Action-based organization of a cerebellar module specialized for predictive control of multiple body parts

Heiney, Shane A.; Wojaczynski, Gregory J; Medina, Javier F.

doi:10.1016/j.neuron.2021.08.017

Cited by 25 publications

(16 citation statements)

References 64 publications

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“…It integrates visual, auditory, and sensorimotor information in order to orient [298][299][300]. The cerebellar nuclei project strongly to all layers of the superior colliculus [11,32,33,44,48,49,54,65,67,77,79,83,92,173,207,208,233,237,243,275,294,[301][302][303][304][305][306][307][308][309][310][311] Periaqueductal Gray (PAG)…”

Section: Superior Colliculus (Sc)mentioning

confidence: 99%

A Systematic Review of Direct Outputs from the Cerebellum to the Brainstem and Diencephalon in Mammals

2022

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The cerebellum is involved in many motor, autonomic and cognitive functions, and new tasks that have a cerebellar contribution are discovered on a regular basis. Simultaneously, our insight into the functional compartmentalization of the cerebellum has markedly improved. Additionally, studies on cerebellar output pathways have seen a renaissance due to the development of viral tracing techniques. To create an overview of the current state of our understanding of cerebellar efferents, we undertook a systematic review of all studies on monosynaptic projections from the cerebellum to the brainstem and the diencephalon in mammals. This revealed that important projections from the cerebellum, to the motor nuclei, cerebral cortex, and basal ganglia, are predominantly di- or polysynaptic, rather than monosynaptic. Strikingly, most target areas receive cerebellar input from all three cerebellar nuclei, showing a convergence of cerebellar information at the output level. Overall, there appeared to be a large level of agreement between studies on different species as well as on the use of different types of neural tracers, making the emerging picture of the cerebellar output areas a solid one. Finally, we discuss how this cerebellar output network is affected by a range of diseases and syndromes, with also non-cerebellar diseases having impact on cerebellar output areas.

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Section: Superior Colliculus (Sc)mentioning

confidence: 99%

A Systematic Review of Direct Outputs from the Cerebellum to the Brainstem and Diencephalon in Mammals

2022

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“…Thus, granule cells may be capable of parcellating behavior and binding specific sensorimotor features to upcoming reward, providing an even richer set of parameters for Purkinje cell microzones to learn. These learned pattern combinations could then be routed out to various extracerebellar targets via specific modules, binding specific motor synergies to rewarding outcomes (De Zeeuw, 2021;Heiney et al, 2021).…”

Section: Reward Signals In the Mossy Fiber-granule Cell Pathwaymentioning

confidence: 99%

Reward signals in the cerebellum: Origins, targets, and functional implications

Kostadinov¹,

Häusser²

2022

Neuron

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“…On the other hand, our findings support previously observed learning-associated sprouting of MFs on both sides of the CN, with also a contralateral preponderance 20 . Possibly, the bilateral effects are part of the recently uncovered mechanism that local eyeblink conditioning can lead to more widespread defensive behavior, engaging multiple parts of the whole body 62 .…”

Section: Discussionmentioning

confidence: 99%

Synaptic mechanisms for associative learning in the cerebellar nuclei

Broersen

Carulli

Canto

et al. 2022

Preprint

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Learning to associate a cue with its aversive consequence enables animals to prevent harm. Associative conditioning relies on activity within the cerebellum, but little is known about how changes in synaptic inputs to its output neurons shape their membrane potential dynamics during learning. Here we studied these changes in inputs using whole-cell and juxtasomal recordings of cerebellar nucleus neurons in awake mice during eyeblink conditioning and doing post-learning structural analysis. We identified changes in mossy fiber- and Purkinje cell-, but not climbing fiber-, inputs, leading to changes in subthreshold processing that correlate with the level and direction of the conditioned eyelid movements. These changes appear sufficient, as optogenetic stimulation of the inputs evoke incremental eyelid closures over the course of conditioning. Our data reveal how electrophysiological and structural modifications at the level of synaptic inputs to cerebellar output neurons facilitate conditioning of eyelid movements.

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Action-based organization of a cerebellar module specialized for predictive control of multiple body parts

Cited by 25 publications

References 64 publications

A Systematic Review of Direct Outputs from the Cerebellum to the Brainstem and Diencephalon in Mammals

A Systematic Review of Direct Outputs from the Cerebellum to the Brainstem and Diencephalon in Mammals

Reward signals in the cerebellum: Origins, targets, and functional implications

Synaptic mechanisms for associative learning in the cerebellar nuclei

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