Acquired Disorders of Hemostasis

Chalmers, Elizabeth; Williams, Michael D.; Thomas, Angela

doi:10.1002/9780470987001.ch29

Cited by 3 publications

(1 citation statement)

References 196 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Children with severe liver disease commonly have a coagulation disorder, caused by impaired synthesis of coagulation factors and clearance of activated clotting factors, enhanced fibrinolysis and there can also be an acquired platelet function defect. However, the liver has large reserves so often only 10–15% of children have significant bleeding (Chalmers & Gibson, 2000). Acquired dys‐ or hypo‐fibrinogenaemia can occur in some systemic diseases in childhood, including renal or liver disease, and following drug therapy, for example l ‐asparaginase and sodium valproate (Roberts et al , 2001).…”

Section: Acquired Disorders Of Coagulation and Platelet Functionmentioning

confidence: 99%

Bruising and bleeding in infants and children – a practical approach

Khair¹,

Liesner²

2006

Br J Haematol

View full text Add to dashboard Cite

SummaryBruising and bleeding are commonly seen in children and are usually associated with minor injury and trauma. However, in two groups of children the bruising may be more significant than expected: those with an underlying haemostatic abnormality, such as an inherited bleeding disorder, or those who have been subjected to non-accidental injury (NAI). Diagnosing inherited bleeding disorders in children is fraught with difficulty, from venous access to interpretation of results; the possibility of NAI should be borne in mind, even in those children with proven significant bleeding disorders when the severity of the injury and the history are non-compatible. We describe the investigation of the haemostatic system in children with bruising and/or bleeding with emphasis on the key haemostatic disorders that need to be excluded.

show abstract

Section: Acquired Disorders Of Coagulation and Platelet Functionmentioning

confidence: 99%

Bruising and bleeding in infants and children – a practical approach

Khair¹,

Liesner²

2006

Br J Haematol

View full text Add to dashboard Cite

show abstract

Postneonatal Vitamin K Deficiency

Scott¹,

Montgomery²

2011

Nelson Textbook of Pediatrics

View full text Add to dashboard Cite

Acquired von Willebrand disease: from theory to practice. A single center experience - three case reports

Coliţă

Șaguna

Costache

et al. 2016

Revista Romana De Medicina De Laborator

View full text Add to dashboard Cite

Acquired von Willebrand disease (AvWD) represents a rare, potentially severe and most likely underdiagnosed category of hemorrhagic syndromes determined by quantitative, qualitative or functional, nonhereditary, alterations of von Willebrand factor (vWF) that occur in the context of various underlying diseases. It is diagnosed mainly in adults, without any personal or familial history of bleeding. The etiopathogeny of AvWD is complex, marked by the intervention of multiple mechanisms, occuring in the evolution of neoplasia, autoimmune disorders, cardiovascular diseases and other conditions. The clinical and laboratory manifestations are similar to the congenital form with mucocutaneous hemorrhage in patients without bleeding history and demonstration of quantitative and/or functional anomalies of vWF. Treatment has two major objectives: control of bleeding and therapy of the underlying condition. As a practical illustration of the theoretical aspects we present 3 clinical cases of AvWD diagnosed in the Colţea Hospital Department of Hematology during the last 10 years.

show abstract

Acquired Disorders of Hemostasis

Cited by 3 publications

References 196 publications

Bruising and bleeding in infants and children – a practical approach

Bruising and bleeding in infants and children – a practical approach

Postneonatal Vitamin K Deficiency

Acquired von Willebrand disease: from theory to practice. A single center experience - three case reports

Contact Info

Product

Resources

About