Actinidia arguta extract attenuates inflammasome activation: Potential involvement in NLRP3 ubiquitination

Heo, Kang-Hyuck; Sun, Xiao; Shim, Do-Wan; Kim, Myong-Ki; Koppula, Sushruta; Yu, Sang–Hyeun; Kim, Han-Bi; Kim, Tack-Joong; Kang, Tae-Bong; Lee, Kwang-Ho

doi:10.1016/j.jep.2017.11.023

Cited by 26 publications

(18 citation statements)

References 43 publications

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“…SYBYL-X 2.1.1 (Tripos Ltd., St. Louis, MO, USA) with crystal structures of N-terminal subunit (NtMGAM; PDB-ID: 2QMJ) and C-terminal subunit (CtMGAM; PDB-ID: 3TOP) of human maltase-glucoamylase (MGAM) were used, respectively, for molecular docking studies of active compounds [ 19 ].…”

Section: Methodsmentioning

confidence: 99%

“…The HMBC correlations from H-1 of a glucose to C-7 of a 6,7-dihydroxycoumarin group suggested the linkage between 6,7-dihydroxycoumarin and a glucose, and the HMBC correlations from H-6 of a glucose to C-9" of trans-caffeoyl group suggested the linkage between a glucose and a trans-caffeoyl group. Based on these data, the structure of compound 5 was defined as esculetin 7-O-(6 -O-trans-caffeoyl)-βglucopyranoside and named argutoside E. The known compounds were identified as esculetin 7-O-(6 -O-trans-coumaroyl)-βglucopyranoside (6) [23], umbelliferone 7-O-(6 -O-trans-coumaroyl)-β-glucopyranoside (7) [23], esculetin (8) [22], 7,8-Dihydroxycoumarin (9) [24], umbelliferone (10) [25], 4hydroxybenzoic acid (11) [26], protocatechuic acid (12) [26], vanillic acid (13) [27], isovanillic acid (14) [28], hydroxytyrosol (15) [28], (-)-rhodolatouchol (16) [29], p-E-coumaric acid (17) [30], p-E-coumaric acid-9-O-glucopyranoside (18) [23], E-caffeic acid (19) [28], E-ferulic acid (20) [31], 3,5-dimethoxy-4-hydroxycinnamic alcohol (21) [32], kaempferol (22) [33], kaempferol 3-O-β-glucopyranoside (23) [34], kaempferol 3-O-β-galactopyranoside (24) [35], quercetin (25) [36], tamarixin (26) [37], isorhamnetin 3-O-β-glucopyranoside (27) [30], rhamne...…”

Section: Structural Determination Of New Compoundsmentioning

confidence: 99%

“…Due to its cold-resistant characteristic, it can be cultivated in Northeast Asia [ 16 , 17 ]. The grains of A. arguta are mainly consumed as fresh fruits while the cooked leaves are used in the treatment of various diseases with antioxidant, antibacterial, antidiabetic and anti-inflammatory effects [ 18 , 19 , 20 ]. We recognized the importance of A. arguta as a native plant together with its biological activities and, thus, investigated the efficacy and ingredients of A. arguta .…”

Section: Introductionmentioning

confidence: 99%

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Aromatic Constituents from the Leaves of Actinidia arguta with Antioxidant and α-Glucosidase Inhibitory Activity

et al. 2021

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As the leaf of Actinidia arguta has shown antioxidant activity, a study was conducted to identify the active ingredients. Forty-eight compounds were isolated from the leaves of A. arguta through various chromatographic techniques. Further characterization of the structures on the basis of 1D and 2D NMR and MS data identified several aromatic compounds, including phenylpropanoid derivatives, phenolics, coumarins, flavonoids and lignans. Among them, five compounds were newly reported, naturally occurring, and named argutosides A–D (1–4), which consist of phenylpropanoid glycosides that are conjugated with a phenolic moiety, and argutoside E (5), which is a coumarin glycoside that is conjugated with a phenylpropanoid unit. The isolated compounds showed good antioxidant and α-glucosidase inhibitory activity with differences in activity depending on the structures. Molecular docking analysis demonstrated the interaction between the hydroxyl and carbonyl groups of compounds 1 and 5 with α-glucosidase. Taken together, the leaves of A. arguta are rich in aromatic compounds with diverse structures. Therefore, the leaves of A. arguta and their aromatic components might be beneficial for oxidative stress and glucose-related diseases.

