Acquired bisalbuminemia in pancreatitis. Demonstration of a proteolytic process in ten patients.

Hereditary and acquired bisalbuminemia, in which the serum contains an albumin variant differing from albumin A by single amino-acid substitutions, have been reported in different races or ethnic groups and in association with various pathologic states. The importance of this rare condition in the pathophysiology of established diseases is uncertain. We evaluated a 68-year-old woman with chronic kidney disease who presented with worsened serum creatinine concentration despite lack of dietary or medical changes. Serum protein electrophoresis was performed with an automated rapid electrophoresis system. Bisalbuminemia was noted as an incidental finding on serum protein electrophoresis. The serum creatinine level stabilized with dietary protein restriction and a beta-blocking agent/diuretic combination for blood pressure control. Although the possibility that some physiologic or pharmacologic substances may not bind to abnormal albumin variants as well as they bind to normal albumin should not be discounted, the finding of bisalbuminemia did not influence the diagnosis, management, course, or prognosis of chronic kidney disease. The role of persistent bisalbuminemia in renal disease is uncertain.

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Bisalbuminemia in chronic kidney disease

Ejaz

Krishna

Wasiluk

et al. 2004

Clin Exp Nephrol

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Bisalbuminémie révélant une hyperparathyroïdie primaire avec faux kyste du pancréas fistulisé

Galezowski

Jouanique-Bayrod

Dazza

et al. 1997

La Revue de Médecine Interne

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Acquired bisalbuminemia in pancreatitis. Demonstration of a proteolytic process in ten patients.

Cited by 2 publications

References 4 publications

Bisalbuminemia in chronic kidney disease

Bisalbuminemia in chronic kidney disease

Bisalbuminémie révélant une hyperparathyroïdie primaire avec faux kyste du pancréas fistulisé

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