Across-Line SNP Association Study for Direct and Associative Effects on Feather Damage in Laying Hens

Biscarini, Filippo; Bovenhuis, H.; Poel, Jan van der; Rodenburg, T.B.; Jungerius, Annemieke P; Arendonk, J.A.M. van

doi:10.1007/s10519-010-9370-0

Cited by 74 publications

(91 citation statements)

References 42 publications

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“…However, if many loci influence the trait, dominance variance can be small, despite substantial 2 ), dominance variance will decrease when the number of loci increases and heterosis is constant (Robertson et al 1983;Falconer and Mackay 1996). Hence, this suggests that survival time is affected by many loci, which is consistent with results from Biscarini et al (2010), who found 11 direct QTL and 81 indirect QTL for feather score, which is a precursor of survival. Table 4 shows the estimated parameters, for purebreds, from the direct-indirect animal model.…”

Section: Purebred-crossbred Comparisonsupporting

confidence: 88%

“…These genes can reinforce differences between males and females as, despite a certain degree of dosage compensation, certain parts of the chromosome remain unequally expressed in males and females (Xu et al 2002;Arnold et al 2008). Biscarini et al (2010) found evidence for Z chromosome linked IGEs in an association study on feather condition score in laying hens. Feather condition score serves as a measure for the severity of feather pecking.…”

Section: Genetic Parameters Between Crossesmentioning

confidence: 98%

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Indirect Genetic Effects for Survival in Domestic Chickens (Gallus gallus) Are Magnified in Crossbred Genotypes and Show a Parent-of-Origin Effect

et al. 2012

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Through social interactions, individuals can affect one another's phenotype. The heritable effect of an individual on the phenotype of a conspecific is known as an indirect genetic effect (IGE). Although IGEs can have a substantial impact on heritable variation and response to selection, little is known about the genetic architecture of traits affected by IGEs. We studied IGEs for survival in domestic chickens (Gallus gallus), using data on two purebred lines and their reciprocal cross. Birds were kept in groups of four. Feather pecking and cannibalism caused mortality, as beaks were kept intact. Survival time was shorter in crossbreds than in purebreds, indicating outbreeding depression and the presence of nonadditive genetic effects. IGEs contributed the majority of heritable variation in crossbreds (87 and 72%) and around half of heritable variation in purebreds (65 and 44%). There was no evidence of dominance variance, neither direct nor indirect. Absence of dominance variance in combination with considerable outbreeding depression suggests that survival is affected by many loci. Direct-indirect genetic correlations were moderately to highly negative in crossbreds (20.37 6 0.17 and 20.83 6 0.10), but low and not significantly different from zero in purebreds (0.20 6 0.21 and 20.28 6 0.18). Consequently, unlike purebreds, crossbreds would fail to respond positively to mass selection. The direct genetic correlation between both crosses was high (0.95 6 0.23), whereas the indirect genetic correlation was moderate (0.41 6 0.26). Thus, for IGEs, it mattered which parental line provided the sire and which provided the dam. This indirect parent-of-origin effect appeared to be paternally transmitted and is probably Z chromosome linked.

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Section: Purebred-crossbred Comparisonsupporting

confidence: 88%

Section: Genetic Parameters Between Crossesmentioning

confidence: 98%

Indirect Genetic Effects for Survival in Domestic Chickens (Gallus gallus) Are Magnified in Crossbred Genotypes and Show a Parent-of-Origin Effect

et al. 2012

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“…Like mammals, TIM families in avian species seem to be diverse, with TIM1, TIM3 and TIM4 in a wild bird (zebrafinch) but only TIM1 and TIM4 in the domestic birds (turkey and chicken). Chromosome 13 regions have been linked to genetic control of innate and acquired immunity in layer birds 43. It would be of some interest to determine if there is within‐species variation in TIM1 and TIM4 expression levels that could contribute to immune phenotypes.…”

