2011
DOI: 10.1128/jcm.00798-11
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Actinobaculum Bacteremia: a Report of 12 Cases

Abstract: Actinobaculum species are anaerobic Gram-positive rods that have previously been associated with urinary tract infection (UTI) in the elderly. We report 12 patients with Actinobaculum bacteremia. Only 40% of blood cultures were clinically considered significant by the treating physicians, but most patients were treated for UTI, suggesting a possible urinary source of bacteremia. Clinicians should be aware of the pathogenic potential of Actinobaculum spp.

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Cited by 47 publications
(38 citation statements)
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“…Our findings of clinically significant A. schaalii isolates from blood are consistent with data in the literature, and we recommend the identification of A. schaalii isolates to the species level, especially when detected in blood or urine (9,39).…”
Section: Discussionsupporting
confidence: 80%
“…Our findings of clinically significant A. schaalii isolates from blood are consistent with data in the literature, and we recommend the identification of A. schaalii isolates to the species level, especially when detected in blood or urine (9,39).…”
Section: Discussionsupporting
confidence: 80%
“…As a result of the difficulties in accurate identification by traditional phenotypic methods in clinical microbiology laboratories, the clinical significance and pathogenicity of these bacteria, especially the less commonly encountered species, have been poorly understood. Based on 16S rRNA gene analysis as a new standard for classification of bacteria (20,21), many of these bacteria have undergone taxonomic revisions with new genera and species having been introduced (9,10,12,18,24,26,29), and rarely encountered species have become better understood in terms of their disease association and epidemiology (4,5,15,19,22,25,28).…”
mentioning
confidence: 99%
“…however, the pair of oligonucleotide primers that meet those criteria most efficiently was already published in the literature for other purposes (2,3,8). An almost identical primer sequence was originally described for detection of Mycobacteria in medical diagnostics (2,12), as well as for molecular detection of different Gram-positive and Gramnegative, anaerobic or aerobic bacteria in clinical samples (8). In addition, the same pair of primers was used for amplification of DNA from unknown species of luminescent marine bacteria (3).…”
Section: And Discussionmentioning
confidence: 99%
“…We have performed extensive in silico analysis of the bacterial 16SrRNA gene database searching for primer pairs that could anneal most efficiently yet amplifying most of the variable sequence, hence enabling identification of as many as possible bacterial species. however, the pair of oligonucleotide primers that meet those criteria most efficiently was already published in the literature for other purposes (2,3,8). An almost identical primer sequence was originally described for detection of Mycobacteria in medical diagnostics (2,12), as well as for molecular detection of different Gram-positive and Gramnegative, anaerobic or aerobic bacteria in clinical samples (8).…”
Section: And Discussionmentioning
confidence: 99%
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