Acquired disorders of elastic tissue: part I. increased elastic tissue and solar elastotic syndromes

Lewis, Kevan G.; Bercovitch, Lionel; Dill, Sara W; Robinson‐Bostom, Leslie

doi:10.1016/j.jaad.2004.03.013

Cited by 173 publications

(202 citation statements)

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“…3 In 1955, Miescher found elastin in the material eliminated transepidermally and suggested the name of elastoma intrapapillare perforans verruciforme. 1 It was given the current denomination of elastosis perforans serpiginosa in 1958 by Dammert and Putkonen. 3 The incidence of EPS has yet to be established.…”

Section: Discussionmentioning

confidence: 99%

“…8 EPS is classified into three types: 1) idiopathic; 2) reactive, associated in 25% of cases with connective tissue diseases such as Ehlers-Danlos syndrome, cutis laxa, Marfan syndrome, pseudoxanthoma elasticum and osteogenesis imperfecta among others, as well as Down's syndrome; and 3) induced by D-penicillamine. 1 The association between EPS and Down's syndrome is unknown; however, factors present in this syndrome such as premature skin aging, joint hyperelasticity and acrocyanosis may suggest an underlying connective tissue disorder. 1,2 table 1 illustrates some clinical and epidemiological features of the association between EPS and Down's syndrome.…”

Section: Discussionmentioning

confidence: 99%

“…It is normally associated with hereditary diseases of the connective tissue and with the use of D-penicillamine for Wilson disease, cystinuria and rheumatoid arthritis. 1,2 It is characterized clinically by papules and keratotic, desquamative, normochromic or erythematous plaques, usually affecting the face, neck, trunk and upper limbs. 1,2 Histopathology is the gold-standard test for diagnosis, typical findings consisting of qualitative and quantitative changes in dermal elastic fibers and their transepidermal elimination.…”

Section: Introductionmentioning

confidence: 99%

“…1,2 It is characterized clinically by papules and keratotic, desquamative, normochromic or erythematous plaques, usually affecting the face, neck, trunk and upper limbs. 1,2 Histopathology is the gold-standard test for diagnosis, typical findings consisting of qualitative and quantitative changes in dermal elastic fibers and their transepidermal elimination. 3 There is no standard therapy; however, successful treatment has been reported with the use of cryotherapy with liquid nitrogen, isotretinoin, tazarotene, imiquimod and CO 2 , Er:YAG and pulsed dye lasers.…”

Section: Introductionmentioning

confidence: 99%

“…[4][5][6] In a minority of cases, spontaneous resolution of lesions has been reported. 1 report describes the case of a patient with Down's syndrome who has had EPS for the past five years.…”

Section: Introductionmentioning

confidence: 99%

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Elastose perfurante serpiginosa em portadora da síndrome de Down

Pereira

Baeta

Júnior

et al. 2010

An. Bras. Dermatol.

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Elastosis perforans serpiginosa is a rare, primary perforating dermatosis, frequently associated with certain genetic diseases and characterized by the transepidermal extrusion of elastic fibers. The present case report describes this dermatosis in a 19-year old female patient with Down's syndrome, who presented with asymptomatic erythematous, keratotic papules in an arciform pattern, located on her right forearm and knee, which had been present for five years. Following histopathological confirmation, treatment with cryotherapy was initiated, resulting in partial remission of the lesions. Keywords: Conjunctive tissue; Down's syndrome; Elastic tissue; Elastic tissue abnormalities Resumo: A elastose perfurante serpiginosa é dermatose perfurante primária incomum, frequentemente associada a determinadas doenças genéticas e caracterizada por eliminação transepidérmica de fibras elásticas. Relata-se um caso raro dessa dermatose em paciente feminina de 19 anos, portadora da sín-drome de Down, que apresentava pápulas eritematoceratóticas em arranjo arciforme, localizadas no antebraço e joelho direitos, assintomáticas, com cinco anos de evolução. Após confirmação histopatológica, foi iniciado tratamento com crioterapia, ocorrendo remissão parcial das lesões.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Elastose perfurante serpiginosa em portadora da síndrome de Down

Pereira

Baeta

Júnior

et al. 2010

An. Bras. Dermatol.

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Acquired Disorders of Dermal Connective Tissue

Lovell

2016

Rook's Textbook of Dermatology, Ninth Edition

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The subject matter of this chapter comprises the major acquired disorders that affect mainly collagen and elastic tissue. The connective tissue of normal skin is discussed elsewhere. Heritable disorders of connective tissue, such as Ehlers–Danlos syndrome, are covered in another chapter, as are disorders of ground substance, such as the mucinoses and mucopolysaccharidoses. In addition, many disorders, including developmental defects, neoplasms and other reactive or scarring conditions, may involve the connective tissues. Although it can be convenient to separate conditions into disorders affecting collagen or elastic tissue, the distinction is somewhat artificial, as changes in these proteins are generally preceded by abnormal metabolism of other matrix components, such as fibronectin or periostin.

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