Acrocyanosis as a presenting symptom of hodgkin lymphoma

Solak, Yalcin; Aksoy, Sercan; Kılıçkap, Saadettin; Çeli̇k, İsmai̇l

doi:10.1002/ajh.20479

Cited by 11 publications

(8 citation statements)

References 5 publications

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“…32,153 Multiple reports describe an association between acrocyanosis and cold agglutinins, cryoglubulins, or cryofibrinogen. 28,33,154–156 Almost a third of all patients with positive antiphospholipid antibodies have acrocyanosis.…”

Section: Secondary Acrocyanosismentioning

confidence: 99%

“…Lymphoproliferative [31][32][33][34] Myeloproliferative disorders [35][36][37] Cold agglutinins 28,38,39 Ethylmalonic aciduria [59][60][61] Cytochrome C oxidase deficiency 62,63 Mitochondrial disease (oxidative phosphorylation disorders) 64 Spondyloenchondrodysplasia 65 Palmoplantar keratoderma syndrome 66 Fucosidosis 67 Down's syndrome 68 Prader-Willi syndrome 69 Sneddon's syndrome 70,71 Aicardi-Goutières syndrome 72,73 Marfan's disease Riley-Day syndrome (familial dysautonomia) 74 Ehlers-Danlos syndrome 75,76 Psychiatric:…”

Section: Secondary Acrocyanosismentioning

confidence: 99%

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Acrocyanosis: The Flying Dutchman

2011

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Acrocyanosis is symmetric, painless, discoloration of different shades of blue in the distal parts of the body that is marked by symmetry, relative persistence of the skin color changes with aggravation by cold exposure, and frequent association with local hyperhidrosis of hands and feet. Described over a century ago and despite seeming familiarity, it remains a poorly understood condition that shares much in clinical presentation with other conditions characterized by skin color changes in the distal parts of the body. The diagnosis remains mostly clinical, and pathological mechanisms vary suggesting that acrocyanosis may not be a single entity. We performed an extensive literature review to summarize existing knowledge about the demographics, pathology, diagnosis, and treatment of this condition.

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Section: Secondary Acrocyanosismentioning

confidence: 99%

Section: Secondary Acrocyanosismentioning

confidence: 99%

Acrocyanosis: The Flying Dutchman

2011

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“…Digital ischemia as a paraneoplastic syndrome of Hodgkin's disease is an unusual finding [ 4 , 5 ]. There are very little data in the literature that was reviewed, mostly case reports, as shown in Table 1 [ 5 – 7 ]. In fact, pathogenic mechanism of paraneoplastic acral vascular syndromes is poorly understood and likely multifactorial.…”

Section: Discussionmentioning

confidence: 99%

Digital Ischemia as an Unusual Manifestation of Hodgkin’s Lymphoma

Villano

Peixoto

Riva

et al. 2018

Case Reports in Hematology

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Digital ischemia is associated with atherosclerotic, thromboembolic, or connective tissue diseases. Less often, it can be related to malignancy. Paraneoplastic vascular acrosyndromes (Raynaud's syndrome, acrocianosis, and acronecrosis) are associated with adenocarcinoma and less frequently with hematological malignancies. We report the case of a 45-year-old male, smoker, with a 10-day history of pain, cyanosis, and progressive digital necrosis in both hands. In the previous four months, he noticed painless mass in the right axillary gap, drenching night sweats, and weight loss. Physical examination at admission highlighted necrotic lesions on the distal phalanges of both hands (except the thumbs), enlarged lymph nodes in right axillary, and right supraclavicular gaps. Arteriography of upper limbs demonstrated a distal stop in all bilateral digital arteries. Digital ischemia was interpreted as a paraneoplastic phenomenon after other common etiologies were ruled out. Amputation of three phalanges was required due to necrosis. Biopsy of axillary nodes demonstrated nodular sclerosis classical Hodgkin's lymphoma (HL). The patient started conventional ABVD protocol (doxorubicin, bleomycin, vinblastine, and dacarbazine). After 6 cycles, he remained asymptomatic and symptoms of digital ischemia were completely resolved. It was concluded that the presence of acral vascular syndromes should alert the physician about the possibility of underlying malignant disease. Prompt investigation and treatment should be rapidly performed to avoid digital sequelae.

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“…In rare circumstances, chronic lymphocytic leukaemia can be associated with cold agglutinin disease [ 17 ]. Acrocyanosis has been observed in Hodgkin’s disease [ 18 ].…”

Section: Hematologic Disordersmentioning

confidence: 99%

Acrocyanosis – A Symptom with Many Facettes

Wollina¹,

Koch²,

Langner³

et al. 2018

Open Access Maced J Med Sci

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Acrocyanosis is an uncommon complaint belonging to the acro-syndromes. It typically presents with coolness and bluish discolourations of hands, feet, ears, nose, lips and nipple. The most frequently affected parts of the body are the hands. This review discusses physical factors, vascular disorders, infectious diseases, haematological disorders, solid tumours genetic disorders, drugs, eating disorders, and spinal disease presenting as or leading to acrocyanosis.

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Acrocyanosis as a presenting symptom of hodgkin lymphoma

Cited by 11 publications

References 5 publications

Acrocyanosis: The Flying Dutchman

Acrocyanosis: The Flying Dutchman

Digital Ischemia as an Unusual Manifestation of Hodgkin’s Lymphoma

Acrocyanosis – A Symptom with Many Facettes

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