Acquisition of
            <i>Helicobacter pylori</i>
            Infection in Rhesus Macaques Is Most Consistent with Oral-Oral Transmission

Solnick, Jay V.; Fong, Julie; Hansen, Lori M.; Chang, K. J.; Canfield, Don R.; Parsonnet, Julie

doi:10.1128/jcm.01482-06

Cited by 24 publications

(13 citation statements)

References 21 publications

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“…The apparent competition between H. pylori and H. suis in the antrum is striking, particularly since each species tends to occupy a distinct compartment of the stomach. Experimentally-inoculated H. pylori is found predominately in the antrum [47], while non- pylori-Helicobacter spp. are routinely observed within or adjacent to the parietal cells of the corpus [48], with a reported tropism for the fundus of the stomach [19].…”

Section: Resultsmentioning

confidence: 99%

The Impact of Helicobacter pylori Infection on the Gastric Microbiota of the Rhesus Macaque

et al. 2013

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Helicobacter pylori colonization is highly prevalent among humans and causes significant gastric disease in a subset of those infected. When present, this bacterium dominates the gastric microbiota of humans and induces antimicrobial responses in the host. Since the microbial context of H. pylori colonization influences the disease outcome in a mouse model, we sought to assess the impact of H. pylori challenge upon the pre-existing gastric microbial community members in the rhesus macaque model. Deep sequencing of the bacterial 16S rRNA gene identified a community profile of 221 phylotypes that was distinct from that of the rhesus macaque distal gut and mouth, although there were taxa in common. High proportions of both H. pylori and H. suis were observed in the post-challenge libraries, but at a given time, only one Helicobacter species was dominant. However, the relative abundance of non-Helicobacter taxa was not significantly different before and after challenge with H. pylori. These results suggest that while different gastric species may show competitive exclusion in the gastric niche, the rhesus gastric microbial community is largely stable despite immune and physiological changes due to H. pylori infection.

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Section: Resultsmentioning

confidence: 99%

The Impact of Helicobacter pylori Infection on the Gastric Microbiota of the Rhesus Macaque

et al. 2013

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“…Socially housed rhesus monkeys rapidly acquire H. pylori infection. Newborns from infected dams are more commonly infected than those from uninfected dams, particularly during the peripartum period, suggesting that close contact during this time facilitates oral-oral transmission (213,214). Once acquired, infection is associated with chronic gastritis that resembles that seen in humans.…”

Section: Gastric Helicobacters Associated With Nonhuman Primatesmentioning

confidence: 99%

“…In human patients presenting severe pathology and clinical symptoms associated with the presence of non-H. pylori helicobacters, treatment is indicated, although the efficacy of such 214 HAESEBROUCK ET AL. CLIN.…”

Section: Gastric Disease In Humans Infected With Non-h Pylori Helicomentioning

confidence: 99%

Gastric Helicobacters in Domestic Animals and Nonhuman Primates and Their Significance for Human Health

et al. 2009

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SUMMARY Helicobacters other than Helicobacter pylori have been associated with gastritis, gastric ulcers, and gastric mucosa-associated lymphoid tissue lymphoma in humans. These very fastidious microorganisms with a typical large spiral-shaped morphology were provisionally designated “H. heilmannii,” but in fact they comprise at least five different Helicobacter species, all of which are known to colonize the gastric mucosa of animals. H. suis, which has been isolated from the stomachs of pigs, is the most prevalent gastric non-H. pylori Helicobacter species in humans. Other gastric non-H. pylori helicobacters colonizing the human stomach are H. felis, H. salomonis, H. bizzozeronii, and the still-uncultivable “Candidatus Helicobacter heilmannii.” These microorganisms are often detected in the stomachs of dogs and cats. “Candidatus Helicobacter bovis” is highly prevalent in the abomasums of cattle but has only occasionally been detected in the stomachs of humans. There are clear indications that gastric non-H. pylori Helicobacter infections in humans originate from animals, and it is likely that transmission to humans occurs through direct contact. Little is known about the virulence factors of these microorganisms. The recent successes with in vitro isolation of non-H. pylori helicobacters from domestic animals open new perspectives for studying these microorganisms and their interactions with the host.

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“…Fecal-oral transmission may be possible under conditions in which H pylori survive transit through the lower gastrointestinal tract, which is uncommon in healthy people. [17][18][19][20] An experimental study in humans confirmed that H pylori is not typically culturable in normal human feces, but, when diarrhea is induced in naturally infected volunteers, up to 20% of stool samples contain culturable H pylori. 19 The same study showed that when emesis is induced in infected volunteers, all samples of vomitus contain culturable H pylori, often in high numbers.…”

Section: Bacterial Factors Transmission and Entrymentioning

confidence: 99%

Host-Bacterial Interactions in Helicobacter pylori Infection

2008

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Acquisition of Helicobacter pylori Infection in Rhesus Macaques Is Most Consistent with Oral-Oral Transmission

Cited by 24 publications

References 21 publications

The Impact of Helicobacter pylori Infection on the Gastric Microbiota of the Rhesus Macaque

The Impact of Helicobacter pylori Infection on the Gastric Microbiota of the Rhesus Macaque

Gastric Helicobacters in Domestic Animals and Nonhuman Primates and Their Significance for Human Health

Host-Bacterial Interactions in Helicobacter pylori Infection

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