Acquisition of serum antibodies against filamentous hemagglutinin and pertactin unrelated to Bordetella pertussis infection

Carlsson, Rose-Marie; Claesson, Bo A.; Lagergård, Teresa; Trollfors, Birger

doi:10.1111/j.1469-0691.1999.tb00520.x

Cited by 7 publications

(6 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…OPA, C3b deposition, and IgG binding to live bacteria cannot be used as criteria for diagnosing pertussis because of cross-reactivity with B. parapertussis or other microorganisms (6,12,13,39). Accordingly, several serum samples with rather low levels of IgG antibodies to PT were highly positive in these assays.…”

Section: Discussionmentioning

confidence: 99%

“…(21,24). Cross-reacting antibodies have been ascribed to non-Bordetella species like Chlamydia pneumoniae or Mycoplasma pneumoniae (39), and nonencapsulated Haemophilus influenzae expresses antigens that induce antibodies cross-reacting with FHA (3,6). By measuring antibodies against live B. pertussis, we may quantify all antibody specificities binding to the surface of intact bacteria.…”

Section: Discussionmentioning

confidence: 99%

“…pertussis harbors species-specific antigens but also crossreacting antigens shared with other Bordetella species and possibly other bacterial species (6,12,13,39). Conceivably, several of these shared antigens may give rise to antibodies important for protection.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Opsonophagocytic Activity and Other Serological Indications ofBordetella pertussisInfection in Military Recruits in Norway

Aase

Herstad

Merino

et al. 2007

Clin Vaccine Immunol

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Opsonophagocytic Activity and Other Serological Indications ofBordetella pertussisInfection in Military Recruits in Norway

Aase

Herstad

Merino

et al. 2007

Clin Vaccine Immunol

View full text Add to dashboard Cite

show abstract

“…In follow-up sera from unvaccinated children, obtained at ages 2, 4, 6, 13, and 30 months, Ն2-fold increases of IgGs to B. pertussis FHA and Prn occurred between the ages of 13 and 30 months in 20/44 and 10/44 children, respectively, while none had detectable IgG-Ptx antibodies at those time points. Furthermore, in children from whom sera had been obtained at ages 13 months and 6 years, Ն2-fold increases of IgGs against B. pertussis FHA and Prn in the absence of detectable IgG-Ptx occurred in 11/14 and 8/14 children, respectively (219). In serial sera from 71 children, obtained before, during, and after vaccination with a monocomponent Ptx-containing ACV vaccine, maternally derived IgG-Prn and IgG-FHA declined in the first 3 months of life.…”

Section: Serodiagnosis Of Pertussismentioning

confidence: 99%

Laboratory Diagnosis of Pertussis

2015

View full text Add to dashboard Cite

SUMMARYThe introduction of vaccination in the 1950s significantly reduced the morbidity and mortality of pertussis. However, since the 1990s, a resurgence of pertussis has been observed in vaccinated populations, and a number of causes have been proposed for this phenomenon, including improved diagnostics, increased awareness, waning immunity, and pathogen adaptation. The resurgence of pertussis highlights the importance of standardized, sensitive, and specific laboratory diagnoses, the lack of which is responsible for the large differences in pertussis notifications between countries. Accurate laboratory diagnosis is also important for distinguishing between the several etiologic agents of pertussis-like diseases, which involve both viruses and bacteria. If pertussis is diagnosed in a timely manner, antibiotic treatment of the patient can mitigate the symptoms and prevent transmission. During an outbreak, timely diagnosis of pertussis allows prophylactic treatment of infants too young to be (fully) vaccinated, for whom pertussis is a severe, sometimes fatal disease. Finally, reliable diagnosis of pertussis is required to reveal trends in the (age-specific) disease incidence, which may point to changes in vaccine efficacy, waning immunity, and the emergence of vaccine-adapted strains. Here we review current approaches to the diagnosis of pertussis and discuss their limitations and strengths. In particular, we emphasize that the optimal diagnostic procedure depends on the stage of the disease, the age of the patient, and the vaccination status of the patient.

show abstract

“…22,33,34,38 -41 Antibodies to FHA and pertactin, in contrast, are found in increasingly higher incidence as children grow older and their presence is often unrelated to a history of pertussis. 41,42 The stimulus for antibodies to these 2 proteins may be cross-reactive proteins on bacteria other than Bordetellae. 43 …”

Section: Age-related Acquisition Of Serum Igg Antibodies To Pt Fha mentioning

confidence: 99%

Immunologic and Epidemiologic Experience of Vaccination With a Monocomponent Pertussis Toxoid Vaccine

et al. 2001

Self Cite

View full text Add to dashboard Cite

ABSTRACT. Pertussis re-emerged in Sweden with a cumulative incidence of about 60% during the first 10 years of life, when the locally produced cellular vaccine lost its efficacy around 1970 and general vaccination was discontinued in 1979. The epidemiology, clinical features, and immunology of pertussis and a monocomponent pertussis toxoid vaccine were studied in Gö teborg, Sweden.After phase 1 and 2 studies, a randomized, doubleblind, placebo-controlled trial of pertussis toxoid (PTox), compounded with diphtheria and tetanus toxoids, was administered to 3450 children according to the Swedish schedule at 3, 5, and 12 months of age. After a mean follow-up of 18 months, the efficacy was 71% overall and 75% in household contacts, respectively. A statistically significant correlation was found between the level of PTox-induced antibodies and protection against pertussis. As observed with cellular and with multicomponent acellular vaccines, PTox reduced the severity of disease and the percent of children with positive cultures. Furthermore, vaccination reduced the transmission of Bordetella pertussis to household contacts in the vaccinees compared with the controls who received only diphtheria and tetanus toxoids. Patients with culture-verified Bordetella parapertussis infection reacted with antibodies to pertactin and to filamentous hemagglutinin but not to pertussis toxin, and some subsequently developed pertussis. The antibody responses of patients with pertussis to the surface polysaccharides of B pertussis and to B parapertussis were cross-reactive serologically. Serosurveys showed that only antibodies to pertussis toxin were related to the occurrence of pertussis in the general population: antibodies to filamentous hemagglutinin and pertactin were probably stimulated by antigens of other bacteria as well as Bordetellae.Mass vaccination of Gö teborg children born in the 1990s was started in 1995. In February 1999, about 55% had been vaccinated and both B pertussis and pertussis decreased significantly in individuals of all ages (herd immunity). Similar to diphtheria, PTox-induced immunity to pertussis occurs both on an individual and community basis.The apparent greater efficacy of multicomponent acellular pertussis vaccines compared with monocomponent PTox was proposed to be an artifact created when the diagnosis of pertussis was made by the serologic criteria of the World Health Organization only. Our conclusion is that PTox is both an essential and alone sufficient antigen in acellular pertussis vaccines. Pediatrics 2001; 108(6). URL: http://www.pediatrics.org/cgi/content/full/ 108/6/e115; pertussis, pertussis toxoid, vaccine.

show abstract

Acquisition of serum antibodies against filamentous hemagglutinin and pertactin unrelated to Bordetella pertussis infection

Cited by 7 publications

References 17 publications

Opsonophagocytic Activity and Other Serological Indications ofBordetella pertussisInfection in Military Recruits in Norway

Opsonophagocytic Activity and Other Serological Indications ofBordetella pertussisInfection in Military Recruits in Norway

Laboratory Diagnosis of Pertussis

Immunologic and Epidemiologic Experience of Vaccination With a Monocomponent Pertussis Toxoid Vaccine

Contact Info

Product

Resources

About