Acrosyringium Is the Main Site of the Vesicle/Pustule Formation in Palmoplantar Pustulosis

Murakami, Masamoto; Ohtake, Takaaki; Horibe, Yoshimune; Ishida‐Yamamoto, Akemi; Morhenn, Vera B.; Gallo, Richard L.; Iizuka, Hajime

doi:10.1038/jid.2010.87

Cited by 70 publications

(73 citation statements)

References 32 publications

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“…This suggested that the eosinophilic pustules on the palms and soles in the EPF were anatomically correlated with the eccrine apparatus. Similar findings have been demonstrated in neutrophilic pustules of palmoplantar pustulosis (3). Although eosinophilic infiltration to the dermal eccrine ducts and glands was not seen, intraepidermal eccrine ducts may be the sites predominantly affected by the palmoplantar lesions of EPF.…”

Section: Discussionsupporting

confidence: 61%

Acrosyringeal Involvement of Palmoplantar Lesions of Eosinophilic Pustular Folliculitis

Satoh¹,

Ikeda²,

Yokozeki³

2013

Acta Derm Venerol

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Section: Discussionsupporting

confidence: 61%

Acrosyringeal Involvement of Palmoplantar Lesions of Eosinophilic Pustular Folliculitis

Satoh¹,

Ikeda²,

Yokozeki³

2013

Acta Derm Venerol

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“…Sweat significantly stimulates the production of IL-8, a cytokine that can recruit neutrophils. Several reports show that IL-8 is essential for recruiting neutrophils to the lesional skin in palmoplantar pustulosis [21], [22]. It seems that lesional or systemic IL-8 increases may contribute to the pathogenesis of pustular skin lesions of neutrophilic dermatosis.…”

Section: Discussionmentioning

confidence: 99%

Eccrine Sweat Contains IL-1α, IL-1β and IL-31 and Activates Epidermal Keratinocytes as a Danger Signal

et al. 2013

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Eccrine sweat is secreted onto the skin's surface and is not harmful to normal skin, but can exacerbate eczematous lesions in atopic dermatitis. Although eccrine sweat contains a number of minerals, proteins, and proteolytic enzymes, how it causes skin inflammation is not clear. We hypothesized that it stimulates keratinocytes directly, as a danger signal. Eccrine sweat was collected from the arms of healthy volunteers after exercise, and levels of proinflammatory cytokines in the sweat were quantified by ELISA. We detected the presence of IL-1α, IL-1β, and high levels of IL-31 in sweat samples. To investigate whether sweat activates keratinocytes, normal human keratinocytes were stimulated with concentrated sweat. Western blot analysis demonstrated the activation of NF-κB, ERK, and JNK signaling in sweat-stimulated keratinocytes. Real-time PCR using total RNA and ELISA analysis of supernatants showed the upregulation of IL-8 and IL-1β by sweat. Furthermore, pretreatment with IL-1R antagonist blocked sweat-stimulated cytokine production and signal activation, indicating that bioactive IL-1 is a major factor in the activation of keratinocytes by sweat. Moreover, IL-31 seems to be another sweat stimulator that activates keratinocytes to produce inflammatory cytokine, CCL2. Sweat is secreted onto the skin's surface and does not come into contact with keratinocytes in normal skin. However, in skin with a defective cutaneous barrier, such as atopic dermatitis-affected skin, sweat cytokines can directly act on epidermal keratinocytes, resulting in their activation. In conclusion, eccrine sweat contains proinflammatory cytokines, IL-1 and IL-31, and activates epidermal keratinocytes as a danger signal.

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“…This protein is specifically and constitutively expressed in the sweat glands and secreted into sweat . Murakami et al . studied the sweat secretion in the pathomechanism of palmoplantar pustulosis by using dermcidin as a marker for sweat.…”

Section: Discussionmentioning

confidence: 99%

“…Interestingly, immunohistochemical staining of dermcidin (mouse monoclonal antibody to dermcidin [G‐81]; Santa Cruz Biotechnology, Dallas, TX, USA) confirmed sweat leakage in the subpapillary dermis in the affected area (Fig. c,d) . In contrast, dermcidin was detected in the eccrine sweat duct and eccrine sweat glands but not in the dermis in the unaffected area (Fig.…”

Section: Case Reportmentioning

confidence: 99%

Hypohidrosis and metal allergy: Trigger factors for unilateral lichen planus

Fukumoto

Tsuchiyama

Fukunaga

et al. 2017

The Journal of Dermatology

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Unilateral lichen planus (LP) is a rare clinical variant of LP. The etiology of unilateral LP has not been clarified, although various causes have been reported because of the characteristic distribution. We focused on the contribution of metal allergy and sweating in the development of unilateral LP in this case. To confirm the presence of metal allergy, patch tests with metal allergens were performed. To investigate the cause of the unilateral distribution in unilateral LP, the function of sweating and sweat leaking in the dermis was assessed by a thermoregulatory sweat test and immunohistochemical staining of dermcidin. The patch tests with SnCl , H PtCl , ZnCl and MnCl were positive. The thermoregulatory sweat test using the starch-iodine method (Minor test) with sweating provoked by heat stimulation revealed hypohidrosis of the affected area, whereas no skin lesions were observed on the dorsal hand and wrist where sweating was normal. Histopathological examination showed keratin plugging of the acrosyringium and lymphocytic infiltrations in the papillary and subpapillary dermis around the intraepidermal and intradermal eccrine duct in the affected area. The immunohistochemical staining of dermcidin confirmed sweat leakage in the subpapillary dermis in the affected area. The symptoms refractory to the topical steroids were markedly improved after removal of the dental metals. The coexistence of metal allergy and sweat leakage in the hypohidrotic area may be involved in the development of unilateral LP.

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Acrosyringium Is the Main Site of the Vesicle/Pustule Formation in Palmoplantar Pustulosis

Cited by 70 publications

References 32 publications

Acrosyringeal Involvement of Palmoplantar Lesions of Eosinophilic Pustular Folliculitis

Acrosyringeal Involvement of Palmoplantar Lesions of Eosinophilic Pustular Folliculitis

Eccrine Sweat Contains IL-1α, IL-1β and IL-31 and Activates Epidermal Keratinocytes as a Danger Signal

Hypohidrosis and metal allergy: Trigger factors for unilateral lichen planus

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