Actinic prurigo

Association of HLA subtype DRB1*0407 in Colombian patients with actinic prurigo

“…A ctinic prurigo is a chronic photodermatosis of unknown etiology, frequent in Latin American mestizos (Caucasians and indigenous offspring) and in Amerindians (1,2) living at high altitudes. As a possible physiopathogenic mechanism, a delayed hypersensitivity reaction upon autoantigens induced by ultraviolet radiation in persons with genetic susceptibility has been proposed (3)(4)(5)(6)(7).…”

“…This disease is characterized by pruritic symmetric skin lesions, predominant in exposed areas that also affect the lips and the conjunctivae. Clinical findings usually appear in childhood or before 20 years of age (8), although there is a group of patients in which the disease begins late in life (1,9). The sun-related exacerbation of this condition affects the quality of life of these patients.…”

Verrucous Epidermal Nevus With Unusual Features

“…The response of our patient to photoprotection measures and to topical steroids and emollients was striking. As previously suggested, patients with AP can be distinguished into two main groups: the early-onset and the late-onset group (6). The early-onset group includes those with disease onset before 20 years of age and has a more favorable prognosis.…”

“…The early-onset group includes those with disease onset before 20 years of age and has a more favorable prognosis. Of patients in this category, 62% may grow out of their condition after about a 5year course (6). This is unusual for the late-onset group who seem to have a more protracted course.…”

“…Broad-spectrum sunscreens and rigorous photoprotection together with strong topical steroids may be helpful in some patients, whereas in others, antimalarials, betacarotenes, or psoralen and ultraviolet A therapy have been tried with variable results (4)(5)(6). The therapeutic efficacy of thalidomide in AP is striking and is considered by some diagnostic (5).…”