Silicone Rubber Modified with Methacrylic Acid to Host Antiseptic Drugs

Abstract

Silicone rubber (SR) was γ‐ray grafted with poly(methacrylic acid) (PMAA) to improve its ability to host antimicrobial drugs. Dependence of grafting yield on monomer concentration, pre‐irradiation dose, temperature and reaction time was evaluated. Modified SR films were characterized by means of FT‐IR, DSC, TGA, SEM, contact angle measurements, and swelling studies. SR‐g‐MAA showed pH sensitivity (critical pH ∼6) and good cytocompatibility. Soaking of SR‐g‐MAA in benzalkonium chloride and vancomycin aqueous solutions led to high loadings; up to 5.8 and 15.2 mg cm‐2, respectively. SR‐g‐MAA released 100% vancomycin after 24 h in buffer pH 7.4 at 37 °C, but only 20% benzalkonium chloride due to strong ionic interactions. Drug‐loaded SR‐g‐MAA prevented in vitro growth of Staphylococcus aureus. Overall, grafting of PMAA may improve the performance of SR for biomedical applications.

Radiation Grafting of a Polymeric Prodrug onto Silicone Rubber for Potential Medical/Surgical Procedures

“…Regarding the swelling test, films with and without grafting were placed in 20 mL of distilled water at room temperature and weighed at different time intervals (15 to 240 min). The following equation, Equation (2) [ 29 ], determined the swelling percentage: where corresponds to the weight of the swollen film and corresponds to the weight of the dry film.…”

Radiation-grafting of acrylamide onto silicone rubber films for diclofenac delivery

“…Possibility of obtaining synergic therapeutic effects has prompted an intense research on methods of loading sufficient amount of drugs and of controlling their release from the medical device Concheiro and Alvarez-Lorenzo, 2013;Vazquez-Gonzalez et al, 2014). In addition to compounding, surface modification of materials commonly used to prepare the medical devices is attracting increasing attention as a way to provide binding points to drugs and to regulate protein and cell adsorption (Elbert and Hubbell, 1996;Burt and Hunter, 2006).…”

Direct laser etching of hierarchical nanospheres on silicon rubber surface with robust dynamic superhydrophobic stability

“…Chemical resistance, cold resistance, antimicrobial, and good processability have made silicone rubbers very attractive materials in engineering applications. [1][2][3] However, the formation and accumulation of rain, ice, fog, and dust can easily cause serious damage to the silicone rubber products, such as power lines, sealing elements, automotive, and aviation. [4][5][6][7] Diverging from biological surfaces, such as lotus leaf and rose petal, superhydrophobic surfaces with a water contact angle (CA) higher than 150 have received considerable attention due to their importance in both fundamental research and practical applications, such as self-cleaning surface, oil-water separation, anti-icing surface, and liquid transportation.…”