Acquired ventricular septal defect due to infective endocarditis

Durden, Randi E; Turek, Joseph W.; Reinking, Benjamin E.; Bansal, Manish

doi:10.4103/apc.apc_130_17

Cited by 9 publications

(6 citation statements)

References 7 publications

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“…Acquired VSD secondary to IE is rare and there are only a few such cases reported [ 4 , 5 ]. This case is novel in which the patient had persistent clinical signs and symptoms of IE and subsequently developed VSD despite expedient antimicrobial therapy with resultant negative blood culture and absence of vegetation in multiple echocardiography including a TOE.…”

Section: Discussionmentioning

confidence: 99%

“…While other strains of Staphylococcus spp. have been reported to cause IE with acquired VSD [ 5 ], to the authors’ knowledge, along with a literature review of acquired VSDs in IE, there has not been any reported case associated with PVL-producing S. aureus .…”

Section: Discussionmentioning

confidence: 99%

“…IE can result in various complications including septic emboli of the lungs, intracerebral abscess and splenic or digital infarction secondary to septic emboli, as well as septic embolisation to the brain which is commonly observed in S. aureus IE [ 1 , 3 ]. Another rare complication of IE is acquired ventricular septal defect (VSD) which has been occasionally reported since its first description in 1878 [ 4 , 5 ]. This article describes a case of acquired VSD secondary to IE caused by S. aureus that produces Panton-Valentine leukocidin (PVL) which is known to cause tissue necrosis [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

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Acquired Ventricular Septal Defect in Panton-Valentine Leukocidin-Positive Staphylococcus aureus Infective Endocarditis

Yeap,

Garner,

Sturridge

2023

Cureus

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Infective endocarditis (IE) is life-threatening and can lead to complications if left untreated. A 56-year-old gentleman presented with acute delirium, fever and rigor. Panton-Valentine leukocidin (PVL)-positive Staphylococcus aureus ( S. aureus ) was isolated in the blood culture and the PR interval was prolonged on the electrocardiogram (ECG). However, the transthoracic echocardiogram (TTE) and transoesophageal echocardiogram (TOE) at presentation were unremarkable with no evidence of intracardiac vegetations. Despite expedient intravenous antibiotics, an acquired ventricular septal defect (VSD) developed, which required urgent cardiothoracic surgical repair. It is imperative to consider early surgical interventions and the use of anti-toxin antibiotics in PVL-positive S. aureus IE.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Acquired Ventricular Septal Defect in Panton-Valentine Leukocidin-Positive Staphylococcus aureus Infective Endocarditis

Yeap,

Garner,

Sturridge

2023

Cureus

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“…Several genetic factors have been identified to cause VSD including chromosomal, a single gene, and polygenic inheritance. 7,8 Pinto et al 9 stated that isolated VSD accounts for 37% of all congenital heart disease in children. The incidence of isolated VSD is about 0.3% of newborns.…”

Section: Cont Table 1: Subjects Characteristicsmentioning

confidence: 99%

Clinical Profile of Pediatric Patients with Acyanotic Congenital Heart Disease in Dr. Soetomo General Hospital Surabaya

Kartika Hardiyani,

Taufiq Hidayat,

Alit Utamayasa

et al. 2021

Indian Journal of Forensic Medicine & Toxicology

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Congenital Heart Diseases (CHD) are classified as Acyanotic or Cyanotic CHD. Prevalence of CHD according to various studies is 8-10 per 1000 live births worldwide, 10% of cases became infant mortality in developing countries. This research aims to study the characteristics and clinical presentations in children with acyanotic CHD in Dr. Soetomo General Hospital. A retrospective observational study from children with acyanotic type of CHD from medical record outpatient clinic in the Division of Neonatology and Pediatric Ward at Dr. Soetomo General Hospital from June to December 2016. Age, sex, heart defect, comorbid and nutritional status were taken from the medical record. The most dominant clinical profile was female with a mean age of 4 years. Atrial Septal Defect was the most common type of left-to-right shunt, followed by Ventricular Septal Defect, and Patent Ductus Arteriosus. Pulmonary Stenosis was the most common type of obstructive lesion, followed by Aortic Stenosis. Complications of acyanotic CHD were dominated by recurrent respiratory tract infections followed by growth and developmental disorder, and heart failure. The most common nutritional status was moderate malnutrition.

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“…Another potential complication of IE can be the formation of ventricular septal defect due to the infection's aggressiveness which can show communication between the right ventricle and left ventricle through the membranous septum. This anatomical defect also can be figured out with a pericardium patch [15].…”

Section: Surgery Treatmentmentioning

confidence: 99%

Right-Sided Infective Endocarditis

Muñoz¹,

Vargas²

2019

Infective Endocarditis

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Infective endocarditis (IE) at the right side represents the 5-10% of IE cases. It is more frequent in people with intravenous drug addiction (IVDA); however, there is another population susceptible to this infection; hemodialytic patients, intracardiac devices, and congenital heart diseases are included inside this group. Right-sided infective endocarditis (RSIE) has lower mortality than the left-sided infective endocarditis (LSIE). Common symptoms secondary to right-sided endocarditis are the respiratory symptoms characterized by a cough, hemoptysis, persistent fever, dyspnea, and chest pain. Echocardiography and blood cultures are the first tools to perform the diagnosis. The tricuspid valve is the main anatomical structure affected. Medical treatment with antibiotic therapy resolves the infection majority of the time; the surgical treatment is indicated in some cases, such as right-heart failure due to severe tricuspid valve regurgitation; inability to eliminate bacteremia or organism; resistance to culture-directed antibiotic treatment, within 7 days; and tricuspid valve vegetations >20 mm. RSIE implies a better prognosis than LSIE. Concomitant left-sided IE carries a worse prognosis than right-sided infection alone, due predominantly to its greater likelihood for invasion and abscess formation.

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Acquired ventricular septal defect due to infective endocarditis

Cited by 9 publications

References 7 publications

Acquired Ventricular Septal Defect in Panton-Valentine Leukocidin-Positive Staphylococcus aureus Infective Endocarditis

Acquired Ventricular Septal Defect in Panton-Valentine Leukocidin-Positive Staphylococcus aureus Infective Endocarditis

Clinical Profile of Pediatric Patients with Acyanotic Congenital Heart Disease in Dr. Soetomo General Hospital Surabaya

Right-Sided Infective Endocarditis

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