Acral persistent papular mucinosis in two sisters

Menni, S.; Cavicchini, S.; Brezzi, A.; Gianotti, Raffaele; Caputo, Ruggero

doi:10.1111/j.1365-2230.1995.tb01366.x

Cited by 18 publications

(14 citation statements)

References 12 publications

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“…A recent review of all APPM cases described to date showed that, based on the above classification, the clinical and histological criteria of only 20 cases allow them to be convincingly labelled as APPM, underlining the rarity of this condition 5 . Interestingly, however, this condition was been noted in two sisters 6 . The lesions of APPM are usually asymptomatic, and no treatment is known to be effective.…”

Section: Discussionmentioning

confidence: 99%

Multiple asymptomatic papules on the legs

2007

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Section: Discussionmentioning

confidence: 99%

Multiple asymptomatic papules on the legs

2007

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“…Since then, several cases of this entity have been reported. 17 , 19–21 Acral persistent papular mucinosis is characterized according to Rongioletti and Rebora 18 by 2–5 mm papules, symmetrically arranged on the dorsal aspects of the hands and wrists with occasional extension to the forearms, knees, and elbows. This entity has a chronic course, without paraproteinemia or other systemic associations.…”

Section: Discussionmentioning

confidence: 99%

Atypical acral persistent papular mucinosis

Abalde¹,

Ginarte²,

Fernández‐Redondo³

et al. 1999

Int J Dermatology

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A 70‐year‐old woman presented with a 10‐year history of cutaneous lesions on her calves that worsened with solar exposure. Her past medical history was irrelevant. Physical examination revealed 10–15 erythematous, firm nodules with a diameter of 2–5 mm, which were slightly painful on palpation. The lesions were located on both calves, although some elements extended to the posterior side of the thighs ( Fig. 1). General physical examination did not show any abnormalities. A biopsy specimen from one of the elements showed a normal epidermis and, in the upper dermis, a slight inflammatory infiltrate of mononuclear cells, with the presence of splits between collagen fibers ( Fig. 2). Alcian blue stain at pH 2.5 revealed the existence of mucinous material in these spaces ( Fig. 3). An electron microscopic study did not show any abnormalities. 1 Clinical appearance of the lesions 2 Histopathologic picture (hematoxylin and eosin, ×40) 3 Alcian blue stain showing the presence of mucin in the dermis (Alcian blue, ×100) The patient was diagnosed as having papular mucinosis. The following studies were normal or negative: complete cell blood count, serum biochemistry, serum protein electrophoresis, serum immunoelectrophoresis, serologic test for human immunodeficiency virus (HIV), hepatitis B and C viruses, and syphilis, antinuclear antibodies, and thyroid hormone levels. No treatment was carried out.

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“…It is rare in younger patients with only three patients who were less than 20 years of age at the onset of their lesions. [17,19] In our case the age of onset was lesion was 54 year. Lesions are generally asymptomatic, only three had pruriticlesions.…”

Section: Discussionmentioning

confidence: 99%

“…[2,[14][15][16] They mainly involve the back of the hands and wrists, the distal aspects of the forearms, and rarely the antecubital fossae. All cases described till date are sporadic except for a pair of sisters [17] and another patient's father having suspicious lesions. [18] According to review done by Di-Quing Luo et al APPM is more common in females, though we are reporting it in male adult.…”

Section: Discussionmentioning

confidence: 99%