Acquired hypertrichosis lanuginosa: Case report and review of the literature

Clinical and pathologic findings of paraneoplastic dermatoses

“…100 Approximately 50 cases have been reported in the literature since. 101 Hypertrichosis lanuginosa can occur as a congenital autosomal dominant form, in which there is a generalized persistence of fetal lanugo hair, and may be associated with deformities of the external ears and teeth. By contrast, the sudden appearance of lanugo hair later in life may signal malignancy.…”

“…Associated noncutaneous signs include glossitis, papillary hypertrophy of the tongue, and weight loss. 101 Histologic features. Most of the lanugo hair follicles deviate from the normal vertical position and extend almost parallel to the epidermal surface.…”

“…105 These structures are also described as containing immature sebocytes within the mantle epithelium. 101 Internal malignancy. Hypertrichosis lanuginosa acquisita is strongly associated with malignancy.…”

“…Other reported cancers include those of the ovaries, uterus, bladder, gallbladder, pancreas, and kidney, and leukemia. 101 Timing and course. Hypertrichosis lanuginosa acquisita usually appears late in the course of the malignancy, after the tumor has spread widely, 106 but this dermatosis may also presage development of the tumor.…”

Hypertrichose

“…Auch bei Encephalomyelitis disseminata (multipler Sklerose) wurde über symptomatische Hypertrichosen berichtet.Hypertrichosis lanuginosa acquisita. Es handelt sich um eine seltene obligate Paraneoplasie mit plötzlich einsetzendem, erheblich verstärktem Wachstum von Lanugohaaren, zunächst im Gesicht, auf der Nase, der Stirn und im Bereich des Nackens und oberen Rückens[6]. Das Einzelhaar kann bis zu 4 cm lang werden.…”