Action of intraduodenal ethanol on exocrine pancreatic secretion in chronic alcoholic rats fed with different diets

Dios, Isabel De; Gallego, H. A.; Manso, Manuel A.

doi:10.1016/0300-9629(94)90111-2

Cited by 3 publications

(1 citation statement)

References 39 publications

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“…Alcohol stimulates pancreatic secretion in some rodents [16][17][18]. After an intravenous ethanol injection (600 mg/kg), pancreatic secretion of lipase, chymotrypsin volume and bicarbonate was significantly decreased in non-alcoholic men but not in alcoholics [19].…”

Section: Introductionmentioning

confidence: 99%

Duodenal diazepam‐binding protein expression and plasma cholecystokinin after alcoholic pancreatitis

Pelli

Herzig

Uotila

et al. 2006

Scandinavian Journal of Clinical and Laboratory Investigation

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Section: Introductionmentioning

confidence: 99%

Duodenal diazepam‐binding protein expression and plasma cholecystokinin after alcoholic pancreatitis

Pelli

Herzig

Uotila

et al. 2006

Scandinavian Journal of Clinical and Laboratory Investigation

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Effects of ethanol and folic acid consumption during pregnancy and lactation on basal enzymatic secretion in the duodenal juice of offspring rats

et al. 2003

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A Review: Acute and Chronic Effects of Ethanol and Alcoholic Beverages on the Pancreatic Exocrine Secretion In Vivo and In Vitro

Niebergall-Roth

Harder

Singer

1998

Alcoholism Clin & Exp Res

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Whereas oral or intraduodenal ethanol causes a moderate stimulation of pancreatic bicarbonate and enzyme output, intravenous ethanol inhibits basal and hormonally stimulated pancreatic exocrine secretion in humans, dogs, cats, pigs, rabbits, and rats. This inhibition could be mediated by inhibitory cholinergic mechanisms or be the result of a direct cellular effect of ethanol. In vitro investigations have specified several signaling molecules that may be involved in the action of ethanol on stimulus-secretion coupling in the exocrine pancreas, including cyclic adenosine monophosphate, intracellular calcium, and cholecystokinin and somatostatin receptors. In difference to pure ethanol solutions and distilled spirits, beer strongly stimulates pancreatic enzyme output, probably by nonalcoholic fermentation products. During chronic alcoholism, the ethanol-induced inhibition is replaced by an enhanced enzyme output that causes intraductal protein precipitation. In vitro investigations suggest that this increase is reversible after alcohol withdrawal. The occurrence of protein precipitates is considered to be a crucial step in the development of chronic alcoholic pancreatitis in humans. Other ethanol-induced secretory alterations that may contribute to the development of alcoholic pancreatitis are a decreased secretion of trypsin inhibitor, an increased cholinergic tone, and changes in the concentration of lithostathine.

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Action of intraduodenal ethanol on exocrine pancreatic secretion in chronic alcoholic rats fed with different diets

Cited by 3 publications

References 39 publications

Duodenal diazepam‐binding protein expression and plasma cholecystokinin after alcoholic pancreatitis

Duodenal diazepam‐binding protein expression and plasma cholecystokinin after alcoholic pancreatitis

Effects of ethanol and folic acid consumption during pregnancy and lactation on basal enzymatic secretion in the duodenal juice of offspring rats

A Review: Acute and Chronic Effects of Ethanol and Alcoholic Beverages on the Pancreatic Exocrine Secretion In Vivo and In Vitro

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