Acquired Dermal Melanocytosis Induced by Psoralen Plus Ultraviolet A Therapy

Nagase, Kotaro; Hirashima, Noriyuki; Koba, S; Inoue, Takuya; Misago, Noriyuki; Narisawa, Yutaka

doi:10.2340/00015555-1282

Cited by 7 publications

(7 citation statements)

References 8 publications

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“…The development of ADMs has been attributed to several causes. When the higher incidence of ADM among Asian descent is considered, genetic factors possibly play a crucial role . Four possible theories have been proposed about ADM's pathogenesis: migration of melanocytes from hair bulb to dermis, descendance of melanocytes from epidermis, reactivation of pre‐existing dormant dermal melanocytes or secondary development of DM caused by dermal inflammation .…”

Section: Atypical Variants and Presentations Of Dermal Melanocytosesmentioning

confidence: 99%

“…107 Four possible theories have been proposed about ADM's pathogenesis: migration of melanocytes from hair bulb to dermis, descendance of melanocytes from epidermis, reactivation of pre-existing dormant dermal melanocytes or secondary development of DM caused by dermal inflammation. 92 It is assumed that dermal melanocytes which are present since birth 108 are either activated by various triggering factors such as pregnancy, 92 trauma, 97 previous inflammatory dermatoses, 98,109 hormonal treatment 104 and PUVA therapy 107 or Table 4 Epidemiological, clinical and histological features of main patchy dermal melanocytoses 2,13,[51][52][53][54][55][56][57][58] Mongolian spot 13,[52][53][54][55][56] Naevus of Ota 2,51,54,57,58 Naevus of Ito 2,54 Epidemiology Asian, African American and Native American population Benign dermal dendritic melanocytic proliferations show a gradual increase in melanin synthesis by increasing age without a known aetiology. 108 Large plaque-type blue naevus with subcutaneous cellular nodules (LPTBN-SN)…”

Section: Main Localizationsmentioning

confidence: 99%

“…Four possible theories have been proposed about ADM's pathogenesis: migration of melanocytes from hair bulb to dermis, descendance of melanocytes from epidermis, reactivation of pre‐existing dormant dermal melanocytes or secondary development of DM caused by dermal inflammation . It is assumed that dermal melanocytes which are present since birth are either activated by various triggering factors such as pregnancy, trauma, previous inflammatory dermatoses, hormonal treatment and PUVA therapy or show a gradual increase in melanin synthesis by increasing age without a known aetiology …”

Section: Atypical Variants and Presentations Of Dermal Melanocytosesmentioning

confidence: 99%

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The spectrum of benign dermal dendritic melanocytic proliferations

Baykal

Yılmaz

Sun

et al. 2019

Acad Dermatol Venereol

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Dermal melanocytoses (DMs) comprise a heterogeneous group of benign lesions, located on skin and mucous membranes, characterized by dendritic melanocytes in the dermis. Although they share common histopathological features, some variants may present only as bluish or grey patches, some only as papules/nodules/plaques and others may show combination of all of these lesions. Despite the fact that blue naevus (BN) is typically characterized with papulonodular lesions, its variants may show all of the aforementioned presentations. Mongolian spot, naevus of Ota and naevus of Ito are patchy DMs distinguished by their specific localizations. Apart from these classical forms, many atypical variants without unique clinicopathological characteristics have been described in the literature making the nomenclature of DMs more complicated. However, congenital dermal melanocytosis and acquired dermal melanocytosis seem to be crucial umbrella terms that encompass all patchy DMs in atypical locations. Papules or subcutaneous nodules on patchy lesions and association of epidermal pigmentation presenting as brownish patches may be encountered as rare features of DMs. On the other hand, delayed‐onset subcutaneous nodules may be typical presentations of melanoma in patchy DMs; therefore, they deserve special attention. Large plaque‐type BN with subcutaneous cellular nodules is a newly described entity, harbouring clinical features of various DMs together and has a high risk of melanoma. The whole spectrum of dermal dendritic melanocytic proliferations is discussed including novelties and controversial issues.

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Section: Atypical Variants and Presentations Of Dermal Melanocytosesmentioning

confidence: 99%

Section: Main Localizationsmentioning

confidence: 99%

Section: Atypical Variants and Presentations Of Dermal Melanocytosesmentioning

confidence: 99%

See 1 more Smart Citation

The spectrum of benign dermal dendritic melanocytic proliferations

Baykal

Yılmaz

Sun

et al. 2019

Acad Dermatol Venereol

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“…234 Acquired dermal melanocytosis typically affecting the back of Japanese patients treated with PUVA has been reported. 326,327 PUVA can result in dose-related premature ageing of the skin, manifesting as wrinkling, xerosis, loss of elasticity, freckling, telangiectasia, mottled pigmentation, yellowing of the skin and comedones. More marked changes are seen in those of skin type I/II.…”

Section: Psoralen-ultraviolet a Therapy-induced Skin Cancermentioning

confidence: 99%

British Association of Dermatologists and British Photodermatology Group guidelines for the safe and effective use of psoralen–ultraviolet A therapy 2015

et al. 2016

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“…7,8 The conventional formulations of psoralen, such as tinctures and ointments, have weak percutaneous permeability and poor deposition in the skin, which usually leads to frequent administration and may cause adverse reactions. 9,10 Topical delivery of drugs by liposomal formulations has attracted considerable interest in recent decades because of the improved therapeutic effects. However, conventional liposomes do not permeate deeply into the skin.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of psoralen ethosomes for topical delivery in rats by using in vivo microdialysis

Zhang

Shen

Zhao

2014

IJN

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This study aimed to improve skin permeation and deposition of psoralen by using ethosomes and to investigate real-time drug release in the deep skin in rats. We used a uniform design method to evaluate the effects of different ethosome formulations on entrapment efficiency and drug skin deposition. Using in vitro and in vivo methods, we investigated skin penetration and release from psoralen-loaded ethosomes in comparison with an ethanol tincture. In in vitro studies, the use of ethosomes was associated with a 6.56-fold greater skin deposition of psoralen than that achieved with the use of the tincture. In vivo skin microdialysis showed that the peak concentration and area under the curve of psoralen from ethosomes were approximately 3.37 and 2.34 times higher, respectively, than those of psoralen from the tincture. Moreover, it revealed that the percutaneous permeability of ethosomes was greater when applied to the abdomen than when applied to the chest or scapulas. Enhanced permeation and skin deposition of psoralen delivered by ethosomes may help reduce toxicity and improve the efficacy of long-term psoralen treatment.

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Acquired Dermal Melanocytosis Induced by Psoralen Plus Ultraviolet A Therapy

Cited by 7 publications

References 8 publications

The spectrum of benign dermal dendritic melanocytic proliferations

The spectrum of benign dermal dendritic melanocytic proliferations

British Association of Dermatologists and British Photodermatology Group guidelines for the safe and effective use of psoralen–ultraviolet A therapy 2015

Evaluation of psoralen ethosomes for topical delivery in rats by using in vivo microdialysis

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