Acr emonium Species: A Review of the Etiological Agents of Emerging Hyalohyphomycosis

Das, Shukla; Saha, Rumpa; Dar, Sajad Ahmad; Ramachandran, V G

doi:10.1007/s11046-010-9334-1

Cited by 59 publications

(55 citation statements)

References 72 publications

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“…The last 2 decades have witnessed a steady increase in the spectrum of hyaline fungi incriminated as opportunistic pathogens in immunocompromised patients (5,14,28). Many soil saprobes and plant pathogens with no obvious pathogenic potential have now emerged as etiologic agents under a variety of clinical conditions, thus posing new diagnostic and therapeutic challenges (38).…”

Section: Case Reportmentioning

confidence: 99%

“…Although Aspergillus and Fusarium are two major pathogenic filamentous genera, the role of Acremonium spp. is also being increasingly recognized in both localized and systemic infections (5,7,28). In immunocompetent individuals, keratitis, endophthalmitis, mycetoma, onychomycosis, or cutaneous infections are the most familiar forms of localized infections (5, 38).…”

Section: Case Reportmentioning

confidence: 99%

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Acremonium kiliense: Reappraisal of Its Clinical Significance

et al. 2011

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A case of Acremonium kiliense peritonitis is described. Diagnosis was established by repeated isolation of the fungus from peritoneal dialysate and by its identification on the basis of morphological characteristics and sequencing of internal transcribed spacer (ITS) regions of ribosomal DNA (rDNA). This report and available literature suggest that A. kiliense may have a greater clinical significance than hitherto recognized. CASE REPORTA 75-year-old Jordanian man with a long history of diabetes mellitus and hypertension developed end-stage kidney disease requiring continuous ambulatory peritoneal dialysis (CAPD). His course of CAPD was largely uneventful except for a single episode of bacterial peritonitis, for which he was hospitalized and treated with parenteral antibiotics, with an excellent response. In January 2010, he became febrile, with clinical evidence of peritonitis, and was admitted to the hospital. The peritoneal fluid was turbid, with a white blood cell (WBC) count of 2.1 ϫ 10 9 /liter. On initial microscopic examination, the presence of fungal elements in the peritoneal dialysate was missed. The peritoneal fluid sample was inoculated into aerobic Bactec blood culture bottles, which yielded a growth after 59 h of incubation. The Gram-stained smear from blood culture bottles showed branched hyphal elements. On Sabouraud dextrose agar (SDA; Oxoid Ltd., Basingstoke, England), the specimen yielded slimy colonies with a pinkish appearance ( Fig. 1). Microscopic examination of the primary culture (isolate Kw441-2010) showed hyaline hyphae, with scanty sporulation. A provisional identification of Acremonium/Fusarium species was made, and the growth was subcultured on Sabouraud dextrose agar and oatmeal agar (OMA; oatmeal [30 g], agar [20 g], distilled water [1 liter]) for further identification and antifungal susceptibility testing. Subsequent cultures of the peritoneal fluid yielded the same fungus on three occasions. A serum sample was obtained for the detection of galactomannan (Platelia Aspergillus enzyme immunoassay [EIA] kit; BioRad, Marnes-la-Coquette, France) and (1-3)-␤-D-glucan (Fungitell; Associates of Cape Cod); the latter test was positive (253 pg/ml). An Etest performed on RPMI 1640 medium supplemented with 2% glucose revealed that the isolate was resistant to amphotericin B and caspofungin but susceptible to voriconazole and posaconazole, with MIC values of Ͼ32 g/ml, Ͼ32 g/ml, 0.064 g/ml, and 0.75 g/ml, respectively. The patient was started on voriconazole, with a loading dose of 400 mg, followed by a maintenance dose of 200 mg, given every 12 h via the oral route. Although the patient showed clinical improvement after 2 weeks of voriconazole therapy, the peritoneal dialysate remained turbid (WBC counts, 2.0 ϫ 10 9 / liter). Abdominal ultrasound examination did not reveal any evidence of intraperitoneal adhesions or organ invasion. Since the response to treatment was not adequate, the Tenckhoff catheter was removed and the patient was temporarily switched to hemodialysis. After 1 week of a...

