Acremonium infection in a neutropenic patient

Brown, Nicholas; Blundell, E.; Chown, Sally; Warnock, David W.; Hill, Judith A.; Slade, Robert

doi:10.1016/0163-4453(92)93585-e

Cited by 21 publications

(17 citation statements)

References 5 publications

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“…curvatum W. Gams which are close to Phialemonium on morphological grounds have been associated with opportunistic infections, e.g. in relation to exit sites of intraperitoneal or intravascular catheters [6][7][8][9]. It must be emphasized that our patient did not have a permanent intravascular catheter at any time.…”

Section: Discussionmentioning

confidence: 96%

Late bioprosthetic valve endocarditis caused byPhialemoniumaff.curvatumandStreptococcus sanguis: a case report

Schønheyder

Jensen²,

Gams³

et al. 1996

Med Mycol

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Dual fungal and Streptococcus sanguis endocarditis is reported in a 63-year-old woman 7 months after placement of a porcine aortic valve prosthesis. Both microorganisms were isolated by blood cultures, and the patient succumbed after a full course of antibacterial chemotherapy without having received antifungal chemotherapy. The best possible designation of the fungus was Phialemonium aft. curvatum W. Gams & W. B. Cooke, as represented by CBS 331.93. At autopsy hyphae were revealed in the porcine valve tissue by conventional staining. A hyperimmune rabbit antiserum raised towards strain CBS 331.93 and extensively absorbed with heterologous fungal antigens reacted strongly with hyphae in the valve tissue by indirect immunofluorescence technique. We consider it most likely that the Phialemonium infection evolved insidiously from the time of open heart surgery and led to a haematogenous streptococcal infection of a more fulminant course.

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Section: Discussionmentioning

confidence: 96%

Late bioprosthetic valve endocarditis caused byPhialemoniumaff.curvatumandStreptococcus sanguis: a case report

Schønheyder

Jensen²,

Gams³

et al. 1996

Med Mycol

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“…Acremonium fungemia associated with CVC has been reported in neutropenic patients and in nonneutropenic patients receiving long-term total parenteral nutrition [5–8]. …”

Section: Discussionmentioning

confidence: 99%

Catheter-RelatedAcremonium kilienseFungemia in a Patient with Ulcerative Colitis under Treatment with Infliximab

Díaz-Couselo

Zylberman

2011

Case Reports in Infectious Diseases

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Acremonium spp. are filamentous, cosmopolitan fungi commonly isolated from plant debris and soil. They are infrequent pathogens in humans. Acremonium fungemia has been reported in neutropenic patients associated with central venous catheters and in nonneutropenic patients receiving long-term total parenteral nutrition. TNF-α blockade is associated with fungal infections, but no Acremonium spp. infection had been reported up to the present. In this paper, we present a patient with ulcerative colitis who developed Acremonium kiliense fungemia associated with infliximab therapy while receiving total parenteral nutrition. The patient was successfully treated with voriconazole. Acremonium sp. infection must be suspected as another cause of fungal infection in patients under treatment with infliximab.

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“…Finally, the propensity of Phialemonium species to produce disease in abnormal or unexpected sites and the nosocomial nature of these infections are notable. The association with catheters and prosthetic valve infections suggests that Phialemonium species are similar to the closely related Acremonium species, which are a common cause of catheter infections (1,6,9,12,15,17), in the ability to attach to plastic or foreign materials.…”

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confidence: 99%

Fatal Endocarditis in a Neonate Caused by the Dematiaceous FungusPhialemonium obovatum: Case Report and Review of the Literature

2002

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Phialemonium species are grouped by most authorities among the dematiaceous fungi. Like several other darkly pigmented fungi, they appear to be an emerging cause of human disease, especially in the immunocompromised host. As numbers of immunocompromised patients increase, the trend of unusual fungi emerging as new pathogens is set to continue. Previous experience suggests that reports of rare fungal infections among selected patients often heralds the emergence of infection in a wider population of patients. We report a case of fatal endocarditis caused by Phialemonium obovatum in a premature neonate. To our knowledge this is the first documented case of native valve endocarditis due to this species, and we review the literature on invasive disease caused by the species. Unfamiliar fungal isolates are frequently misidentified or mistaken for environmental contaminants, and because of their relative rarity, data upon which to base antifungal treatment are limited. Thus, the diagnosis and treatment of unusual fungal pathogens present a significant challenge to clinicians and microbiologists alike. Early referral of such isolates to a specialist reference laboratory is advisable.

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Acremonium infection in a neutropenic patient

Cited by 21 publications

References 5 publications

Late bioprosthetic valve endocarditis caused byPhialemoniumaff.curvatumandStreptococcus sanguis: a case report

Late bioprosthetic valve endocarditis caused byPhialemoniumaff.curvatumandStreptococcus sanguis: a case report

Catheter-RelatedAcremonium kilienseFungemia in a Patient with Ulcerative Colitis under Treatment with Infliximab

Fatal Endocarditis in a Neonate Caused by the Dematiaceous FungusPhialemonium obovatum: Case Report and Review of the Literature

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