Acrylic polymer-grafted polypropylene sutures for covalent immobilization or reversible adsorption of vancomycin

García-Vargas, Miriam; González-Chomón, Clara; Magariños, Beatríz; Bucio, Emilio

doi:10.1016/j.ijpharm.2013.11.060

Cited by 48 publications

(33 citation statements)

References 29 publications

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“…Ophthalmic drug‐eluting sutures containing levofloxacin loaded poly (L‐ lactic acid) and polyethylene glycol made from biocompatible polymers with hydrophilic polymer (microfiber) for use in ocular surgery inhibited the bacterial growth ( S. epidermidis ) and infection rate in rats . Vancomycin grafted onto polypropylene suture with acrylic polymer by ionic interaction with acrylic acid moieties but not by covalent immobilization through glycidyl groups of glycidyl methacrylate reported sustained release of the drug …”

Section: Recent and Emerging Trendsmentioning

confidence: 99%

Suture materials — Current and emerging trends

Christopher

Sethu

Nayak

et al. 2016

J Biomedical Materials Res

158

108

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Surgical sutures are used to facilitate closure and healing of surgical-or trauma-induced wounds by upholding tissues together to facilitate healing process. There is a wide range of suture materials for medical purpose and the main types include absorbable and nonabsorbable. Recently, there is a growth in the development of classes of suture materials based on their properties and capabilities to improve tissue approximation and wound closure. This review outlines and discusses the current and emerging trends in suture technology including knotless barbed sutures, antimicrobial sutures, bio-active sutures such as drug-eluting and stem cells seeded sutures, and smart sutures including elastic, and electronic sutures. These newer strategies expand the versatility of sutures from being used as just a physical entity approximating opposing tissues to a more biologically active component enabling delivery of drugs and cells to the desired site with immense application potential in both therapeutics and diagnostics.

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Section: Recent and Emerging Trendsmentioning

confidence: 99%

Suture materials — Current and emerging trends

Christopher

Sethu

Nayak

et al. 2016

J Biomedical Materials Res

158

108

View full text Add to dashboard Cite

show abstract

“…Xin et al [16] Carboxymethyl chitosan (OCMCHI) on poly(ethylene terephthalate) films surface-activated by argon plasma followed by graft copolymerization with acrylic acid (AAc) [18]. However, the most of the researchers reported the grafting of AAc and PEG by the direct immersion methods [19][20][21][22][23][24][25].…”

Section: Introductionmentioning

confidence: 99%

Low-pressure plasma enhanced immobilization of chitosan on low-density polyethylene for bio-medical applications

Pandiyaraj¹,

Ferraria

Rego

et al. 2015

Applied Surface Science

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“…Although still little explored, grafting of N ‐vinylpyrrolidone or 2‐(dimethylaminoethyl)methacrylate onto SR by means of gamma rays has been shown useful to prepare implantable medical devices with anti‐biofouling properties . Compared to those previously tested polymers, PMAA is particularly suitable for biomedical applications since the carboxylic acid groups can be further conjugated with bioactive substances such as drugs, peptides, or antibodies . Despite grafting of PMMA on SR has been previously explored, the reports on loading and release of antimicrobial agents are still quite few.…”

Section: Introductionmentioning

confidence: 99%

Silicone Rubber Modified with Methacrylic Acid to Host Antiseptic Drugs

Vázquez-González

Meléndez‐Ortiz

Díaz-Gómez

et al. 2014

Macro Materials & Eng

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Silicone rubber (SR) was γ‐ray grafted with poly(methacrylic acid) (PMAA) to improve its ability to host antimicrobial drugs. Dependence of grafting yield on monomer concentration, pre‐irradiation dose, temperature and reaction time was evaluated. Modified SR films were characterized by means of FT‐IR, DSC, TGA, SEM, contact angle measurements, and swelling studies. SR‐g‐MAA showed pH sensitivity (critical pH ∼6) and good cytocompatibility. Soaking of SR‐g‐MAA in benzalkonium chloride and vancomycin aqueous solutions led to high loadings; up to 5.8 and 15.2 mg cm‐2, respectively. SR‐g‐MAA released 100% vancomycin after 24 h in buffer pH 7.4 at 37 °C, but only 20% benzalkonium chloride due to strong ionic interactions. Drug‐loaded SR‐g‐MAA prevented in vitro growth of Staphylococcus aureus. Overall, grafting of PMAA may improve the performance of SR for biomedical applications.

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Acrylic polymer-grafted polypropylene sutures for covalent immobilization or reversible adsorption of vancomycin

Cited by 48 publications

References 29 publications

Suture materials — Current and emerging trends

Suture materials — Current and emerging trends

Low-pressure plasma enhanced immobilization of chitosan on low-density polyethylene for bio-medical applications

Silicone Rubber Modified with Methacrylic Acid to Host Antiseptic Drugs

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