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Section: Case Reportmentioning

confidence: 99%

Section: Case Reportmentioning

confidence: 99%

Acremonium kiliense: Reappraisal of Its Clinical Significance

et al. 2011

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“…Das et al, reported a total of 17 cases between 1971 and 2010 of worldwide clinical ocular infections caused by different species of acremonium, which described symptoms including keratitis and endophthalmitis in these patients. 3 Alfonso et al reported four cases of acremonium fungal keratitis associated with laser-assisted in situ keratomileusis (LASIK) that were performed by different surgeons during the same time period in the same operating room. 4 Aside from these instances, until recently, there had been no other reported case series of acremonium fungal keratitis.…”

Section: Introductionmentioning

confidence: 99%

A case report of pregnant female with right eye acremonium keratitis

et al. 2017

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Study report a case of a 22-years-old female with history of vegetative trauma in right eye with 7th running months of amenorrhoea (RMOA). She came after 10 days of trauma, with chief complaint of pain, watering and diminution of vision in right eye. Her visual acuity was PLPR4 in affected eye and 6/9 in other. Central corneal ulcer with abscess and hypopyon was noted with inability to see fundal glow. To study response of fungal keratitis to voriconazole and natamycin eye drop. Corneal tissue obtained by a corneal scrape was plated on Sabouraud’s agar, KOH mount, gram and giemsa staining was performed. SDA shows a filamentous colony of fungus is grown upon aerobic incubation at 37◦C for 5-7 days. Patient was treated with combination therapy of voriconazole and natamycin eye drop. Patient responded well to combination therapy of voriconazole and natamycin eye drop. Patient developed corneal healing with little amount of fibrosis. We lost patient on follow up after that. Patient responded well to combination therapy of voriconazole and natamycin eye drop. The most common risk factors for acremonium fungal keratitis is ocular trauma, and acremonium fungal keratitis might be treated better with natamycin and voriconazole than other alternatives. our results are clinically significant and may provide some useful information on the diagnosis and management of acremonium fungal keratitis.

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“…They are associated with a wide spectrum of clinical diseases, including both localized and disseminated infections in immunocompetent and immunocompromised hosts (4,6,12,14,15). Acremonium species are also pathogenic to other fungi (mycopathogenic) and have been used as biological controls for fungal plant pathogens (3,13).…”

mentioning

confidence: 99%

“…Unlike Acremonium, however, this species has not been associated with disease in humans in spite of its abundance in the natural environment (10). Acremonium and Lecanicillium share many morphological features, including hyaline colony, cottony texture, and similar arrangement of conidia and conidiophores, that make morphological distinction between the two fungal taxa challenging (4,7,9). We investigated a cluster of Acremonium and Lecanicillium isolates recovered from tissues removed from patients during orthopedic surgery at hospital A.…”

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confidence: 99%

Pseudo-Outbreak of Lecanicillium and Acremonium Species in Orthopedic Surgery Patients

et al. 2012

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Acremonium species cause a variety of human infections, while Lecanicillium species have not been reported as human pathogens. We describe a pseudo-outbreak involving both organisms, highlighting the role and limitations of molecular methods in the characterization of rare fungal isolates. Repeated isolation of these fungi from patient tissue samples raises concerns about exogenous contamination in the hospital environment.

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Acr emonium Species: A Review of the Etiological Agents of Emerging Hyalohyphomycosis

Cited by 59 publications

References 72 publications

Acremonium kiliense: Reappraisal of Its Clinical Significance

Acremonium kiliense: Reappraisal of Its Clinical Significance

A case report of pregnant female with right eye acremonium keratitis

Pseudo-Outbreak of Lecanicillium and Acremonium Species in Orthopedic Surgery Patients

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