Acrylonitrile adducts: design, synthesis and biological evaluation as antimicrobial, haemolytic and thrombolytic agent

Das, Parineeta; Devi, Nirmala; Gaur, Nisha; Goswami, Swagata; Dutta, Dhiraj; Dubey, Rama; Пузари, Амрит

doi:10.1038/s41598-023-33605-1

Cited by 4 publications

(2 citation statements)

References 60 publications

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“…22–24 It is reported that nitrile group modified complexes show good antibacterial activity against Gram-positive and Gram-negative bacteria. 25–27 Importantly, the nitrile group can be used as bioactive “warheads” to hydrogen bond with proteins. 28 The nitrile group has significant effects on bacterial communities due to its conjugation effects.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and anti-infective potency study of a Ru-based complex bearing benzonitrile against Staphylococcus aureus

Huang,

Jiang,

Song

et al. 2023

New J. Chem.

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Section: Introductionmentioning

confidence: 99%

Synthesis and anti-infective potency study of a Ru-based complex bearing benzonitrile against Staphylococcus aureus

Huang,

Jiang,

Song

et al. 2023

New J. Chem.

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“…Refs. [ 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , <...…”

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Fungal-Bacterial Combinations in Plant Health under Stress: Physiological and Biochemical Characteristics of the Filamentous Fungus Serendipita indica and the Actinobacterium Zhihengliuella sp. ISTPL4 under In Vitro Arsenic Stress

Sharma,

Koul,

Joshi

et al. 2024

Microorganisms

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Fungal-bacterial combinations have a significant role in increasing and improving plant health under various stress conditions. Metabolites secreted by fungi and bacteria play an important role in this process. Our study emphasizes the significance of secondary metabolites secreted by the fungus Serendipita indica alone and by an actinobacterium Zhihengliuella sp. ISTPL4 under normal growth conditions and arsenic (As) stress condition. Here, we evaluated the arsenic tolerance ability of S. indica alone and in combination with Z. sp. ISTPL4 under in vitro conditions. The growth of S. indica and Z. sp. ISTPL4 was measured in varying concentrations of arsenic and the effect of arsenic on spore size and morphology of S. indica was determined using confocal microscopy and scanning electron microscopy. The metabolomics study indicated that S. indica alone in normal growth conditions and under As stress released pentadecanoic acid, glycerol tricaprylate, L-proline and cyclo(L-prolyl-L-valine). Similarly, d-Ribose, 2-deoxy-bis(thioheptyl)-dithioacetal were secreted by a combination of S. indica and Z. sp. ISTPL4. Confocal studies revealed that spore size of S. indica decreased by 18% at 1.9 mM and by 15% when in combination with Z. sp. ISTPL4 at a 2.4 mM concentration of As. Arsenic above this concentration resulted in spore degeneration and hyphae fragmentation. Scanning electron microscopy (SEM) results indicated an increased spore size of S. indica in the presence of Z. sp. ISTPL4 (18 ± 0.75 µm) compared to S. indica alone (14 ± 0.24 µm) under normal growth conditions. Our study concluded that the suggested combination of microbial consortium can be used to increase sustainable agriculture by combating biotic as well as abiotic stress. This is because the metabolites released by the microbial combination display antifungal and antibacterial properties. The metabolites, besides evading stress, also confer other survival strategies. Therefore, the choice of consortia and combination partners is important and can help in developing strategies for coping with As stress.

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Synthesis, Characterization, Biological Evaluation, DFT, and Molecular Docking Study of a Co(II) Complex Derived from ON Donor Bidentate Schiff Base Ligand

Ismaila,

Mala,

Umaru

et al. 2024

ChemistrySelect

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The utilization of biologically active metal complexes in medicine is gaining recognition as an alternative approach to traditional biologically active organic molecules, which often exhibit undesirable side effects. This study focuses on the synthesis and characterization of a Co(II) complex derived from the (E)‐2‐((2‐hydroxybenzylidene)amino)‐5‐methylbenzonitrile ligand system (HL) and cobalt(II) acetate tetrahydrate in a dichloromethane/methanol solution. A comprehensive characterization strategy was employed, involving proton and carbon nuclear magnetic resonance, infrared, electronic spectra, PXRD, SEM‐EDX, and mass spectroscopies, as well as elemental analysis (CHN and Co), TGA, and molar conductance, to confirm the chemical structures of the ligand and its complex. The infrared spectral data revealed the ligand as a bidentate ligand, chelating the Co(II) ion through the oxygen and nitrogen atoms of the phenolate and imine groups. Additionally, PXRD and SEM analyses indicated crystalline and amorphous properties for the ligand and complex, respectively. Assessment of antimicrobial potential using a modified disc diffusion method, with streptomycin as the positive control, demonstrated the complex's enhanced antibacterial activity compared to the ligand against all tested bacteria, showing a concentration‐dependent response. Similarly, antioxidant studies revealed promising results, with the complex exhibiting superior DPPH radical scavenging activity (IC50 values: ligand 64.5 μg.mL−1, complex 43.1 μg.mL−1). Theoretical analysis through DFT calculations and molecular docking provided insights into the electronic properties and binding affinity of the ligand and complex, supporting the experimental findings and affirming the biological activities exhibited by the compounds. Overall, this research showcases the synthesis, characterization, and biological evaluation of a promising Co(II) complex, highlighting its potential as an effective antimicrobial and antioxidant agent.

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Acrylonitrile adducts: design, synthesis and biological evaluation as antimicrobial, haemolytic and thrombolytic agent

Cited by 4 publications

References 60 publications

Synthesis and anti-infective potency study of a Ru-based complex bearing benzonitrile against Staphylococcus aureus

Synthesis and anti-infective potency study of a Ru-based complex bearing benzonitrile against Staphylococcus aureus

Fungal-Bacterial Combinations in Plant Health under Stress: Physiological and Biochemical Characteristics of the Filamentous Fungus Serendipita indica and the Actinobacterium Zhihengliuella sp. ISTPL4 under In Vitro Arsenic Stress

Synthesis, Characterization, Biological Evaluation, DFT, and Molecular Docking Study of a Co(II) Complex Derived from ON Donor Bidentate Schiff Base Ligand

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