Acquired unilateral vitiligo and poliosis of the head and subacute encephalitis with partial recovery

Nellhaus, Gerhard

doi:10.1212/wnl.20.10.965

Cited by 36 publications

(27 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Inflammatory disorders that affect the nervous system, such as leprosy, syphilis and pinta [1], may manifest as cutaneous and hair hypopigmentation or depigmentation. In other cases, vitiligo appears in association with central nervous system symptoms caused by encephalitis and peripheral nerve injury [6]; the arrest of these symptoms is followed by repigmentation [7]. In other cases, vitiligo appears in association with central nervous system symptoms caused by encephalitis and peripheral nerve injury [6]; the arrest of these symptoms is followed by repigmentation [7].…”

Section: Introductionmentioning

confidence: 99%

The occurrence of cutaneous nerve endings and neuropeptides in vitiligo vulgaris: a case-control study

et al. 1996

View full text Add to dashboard Cite

Pioneering studies both in humans and animals have demonstrated an association between the peripheral nervous system and epidermal melanocyte destruction. The presence of certain neuropeptides and neuronal structural markers in peripheral nerve fibres was investigated in involved and uninvolved vitiligo skin and compared with normal healthy skin. A group of 18 vitiligo vulgaris patients and matched healthy volunteers participated in the investigation. The indirect immunofluorescence technique was employed. There was a tendency for a reduction in the number and intensity of low affinity (p75) nerve growth factor receptor immunoreactive (NGFr-IR) basal keratinocytes in involved vitiliginous skin (P < 0.06) compared with control skin, while the number of NGFr-IR nerve fibres was significantly increased (P < 0.01). The number of calcitonin gene-related peptide (CGRP)-IR nerve fibres in the epidermis and papillary dermis was dramatically increased in involved skin as compared with control skin (P < 0.01) and with uninvolved skin (P < 0.05). No clear difference could be found in the distribution of vasoactive intestinal polypeptide (VIP)- and neuropeptide tyrosine (NPY)-IR nerve fibres. A different structural appearance of the peripheral nervous system as well as a changed balance of neuropeptides in vitiliginous skin point to a critical role of the nervous system in the pathogenesis of vitiligo.

show abstract

Section: Introductionmentioning

confidence: 99%

The occurrence of cutaneous nerve endings and neuropeptides in vitiligo vulgaris: a case-control study

et al. 1996

View full text Add to dashboard Cite

show abstract

“…Several lines of evidence support the neuronal mechanism in the pathogenesis of SV. Study has found that skin became depigmented in areas corresponding to local neurological damage (e.g., subacute encephalitis, spinal cord tumors, or following trauma) . Abnormal sympathetic nerve functions (e.g., acetylcholine activity and catecholamine metabolism) were observed in the SV‐affected skin, and α ‐ and β ‐adrenoceptor responses were increased in SV lesions .…”

Section: Discussionmentioning

confidence: 99%

Motor nerve conduction velocity is affected in segmental vitiligo lesional limbs

Zhou

Zhong

et al. 2016

Int J Dermatology

View full text Add to dashboard Cite

To evaluate the effects of segmental vitiligo (SV) on nerve conduction velocity (NCV) in different nerves, we compared the patient's lesional side of their body to the contralateral normal side. The 106 participants were selected from outpatients visiting the dermatological clinics of Huashan Hospital, Fudan University, from November 2011 to March 2014. NCVs were measured on the limbs and the face, including both motor and sensory nerves. The parameters for NCVs included motor nerve conduction velocity (MCV) and its distal conduction latency, sensory nerve conduction velocity, sensory nerve action potentials amplitude, and compound muscle action potential amplitude. MCV on the limbs was compromised by SV state, which was significantly slower on the lesional side of the body compared with the normal contralateral side (P = 0.006). Furthermore, SV at the stable stage significantly impaired MCV compared with the SV at progressive stage. There was no significant difference in the other parameters of NCV between lesional and normal sides of the body. Compound muscle action potentials in the face did not differ between lesional and healthy sides. Motor nerves in the limbs were compromised by SV, particularly when the disease was at the stable stage.

show abstract

“…Nellhaus (1970) reported the case of a 4 year old girl with a six month history of left facial vitiligo and greying of the hair, aphasia, right hemiparesis, mental deterioration, and right hemiconvulsions.…”

Section: Discussionmentioning

confidence: 99%

Neurological complications of progressive facial hemiatrophy

Wolf

Verity

1974

Journal of Neurology, Neurosurgery & Psychiatry

View full text Add to dashboard Cite

Acquired unilateral vitiligo and poliosis of the head and subacute encephalitis with partial recovery

Cited by 36 publications

References 5 publications

The occurrence of cutaneous nerve endings and neuropeptides in vitiligo vulgaris: a case-control study

The occurrence of cutaneous nerve endings and neuropeptides in vitiligo vulgaris: a case-control study

Motor nerve conduction velocity is affected in segmental vitiligo lesional limbs

Neurological complications of progressive facial hemiatrophy

Contact Info

Product

Resources

About