Action of magnesium sulfate on platelet prostacyclin interaction and prostacyclin of blood vessels

Briel, R. C.; Lippert, T. H.; Zahradnik, H. P.

doi:10.1016/0002-9378(85)90124-3

Cited by 20 publications

(10 citation statements)

References 2 publications

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“…It was confirmed in subsequent studies from Germany and the U.S.A. that magnesium is necessary for the production of prostacyclin (Briel et a!., 1986(Briel et a!., , 1987Nadler eta!., 1987;Watson eta!., 1986). The paper by Nadlerfrom Los Angeles was based on urine analysis and therefore on whole body synthesis of prostacyclin following dosing of healthy men and women with magnesium: the levels of prostacyclin increased and blood pressure fell.…”

Section: How Does Magnesium Deficiency Cause Hypertension?mentioning

confidence: 57%

Magnesium and Other Nutrient Deficiencies as Possible Causes of Hypertension and Low Birthweight

Wynn¹,

Wynn²

1988

Nutr Health

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7.2 per cent of babies born in England and Wales in 1986 had birthweights below 2,500 g. Low birthweight and hypertension are associated. European trials have reported that oral supplementation with physiological amounts of magnesium during pregnancy reduces pregnancy hypertension and also miscarriage, preterm birth and fetal growth retardation. Magnesium deficiency causes hypertension and low birthweight in animals. In humans deficiency of thiamin and other B vitamins has also been reported to cause pregnancy hypertension and low birthweight. Magnesium and B vitamins are essential for the same biochemical reactions in energy metabolism. There is evidence that magnesium consumption of substantial numbers of women in Europe and North America is too low to support a healthy pregnancy. Magnesium and thiamin are lost in processing many foods. British trials of magnesium supplementation are advocated. It is suggested that more attention should be given to magnesium in nutritional advice.

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Section: How Does Magnesium Deficiency Cause Hypertension?mentioning

confidence: 57%

Magnesium and Other Nutrient Deficiencies as Possible Causes of Hypertension and Low Birthweight

Wynn¹,

Wynn²

1988

Nutr Health

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“…Plasma endothelin-1 levels are elevated in hypomagnesemic rats, and the levels are reduced in Mg-supplemented rats [43]. Increased extracellular Mg levels induce endothelial release of prostacyclin [44]. These findings suggest that a direct effect of Mg deficiency on vascular smooth muscle may be involved in the elevation of vascular tone [17] and that Mg supplementation may have the effect of lowering blood pressure.…”

Section: Discussionmentioning

confidence: 99%

Additional antihypertensive effect of magnesium supplementation with an angiotensin II receptor blocker in hypomagnesemic rats

Jin

Kim

et al. 2013

Korean J Intern Med

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Background/AimsMagnesium (Mg) is an essential element for vascular function and blood pressure regulation. Several studies have demonstrated that Mg concentration is inversely associated with blood pressure, and that Mg supplementation attenuates hypertension. The purpose of this study was to evaluate the effect of dietary Mg supplementation on the blood pressure effects of an angiotensin II receptor blocker (ARB) in hypomagnesemic rats.MethodsFifty male Sprague-Dawley rats were randomly divided into Mg-deficient (n = 30), normal diet plus Mg (n = 10), and control groups (n = 10). Mg-free, high-Mg, and normal-Mg diets were respectively fed to the rats. After 14 weeks, 10 of the 30 Mg-deficient rats were treated with Mg, 10 Mg-deficient rats received an ARB, and 10 Mg-deficient rats received an ARB plus Mg for 4 weeks.ResultsSystolic blood pressure was significantly higher in the Mg-deficient rats than in the control rats at week 14. Hypomagnesemic rats exhibited decreased systolic blood pressure after treatment with Mg, and systolic blood pressure showed a greater decrease after ARB treatment. Treatment with the ARB/Mg combination resulted in the greatest decrease in systolic blood pressure. Mg deficiency did not affect the serum angiotensin II level, but did increase the serum aldosterone concentration. Concomitant Mg/ARB supplementation significantly decreased the elevated serum aldosterone level in hypomagnesemic rats. Kidney tissues of the hypomagnesemic rats revealed mild to moderate inflammatory infiltrates. Mg and/or ARB treatment did not reverse the inflammatory reaction in the kidneys of hypomagnesemic rats.ConclusionsConcurrent dietary Mg supplementation can enhance ARB-induced blood pressure reduction in rats with hypomagnesemic hypertension.

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“…As for the effect of Mg on vascular endothelial cells, increased production of prostacyclin, a known potent antithrombotic substance, has already been reported. 27 Further studies will be required to determine the mechanism. On the other hand, additional dietary Mg decreased the plasma TG concentration that had been increased by the 1 % cholesterol diet.…”

Section: Discussionmentioning

confidence: 99%

Effect of dietary magnesium on development of atherosclerosis in cholesterol-fed rabbits.

et al. 1990

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The effect of dietary magnesium (Mg) on the development of atherosclerosis In cholesterol-fed rabbits was investigated. Male New Zealand White rabbits (n=31) were placed on five kinds of diets: regular, 1% cholesterol, and 1% cholesterol diets supplemented with either 300, 600, or 900 mg (as Mg) of Mg sulfate. The regular and 1% cholesterol diets contained 400 mg of Mg per 100 g. Each rabbit received 100 g daily of the appropriate diet Additional Mg was well tolerated and did not affect blood pressure or body weight The rabbits were sacrificed after 10 weeks, and the oil red O-posrave atherosclerotic area that covered the aortic Intima and the cholesterol content of the aorta was measured. Additional Mg decreased both the area of the aortic lesions and the cholesterol content of the aortas In a dose-dependent manner. The 1% cholesterol diet significantly Increased plasma cholesterol and triglycerlde concentrations and decreased high density llpoprotein (HDL) cholesterol concentration. Additional Mg had no further effect on cholesterol and HDL cholesterol concentrations, but it slightly decreased the rise In triglycerlde concentration. These results Indicate that dietary Mg prevents the development of atherosclerosis In cholesterol-fed rabbits by Inhibiting llpld accumulation In the aortic wall.

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Action of magnesium sulfate on platelet prostacyclin interaction and prostacyclin of blood vessels

Cited by 20 publications

References 2 publications

Magnesium and Other Nutrient Deficiencies as Possible Causes of Hypertension and Low Birthweight

Magnesium and Other Nutrient Deficiencies as Possible Causes of Hypertension and Low Birthweight

Additional antihypertensive effect of magnesium supplementation with an angiotensin II receptor blocker in hypomagnesemic rats

Effect of dietary magnesium on development of atherosclerosis in cholesterol-fed rabbits.

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