Actinic prurigo among the Chimila Indians in Colombia: HLA studies

Bernal, Jaime; Rueda, María Melida Durán de; Ordonez, Clara; Durán, Clemencia; Brigard, Delia de

doi:10.1016/0190-9622(90)70150-g

Cited by 49 publications

(30 citation statements)

References 5 publications

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“…In Cree Indians from Saskatchewan, Canada (9), the most common antigens were HLA‐A24 and HLA‐Cw4. In the Chimila Indians from Colombia (10), a high frequency of HLA‐Cw4 was found, and in Mexicans we reported an increased occurrence of HLA‐A28 and HLA‐B39(B16), as well as a very strong association with HLA‐DR4 (DRB1*0407) (11).…”

Section: Immunogenetics and Pathophysiologymentioning

confidence: 65%

Diagnosis and treatment of actinic prurigo

et al. 2003

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Actinic prurigo (AP) is an idiopathic photodermatosis that affects mainly the mestizo population in Latin America. It has an early onset, a slight predominance in women, and affects the sun-exposed areas of the skin, causing erythematous papules and lichenified plaques secondary to intense and chronic pruritus. Lesions can be induced by both ultraviolet A (UVA) and ultraviolet B (UVB). An association with several human leukocyte antigen (HLA) alleles has been reported. AP is unique among all photodermatoses in its remarkable response to thalidomide. In the past the microscopic features of AP have been considered as nonspecific; however, the constant finding of dense lymphocytic inflammatory infiltrates and the immunogenetic features of AP support the existence of an immunologic mechanism in its pathogenesis.

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Section: Immunogenetics and Pathophysiologymentioning

confidence: 65%

Diagnosis and treatment of actinic prurigo

et al. 2003

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“…There is a much wider range of polymorphism of the HLA genes in the present groups compared to the previous studies in Amerindians [6][7][8], Geographical proximity seems to play a greater role in the genetic affinity than the linguistic similarity. The moderately high genetic differentiation is due to the wide variation in frequencies of antigens commonly found in all five groups and an extremely high value of particular antigens in certain Amerindian groups (e.g.…”

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confidence: 40%

“…The studies about genetic variability among the Indian populations of Colombia were started by Kirk et al [2]; however, more recently several surveys analysed various ge netic markers in different urban and Amerin dian groups [3][4][5], In Colombia, the genes of the major histocompatibility complex (HLA) have been the subject of four studies, but only three Indian groups, Uitoto, Awa-Kwaikerand Chimila, have been investigated [6][7][8], In 1988 the Universidad Javeriana launched a 5-year programme 'Expedición Humana' in which several Amerindian groups have been simulta neously studied for immunogenetic markers specially for the HLA-A, B, C and D loci. The present study reports the frequency variation among five Amerindian populations, three in habiting the northeast border between Colom bia and Venezuela (Yuko, Tunebo and Bari), while the other two (Guane and Paez) occupy a more central region of the country.…”

Section: Introductionmentioning

confidence: 99%

HLA Antigens in Five Amerindian Groups (Yuko, Bari, Tunebo, Guane and Paez) of Colombia: Results of ‘&Egr;xpedición Humana’

Bernal

Durán²,

Briceño

et al. 1995

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The serological HLA types (A, B, C and D loci) were studied in five different Indian groups in Colombia. The range of polymorphism was not very restricted in these groups, but there was significant genetic heterogeneity among the five populations in all the HLA loci. The gene frequency data, when converted into a kinship matrix and a two-dimensional eigenvector plot, showed a closer affinity between Bari and Yuko Indians, while Guane, Tunebo and Paez Indians were not only genetically different from the former but also well-differentiated from each other. It seems therefore from this study that geographical proximity may play a greater role than linguistic similarities in the genetic affinities of Colombian Amerindians.

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“…The allusion of Moncada et al . to a hypothetical “disregard syndrome” is invalidated by their own disregard, as we could not find a single reference in their article on AP to our previous studies, 6–9 or to the previous investigations of others, even in their own country 10,11 …”

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confidence: 85%