Section: Discussionmentioning

confidence: 99%

Functional annotation of the T‐cell immunoglobulin mucin family in birds

Vervelde

et al. 2016

Immunology

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SummaryT‐cell immunoglobulin and mucin (TIM) family molecules are cell membrane proteins, preferentially expressed on various immune cells and implicated in recognition and clearance of apoptotic cells. Little is known of their function outside human and mouse, and nothing outside mammals. We identified only two TIM genes (chTIM) in the chicken genome, putative orthologues of mammalian TIM1 and TIM4, and cloned the respective cDNAs. Like mammalian TIM1, chTIM1 expression was restricted to lymphoid tissues and immune cells. The gene chTIM4 encodes at least five splice variants with distinct expression profiles that also varied between strains of chicken. Expression of chTIM4 was detected in myeloid antigen‐presenting cells, and in γδ T cells, whereas mammalian TIM4 is not expressed in T cells. Like the mammalian proteins, chTIM1 and chTIM4 fusion proteins bind to phosphatidylserine, and are thereby implicated in recognition of apoptotic cells. The chTIM4–immunoglobulin fusion protein also had co‐stimulatory activity on chicken T cells, suggesting a function in antigen presentation.

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“…Keeling et al (2004) showed that a QTL for feather damage in chickens coincided with the dominant white pigmentation locus. Biscarini et al (2010) carried out a genome-wide association study and detected different chromosomal regions involved in feather damage in hens.…”

Section: Genetics Of the Behavioural Response To Changes In The Sociamentioning

confidence: 99%

“…This approach, which enables integration of both the animal's performance and its influence on that of other group members in the genetic evaluation, is attractive because it promotes sociality indirectly. Biscarini et al (2010) showed the advantages of a social genetic model used to select against feather pecking in hens. A better understanding of the molecular mechanisms of action of the genes located on GGA1 (which have a strong effect on growth and a wide array of pleiotropic effects on welfare traits) may precede marker-assisted selection (Wiré n and Jensen, 2010).…”

Section: Maternal Behaviourmentioning

confidence: 99%

Genetics of behavioural adaptation of livestock to farming conditions

Canario

Mignon-Grasteau²,

Dupont‐Nivet

et al. 2013

Animal

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Behavioural adaptation of farm animals to environmental changes contributes to high levels of production under a wide range of farming conditions, from highly controlled indoor systems to harsh outdoor systems. The genetic variation in livestock behaviour is considerable. Animals and genotypes with a larger behavioural capacity for adaptation may cope more readily with varying farming conditions than those with a lower capacity for adaptation. This capacity should be exploited when the aim is to use a limited number of species extensively across the world. The genetics of behavioural traits is understood to some extent, but it is seldom accounted for in breeding programmes. This review summarizes the estimates of genetic parameters for behavioural traits in cattle, pigs, poultry and fish. On the basis of the major studies performed in the last two decades, we focus the review on traits of common interest in the four species. These concern the behavioural responses to both acute and chronic stressors in the physical environment (feed, temperature, etc.) and those in the social environment (other group members, progeny, humans). The genetic strategies used to improve the behavioural capacity for adaptation of animals differ between species. There is a greater emphasis on responses to acute environmental stress in fish and birds, and on responses to chronic social stress in mammals.

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Across-Line SNP Association Study for Direct and Associative Effects on Feather Damage in Laying Hens

Cited by 74 publications

References 42 publications

Indirect Genetic Effects for Survival in Domestic Chickens (Gallus gallus) Are Magnified in Crossbred Genotypes and Show a Parent-of-Origin Effect

Indirect Genetic Effects for Survival in Domestic Chickens (Gallus gallus) Are Magnified in Crossbred Genotypes and Show a Parent-of-Origin Effect

Functional annotation of the T‐cell immunoglobulin mucin family in birds

Genetics of behavioural adaptation of livestock to farming conditions

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