Acquired resistance to the human hookworm <i>Necator americanus</i> in mice

Wells, Catherine; Behnke, Jerzy M.

doi:10.1111/j.1365-3024.1988.tb00238.x

Cited by 13 publications

(8 citation statements)

References 28 publications

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“…There were no significant differences between the weights of control and infected groups in Exp. 3. been shown to occur in the case of N. americanus in mice (Wells & Behnke, 1988). Despite finding an occasional larva in the musculature we concluded that significant tissue migration was unlikely to have occurred following oral exposure to the parasite.…”

Section: Discussionmentioning

confidence: 67%

Ancylostoma ceylanicum in the hamster: observations on the host—parasite relationship during primary infection

Garside

Behnke

1989

Parasitology

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Section: Discussionmentioning

confidence: 67%

Ancylostoma ceylanicum in the hamster: observations on the host—parasite relationship during primary infection

Garside

Behnke

1989

Parasitology

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“…There is no robust experimental animal model that parallels the course of hookworm infection in humans. Human hookworm species do not mature in mice . Hamsters are (at best) a semi‐permissive host to these species and, although they can be infected with N. americanus , the infection time is much shorter and the worm burden much lower than in humans .…”

Section: Introductionmentioning

confidence: 99%

Immunology of experimental and natural human hookworm infection

Gaze

Bethony

Periago

2014

Parasite Immunology

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Human hookworm infection is one amongst the most prevalent of the neglected tropical diseases. An informative experimental animal model, that is, one that parallels a human infection, is not available for the study of human hookworm infection. Much of our current understanding of the human immune response during hookworm infection relies on the studies from experimental infection of hookworm-naïve individuals or the natural infections from individuals residing in hookworm-endemic areas. The experimental human infections tend to be acute, dose-controlled infections, often with a low larval inoculum so that they are well tolerated by human volunteers. Natural hookworm infections usually occur in areas where hookworm transmission is constant and infection is chronic. In cases where there has been drug administration in an endemic area, re-infection often occurs quickly even amongst those who were treated. Hence, although many of the characteristics of experimental and natural hookworm infection differ, both models have elements in common: mainly an intense Th2 response with the production of total and specific IgE as well as elevated levels of eosinophilia, IL-5, IL-10 and TNF. While hookworm infection affects millions of individuals worldwide, much of the human immunology of this infection still needs to be studied and understood.

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“…Despite H. polygyrus bakeri does not infect through the skin or migrate through the lungs (as it depends on oral ingestion of infective larvae), it has been extensively employed as a model for human hookworm infections. Indeed, similarly to hookworms, H. polygyrus bakeri induces chronic intestinal infections in several mice strains, and the modified Th2 cell responses induced by infection (a Th2-like response linked with the production of anti-inflammatory cytokines and Treg activity) does not completely eliminate the parasites (Wells and Behnke, 1988;Maizels, 2005;Bungiro et al, 2008;Reynolds et al, 2012;Nair and Herbert, 2016). Furthermore, the study of H. polygyrus bakeri and N. brasiliensis infection in rodents has provided the immunology community with important information about the humoral and cellular mechanisms involved in the induction and development of Th2 immune responses and their capacity in protecting against helminth infections (Ogilvie and Jones, 1971;Ishizaka et al, 1976;Urban et al, 1991;Camberis et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Rodent Models for the Study of Soil-Transmitted Helminths: A Proteomics Approach

Montaño

Cuéllar

Sotillo

2021

Front. Cell. Infect. Microbiol.

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Soil-transmitted helminths (STH) affect hundreds of millions worldwide and are some of the most important neglected tropical diseases in terms of morbidity. Due to the difficulty in studying STH human infections, rodent models have become increasingly used, mainly because of their similarities in life cycle. Ascaris suum and Trichuris muris have been proven appropriate and low maintenance models for the study of ascariasis and trichuriasis. In the case of hookworms, despite most of the murine models do not fully reproduce the life cycle of Necator americanus, their proteomic similarity makes them highly suitable for the development of novel vaccine candidates and for the study of hookworm biological features. Furthermore, these models have been helpful in elucidating some basic aspects of our immune system, and are currently being used by numerous researchers to develop novel molecules with immunomodulatory proteins. Herein we review the similarities in the proteomic composition between Nippostrongylus brasiliensis, Heligmosomoides polygyrus bakeri and Trichuris muris and their respective human counterpart with a focus on the vaccine candidates and immunomodulatory proteins being currently studied.

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Acquired resistance to the human hookworm Necator americanus in mice

Cited by 13 publications

References 28 publications

Ancylostoma ceylanicum in the hamster: observations on the host—parasite relationship during primary infection

Ancylostoma ceylanicum in the hamster: observations on the host—parasite relationship during primary infection

Immunology of experimental and natural human hookworm infection

Rodent Models for the Study of Soil-Transmitted Helminths: A Proteomics Approach

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