Acrokeratosis paraneoplastica (Bazex syndrome) preceeding the diagnosis of metastatic squamous cell carcinoma of the esophagus

Paraneoplastic acrokeratosis of Bazex (Bazex's syndrome): Report of a female case associated with cholangiocarcinoma and review of the published work

“…There are only 11 female cases reported previously 6–8,20,21,25,27,32,35 . The cell types and primary sites of neoplasms in 133 patients with PAB and an analysis of 12 female cases (including our case) are summarized in Table 1 2,5–39 . To our knowledge, our female patient is the first case of PAB associated with adenocarcinoma of choledoch.…”

“…Paraneoplastic acrokeratosis of Bazex is a rare, distinct paraneoplastic dermatosis that has always been reported to be associated with a neoplasm or metastasis. To date, approximately 140 cases, mostly men over 40 years have been reported 2–39 . There are only 11 female cases reported previously 6–8,20,21,25,27,32,35 .…”

Clinical, Imaging, and Pathologic Features of Conditions with Combined Esophageal and Cutaneous Manifestations

“…Acrokeratosis paraneoplastica is a rare paraneo plastic syndrome, one of two conditions known as Bazex syndrome, which was described in 1965 as a specific cutaneous marker of underlying malig nancy involving the aerodigestive tract. It is most commonly associated with SCCs, including SCC of the esophagus (54,65). Acrokeratosis paraneo plastica is characterized by pruritic and painful erythematous hyperkeratotic plaques involving the acral surfaces, specifically the hands, feet, nose, and ears (Fig 31).…”

Un diagnostic dermatologique qui peut d’emblée être évoqué par un médecin ORL

“…À ce jour, moins de 200 cas ont été décrits dans la littérature. Cette dermatose a été décrite pour la première fois en 1924 par Gougerot et Rupp, mais elle a été ensuite rapportée sous le terme de syndrome de Bazex suite à la publication par cet auteur d'un cas d'acrokératose paranéoplasique dans le Bulletin de la Société française de dermatologie et de syphiligraphie en 1965 [1,2]. Le syndrome de Bazex est le plus souvent associé à un cancer des VADS.…”