Acquired pure red cell aplasia

Ammus, Sharhabil S.; Yunis, Adel A.

doi:10.1002/ajh.2830240312

Cited by 69 publications

(30 citation statements)

References 162 publications

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“…Other treatment modalities used successfully include azathioprine, cyclophosphamide, antithymocytic globulin, high-dose IV immunoglobulin, cyclosporin and plasmapheresis [15]. Corticosteroids and other immunomodulating drugs are also used for AOSD.…”

Section: Discussionmentioning

confidence: 99%

Pure red cell aplasia and adult-onset Still’s disease

et al. 2004

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Section: Discussionmentioning

confidence: 99%

Pure red cell aplasia and adult-onset Still’s disease

et al. 2004

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“…The present patient was considered to belong to acquired chronic PRCA which is an unusual disease occurring mostly in adults. PRCA can be induced by certain drugs (4,5), and most of these cases recovered quickly when the drug was stopped (5). The present patient received only prednisolone and mucolytic agents for eosinophilic pneumonia, but his anemia progressed after the ter mination of drugs.…”

Section: Discussionmentioning

confidence: 99%

Acquired Chronic Pure Red Cell Aplasia Successfully Treated with Intravenous Pulse Methylprednisolone Therapy.

et al. 1992

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A 65-year-old male patient developed acquired chronic pure red cell aplasia (PRCA) associated with hypergammaglobulinemia and positive Coombs' test during the treatment of eosinophilic pneumonia with prednisolone (PSL). His PRCA was treated with oral PSL at a dose of 60 mg/day for 3 weeks, but anemia further progressed. Immediately after high-dose intravenous pulse methylprednisolone therapy (l g/day for 3 days) however, reticulocyte crisis ocurred and his anemia rapidly improved. He has been in complete remission under a maintenance dose of PSL for more than 2 years. This patient indicates that high-dose intravenous methylprednisolone therapy is one of the useful treatments, not only for consti tutional PRCA, but also for acquired chronic PRCA.

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“…The pathophysiology of PRCA is not completely known but may be related to abnormal T cell function and the presence of IgG antibodies which target erythroblasts and erythropoietin 4 . Usually 30 to 50 percent of patients with red-cell aplasia have thymomas 1 .…”

Section: Discussionmentioning

confidence: 99%

“…Red-cell aplasia is a rare disorder that results in a severe normochromic normocytic anaemia and it occurs only in 5 percent of patients with thymomas as a paraneoplastic syndrome 1 . We report a case of thymoma associated with pure red cell aplasia (PRCA) where initial remission of anaemia occur after thymectomy only.…”

Section: Introductionmentioning

confidence: 99%