photographs, was retrospectively reviewed. A literature review was performed for acquired MRNF in children using PubMed. The results of the demographic and clinical findings of our patient were compared with those of previously reported cases. Results The child developed bilateral MRNF adjacent to the optic nerve 5 months after unilateral ONSF. In reviewing the literature, 8 of 10 cases of acquired MRNF in children had prior abnormalities of the optic nerve, 4 of 10 had associated bilateral optic nerve head drusen, 3 of 10 had associated optic nerve glioma, and 3 of 10 had a history of significant increased intracranial pressure requiring surgical intervention. Conclusions While the etiology of acquired MRNF is uncertain, this case plus a review of the literature suggest that it may be related to changes in the lamina cribosa combined with possible optic nerve injury caused by optic nerve head drusen, optic nerve glioma, or elevated intracranial pressure, and that it can occur months to years after intervention.

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“…Although acquired and progressive nerve fiber myelination has been described previously, it is rare in the literature. 1,2 A 24-month-old fullterm boy with a history of high myopia was brought to the ophthalmology clinic. Cycloplegic spherical power was −10.00 diopters and −9.50 diopters in the right and left eye, respectively.…”

mentioning

confidence: 99%