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Section: Methodsmentioning

confidence: 99%

Section: Structural Determination Of New Compoundsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Aromatic Constituents from the Leaves of Actinidia arguta with Antioxidant and α-Glucosidase Inhibitory Activity

et al. 2021

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“…ex Miq [Actinidiaceae] (AA) is known to have abundant nutrients, such as vitamins, polyphenols, etc. An existing study reported that AA regulated NLRP3 ubiquitination and ASC oligomerization, leading to the inhibition of NLRP3 inflammasome-mediated IL-1β secretion in the MSU-induced gout mice model ( Heo et al, 2018 ).…”

Section: Natural Extract Treatment Studies For Nlrp3 Inflammasome Reg...mentioning

confidence: 99%

Natural Products as a Novel Therapeutic Strategy for NLRP3 Inflammasome-Mediated Gout

et al. 2022

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Gout is the most common form of inflammatory arthritis. It occurs when monosodium urate crystals (MSU) are deposited within joints due to hyperuricemia and persistent elevations of serum uric acid levels. Traditional gout treatment such as urate-lowering therapy is difficult to continue for a long period of time due to the risk of side effects. Recent studies have shown that the modulation of MSU-induced inflammatory responses is dependent on the inflammatory cytokine IL-1β, which has a central role in a chain of processes involving multiple cytokines and mediators. In this regard, the NLRP3 inflammasome is known to play a crucial part and thus has been proposed as a novel target in the treatment for gout. However, the biochemical mechanism for NLRP3 inflammasome activation has not yet been clearly elucidated. Therefore, this report can provide an overview of natural extractions targeted to prevent or treat NLRP3 inflammasome-mediated gout in the MSU-induced gout model. In addition, the research and development of such natural products are suggested as a potential strategy in the treatment of gout.

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“…The richness in biologically active compounds is directly related to the biochemical and physiological effects and, accordingly, human health benefits of hardy kiwifruits. Different authors have described biological activities for A. arguta fruit, including anticancer, anti‐inflammatory and antioxidant activities [10–13] …”

Section: Introductionmentioning

confidence: 99%

Actinidia arguta Pulp: Phytochemical Composition, Radical Scavenging Activity, and in Vitro Cells Effects

Pinto

Sut

Dall’Acqua

et al. 2021

Chemistry & Biodiversity

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Hardy kiwifruit (Actinidia arguta) is a highly appreciated exotic fruit endowed with outstanding bioactive compounds. The present work proposes to characterize the pulp from A. arguta organic fruits, emphasizing its radicals scavenging capacity and effects on intestinal cells (Caco‐2 and HT29‐MTX). The physicochemical properties and phenolic profile were also screened. The total phenolic and flavonoid contents (TPC and TFC, respectively) of pulp were 12.21 mg GAE/g on dry weight (DW) and 5.92 mg CE/g DW, respectively. A high antioxidant activity was observed (FRAP: 151.41 μmol FSE/g DW; DPPH: 12.17 mg TE/g DW). Furthermore, the pulp did not induce a toxic effect on Caco‐2 and HT29‐MTX cells viability up to 1000 μg/mL. Regarding in vitro scavenging capacity, the pulp revealed the highest scavenging power against NO. (IC50=3.45 μg/mL) and HOCl (IC50=12.77 μg/mL). These results emphasize the richness of A. arguta fruit pulp to be used in different food products.

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Actinidia arguta extract attenuates inflammasome activation: Potential involvement in NLRP3 ubiquitination

Cited by 26 publications

References 43 publications

Aromatic Constituents from the Leaves of Actinidia arguta with Antioxidant and α-Glucosidase Inhibitory Activity

Aromatic Constituents from the Leaves of Actinidia arguta with Antioxidant and α-Glucosidase Inhibitory Activity

Natural Products as a Novel Therapeutic Strategy for NLRP3 Inflammasome-Mediated Gout

Actinidia arguta Pulp: Phytochemical Composition, Radical Scavenging Activity, and in Vitro Cells Effects

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