Acral melanocytic lesions in the United States: Prevalence, awareness, and dermoscopic patterns in skin-of-color and non-Hispanic white patients

Madankumar, Reshmi; Gumaste, Priyanka; Martires, Kathryn J.; Schaffer, Panta Rouhani; Choudhary, Sonal; Falto‐Aizpurua, Leyre; Arora, Harleen; Kallis, Penelope; Patel, Shubham; Damanpour, Shadi; Sánchez, Margarita Dorantes; Yin, Natalie; Chan, Aegean; Sanchez, Miguel; Polsky, David; Kanavy, Holly; Grichnik, James M.; Stein, Jennifer A.

doi:10.1016/j.jaad.2015.11.035

Cited by 43 publications

(43 citation statements)

References 31 publications

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“…We found a prevalence of 6.8%, similar to that reported in other studies, ranging from 6% to 8%. 2 , 22 A recent study published by Madankumar R 30 , with cases from a highly heterogeneous population in New York and Miami, found a prevalence of 36%, far higher than previously reported. This may have been due to the inclusion of patients with skin phototypes V and VI, who are more prone to presenting pigmented lesions on the volar skin.…”

Section: Discussionmentioning

confidence: 88%

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Dermoscopic features of acral melanocytic nevi in a case series from Mexico

González-Ramírez

Guerra-Segovia

Garza‐Rodríguez

et al. 2018

An. Bras. Dermatol.

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BackgroundPigmented lesions on acral sites are common; clinical differentiation of nevi and early melanoma can be challenging. In these cases, dermoscopy can provide a more accurate diagnosis. Most dermoscopic patterns on acral skin have been described in Asian and European populations, while there are few studies in Latin American populations.ObjectivesTo determine the frequency of pigmented lesions in volar skin and their dermoscopic patterns in a Mexican population. Methods: An observational, descriptive, cross-sectional study was performed in Hispanic patients with the presence of at least one pigmented lesion on acral skin. Clinical and dermoscopic images were obtained. These were subsequently evaluated independently by two dermatologists trained and experienced in dermoscopy.ResultsA total of 582 pigmented lesions on volar skin were diagnosed in 321 patients. Overall, prevalence of acral pigmented lesions on volar skin was 6.8%. For both observers, parallel furrows were the most frequent pattern described, but for observer 2, a lattice-like pattern was prevalent on the toes and a homogeneous pattern on the sides of the feet. There was lower inter-observer agreement, with a kappa index of 0.144.Study limitationsThe lesions were not biopsied, so clinical-histological correlation could not be performed. The study did not correlate dermoscopic patterns with age.Conclusions.As previously reported by other authors, parallel furrows were the most frequently found dermoscopic pattern on palmoplantar skin.

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Section: Discussionmentioning

confidence: 88%

“…This may have been due to the inclusion of patients with skin phototypes V and VI, who are more prone to presenting pigmented lesions on the volar skin. 30 …”

Section: Discussionmentioning

confidence: 99%

Dermoscopic features of acral melanocytic nevi in a case series from Mexico

González-Ramírez

Guerra-Segovia

Garza‐Rodríguez

et al. 2018

An. Bras. Dermatol.

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“…It often occurs in skin and mucosa, and can also occur in the eyes, nasal cavity, pharynx and throat, anal and rectum, and the central nervous system 23,24 . Cutaneous malignant melanoma (CMM) is the most malignant tumor in primary skin tumors and accounts for about 80% of all skin cancer deaths 25 . MM characterized by rapid occurrence, prone to distant metastasis and poor prognosis 26 .…”

Section: Discussionmentioning

confidence: 99%

Total saponins from Rubus parvifolius L. inhibits cell proliferation, migration and invasion of malignant melanoma in vitro and in vivo

Cao

Zhao

et al. 2021

Bioscience Reports

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Background: Total saponins from Rubus parvifolius L. (TSRP) is the main bioactive fractions responsible for the antitumor activities. The work was aimed to evaluate the anti-tumor effect of TSRP in malignant melanoma in vitro and in vivo. Methods and Results: Anti melanoma cell proliferation, invasion and migration effect of TSRP were detected in human malignant melanoma A375 cells under the indicated time and dosages. In vivo anti-tumor effect of TSRP was measured in A375 xenograft immunodeficient nude mice. Sixty A375 xenografts were randomly divided into five groups: Vehicle, cyclophosphamide (CTX, 20 mg/kg), TSRP (25 mg/kg), TSRP (50 mg/kg) and TSRP (100 mg/kg) groups for 14 days’ treatment. In addition, the melanoma cell metastasis in lung in vivo of TSRP was detected in A375 tail vein injection mice, and the histopathalogical analysis of the metastasis lung was detected by H & E stating. TSRP was significantly inhibited the cell proliferation, invasion and migration of A375 in vitro at the indicated time and dosages. TSRP treatment was effectively blocked the tumor growth in immunodeficient nude mice. In addition, TSRP was also significantly inhibited the melanoma metastasis of lung. Conclusion: This study indicated that the TSRP has a remarkable anti malignant melanoma effect, which mainly through the inhibition of the cell invasion,migration and tumor metastasis.

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“…Table shows the incidence of AM among diagnoses of all cutaneous MM in different ethnic populations. Patients with darker skin phototypes are more likely to have acral melanocytic lesions than non‐Hispanic white patients, and often are unaware of the presence of these lesions . AM can also be missed in fair‐skinned individuals prone to amelanotic lesions.…”

Section: Introduction and Epidemiologymentioning

confidence: 99%

Acral melanoma foot lesions. Part 1: epidemiology, aetiology, and molecular pathology

2017

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Acral melanoma (AM) is a rare subtype of cutaneous malignant melanoma (MM) found on acral skin, primarily on the soles of the feet. Although rare, it is the most common subtype of MM found in patients of African or East Asian ethnicity and has a poor prognosis, often because of the more advanced stage of presentation at diagnosis. The pathogenesis of AM is unclear, but genetic alterations, including mutations in BRAF, NRAS, and KIT have been implicated. Early diagnosis of AM is important for a better prognosis, but its identification is often challenging, leading to easy misdiagnosis. In the first of this two-part review, we review the history, epidemiology, aetiology and molecular pathology of AM; in part 2 we will review diagnosis and management.

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Acral melanocytic lesions in the United States: Prevalence, awareness, and dermoscopic patterns in skin-of-color and non-Hispanic white patients

Cited by 43 publications

References 31 publications

Dermoscopic features of acral melanocytic nevi in a case series from Mexico

Dermoscopic features of acral melanocytic nevi in a case series from Mexico

Total saponins from Rubus parvifolius L. inhibits cell proliferation, migration and invasion of malignant melanoma in vitro and in vivo

Acral melanoma foot lesions. Part 1: epidemiology, aetiology, and molecular pathology

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