Acquired cutis laxa and multiple myeloma

Abstract

We report a patient with acquired cutis laxa and multiple myeloma, and the possible association between the two conditions is discussed.

Acquired cutis laxa following urticarial vasculitis associated with IgA myeloma

“…[13][14][15] Reports of CLA associated with multiple myeloma, plasmacytoid lymphoma, systemic lupus erythematosus, nephrotic syndrome with and without sarcoidosis, necrobiosis lipoidica, syphilis, and Lyme disease can be found in the literature. [16][17][18][19][20][21][22][23] There is one report of CL associated with aortitis in a 17-month-old girl. 24 However, to our knowledge, there are no reports of CLA associated with cutaneous vasculitis.…”

Generalized Cutis Laxa Associated with Heavy Chain Deposition Disease

“…10,11 Cutis laxa has been previously associated with multiple myeloma. 2,[12][13][14][15][16] This report discusses a patient who developed cutis laxa in association with heavy chain deposition disease, without evidence of a plasma cell dyscrasia.…”

“…18 In type I or generalized acquired elastolysis, the skin laxity often begins on the face and neck, with progressive development of generalized skin laxity in a cephalocaudad direction. 1,13 Rare cases may be localized, such as to the face, the ears, or the fingers and toes. 3,[19][20][21][22] Approximately half of acquired cases of cutis laxa are preceded by skin lesions, which may present with various morphologies, including erythematous plaques, edema, bullae, drug eruptions, erythema multiforme, urticaria, eczema, allergic reactions, or a dermatitis herpetiformis-like eruption.…”

“…4,21 Associations and Pathogenesis Acquired cutis laxa has been associated with several hematologic malignancies, including multiple myeloma, cutaneous B-cell lymphoma, and angiocentric T-cell lymphoma. 2,[12][13][14][15][16]33,34 Other reported associations include penicillin, penicillamine, or isoniazid therapy; diabetes mellitus; systemic amyloidosis; rheumatoid arthritis; celiac disease; and Borrelia burgdorferi infection. 1,3,15,22,[35][36][37][38][39][40][41] Finally, cutis laxa has been associated with renal changes, including diffuse glomerulosclerosis with arteriolar nephrosclerosis and nephrotic syndrome with membranoproliferative glomerulonephritis.…”

Congenital Cutis laxa

“…The acquired form is frequently associated with multiple myeloma [1], drug eruption [2], and erythema multiforme [3]. The congenital type is inherited as a severe autosomal recessive, a relatively benign, autosomal domi nant.…”