Acrolein and chloroacetaldehyde: An examination of the cell and cell-free biomarkers of toxicity

MacAllister, Stephanie L.; Martin-Brisac, Nicolas; Lau, Vincent; Yang, Kai; O’Brien, Peter J.

doi:10.1016/j.cbi.2012.11.017

Cited by 43 publications

(37 citation statements)

References 27 publications

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“…Both acroleinand chloroacetaldehyde-induced renal injury is associated with lipid peroxidation and suppression activation of complex I in the mitochondrial respiratory chain resulting in decreased levels of GSH and ATP, and can induce cell death. 56,57 It has been reported that necrosis is the predominant form of cell death by chloroacetaldehyde in human proximal tubular cell lines. 58 Furthermore, chloroacetaldehyde caused elevations of intracellular free Ca2+ by an inhibitory action on Na+/ Ca2+ exchanger, which ultimately led to the disruption of membrane integrity.…”

Section: 50mentioning

confidence: 99%

The effects ofN-acetyl-l-cysteine on the female reproductive performance and nephrotoxicity in rats

Helal

2016

Renal Failure

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This study was designed to investigate whether the treatment with the N-acetyl-L-cysteine prior to the administration of chemotherapy drug would prevent from nephrotoxicity and the loss of reproductive performance induced from chemotherapy treatment. Female rats were divided into five equal groups of six each: 1/control group; 2/rats i.p administered saline solution; 3/rats i.p administered holoxan (50 mg/kg b.wt); 4/rats i.p administered N-acetyl-L-cysteine (160 mg/kg b.wt); 5/rats i.p administered holoxan and N-acetyl-L-cysteine at the same doses. After medications, females rats were allowed to mate with males and the pregnant rats were sacrificed on day 18 of gestation. Premating treatment with holoxan showed reduction (p50.05) in reproductive performance. Whereas administration of N-acetyl-L-cysteine prior to treatment with holoxan and then concurrently with it modulated significantly fertility index, progesterone level, decreasing postimplantation loss, resorbed fetuses and improved fetal growth. Additionally, holoxan elevated the renal nicotinamide dinucleotide phosphate (NADPH) oxidase activity, oxidative stress, renal functions and caused histological changes in renal tissue. N-Acetyl-L-cysteine treatment reduced (p50.05) renal tissue NADPH oxidase, nitric oxide, malondialdehyde and improved super oxide dismutase (SOD) depletion, elevated levels phosphate, total protein and calcium as well as prevented renal histological damages. N-Acetyl-L-cysteine can confer protection against nitrosative and oxidative stresses in renal tissue induced by holoxan by suppressing NADPH oxidase activation, malondialdehyde, nitric oxide and restoring SOD activity which led to the reduction of reactive oxygen species production and subsequently might effectively improve the gonadal hormone disturbance and reproductive functions. ARTICLE HISTORY

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Section: 50mentioning

confidence: 99%

The effects ofN-acetyl-l-cysteine on the female reproductive performance and nephrotoxicity in rats

Helal

2016

Renal Failure

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“…Phosphoramide mustard is mostly associated with CTX's therapeutic effects, while acrolein is linked to the side effects. Acrolein interferes with the tissue antioxidant defense system and induces ROS, which damages mammalian cells, leading to multiple organ toxicity [20]. A lack of detoxifying enzymes leaves the lungs uniquely vulnerable to CTX toxicity [39].…”

Section: Introductionmentioning

confidence: 99%

Blueberry anthocyanins-enriched extracts attenuate the cyclophosphamide-induced lung toxicity

Liu

Shi

et al. 2014

Chemico-Biological Interactions

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“…In this context, MacAllister et al [6] found that carbonyl or amine scavengers offer more protection against chloroacetaldehyde than against acrolein (both substances cause protein damage due to the degradation of glutathione).…”

Section: Ifosfamide and Cyclophosphamide As Anti-cancer Drugsmentioning

confidence: 99%

Mass Spectrometric Detection and Reductive Degradation of the Anti-cancer Drugs Ifosfamide and Cyclophosphamide

Laauser¹,

Habekost²,

Habekost³

2018

AEES

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A flow tube reactor containing iron or zinc powder in a nitrogen atmosphere is capable of performing >90% anaerobic reductive dehalogenation of the cancer drugs ifosfamide and cyclophosphamide at 400 °C using toluene, alcohol or water as proton donors and iron or zinc as reducing agents. The products are all chlorine-free, as proven by GC-MS. The process is particularly interesting for large-scale industrial applications.

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Acrolein and chloroacetaldehyde: An examination of the cell and cell-free biomarkers of toxicity

Cited by 43 publications

References 27 publications

The effects ofN-acetyl-l-cysteine on the female reproductive performance and nephrotoxicity in rats

The effects ofN-acetyl-l-cysteine on the female reproductive performance and nephrotoxicity in rats

Blueberry anthocyanins-enriched extracts attenuate the cyclophosphamide-induced lung toxicity

Mass Spectrometric Detection and Reductive Degradation of the Anti-cancer Drugs Ifosfamide and Cyclophosphamide

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