Action of the chemical agent fipronil on the reproductive process of semi-engorged females of the tick Rhipicephalus sanguineus (Latreille, 1806) (Acari: Ixodidae). Ultrastructural evaluation of ovary cells

Oliveira, Patrícia Rosa de; Bechara, Gervásio Henrique; Morales, Maria Aparecida Marin; Camargo‐Mathias, Maria Izabel

doi:10.1016/j.fct.2009.02.019

Cited by 71 publications

(65 citation statements)

References 19 publications

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“…Because of their exposure to the hemolymph, these cells may be collecting the toxic product and then transferring it to the interior of the oocyte. If so, it would be consistent with results obtained by Denardi et al (2004) and Oliveira et al (2009). In these studies, the exposure of R. sanguineus females to extracts of ''Neem'' leaves and fipronil was studied.…”

Section: Microscopy Research and Techniquesupporting

confidence: 62%

“…out of the cell (Oliveira et al, 2009). Thus, as the secondary compound circulated in the hemolymph, a fluid that also bathes the oocyte, it likely penetrated into the cell via the microvilli plasma membrane and lead to developmental inhibition and sometimes cell death.…”

Section: Microscopy Research and Techniquementioning

confidence: 97%

“…An ultrastructural study of the germ cells in R. sanguineus females has been previously done by Oliveira et al (2009). The results obtained from the females of the CG1 and CG2 control subgroups were the same as those in their study (Fig.…”

Section: Control Groupsmentioning

confidence: 98%

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Ultrastructural changes in the ovary cells of engorged Rhipicephalus sanguineus female ticks treated with esters of ricinoleic acid from castor oil (Ricinus communis)

Sampieri¹,

Arnosti²,

Nunes³

et al. 2011

Microscopy Res & Technique

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Rhipicephalus sanguineus is a widely distributed tick species that has adapted to the urban environment, and the dog is its main host. This species is also known as a vector and reservoir of diseases caused by bacteria, protozoa, and viruses. Currently, acaricides of synthetic chemical origin have been widely and indiscriminately used, leading to the development of resistance to these products by ticks and causing damage to the environment. Thus, these issues have made it necessary to seek other forms of controlling these ectoparasites. R. sanguineus was artificially infested in host New Zealand White rabbits, which were divided into four treatment groups: control (CG1 and CG2) and treatment (TG1 and TG2) groups. TG1 and TG2 hosts were provided with feed supplemented with esters of ricinoleic acid from castor oil at a concentration of 5 g/kg of feed for 7 and 15 days. Afterward, the ovaries of the female ticks were removed for analysis by transmission electron microscopy. The results showed ultrastructural changes in the somatic and germ cells of ovaries from TG1 and TG2 females, particularly with respect to chorion deposition, a protective membrane of the oocyte, as well as in the transport process of vitellogenic materials via the hemolymph and pedicel cells. Moreover, the mitochondria were less electron-dense and had cristae that were more disorganized than the mitochondria from CG1 and CG2 individuals. Thus, this study demonstrated the action of esters on the ovaries of R. sanguineus, signaling the prospect of a way to control this ectoparasite without affecting nontarget organisms or the environment.

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Section: Microscopy Research and Techniquesupporting

confidence: 62%

Section: Microscopy Research and Techniquementioning

confidence: 97%

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Ultrastructural changes in the ovary cells of engorged Rhipicephalus sanguineus female ticks treated with esters of ricinoleic acid from castor oil (Ricinus communis)

Sampieri¹,

Arnosti²,

Nunes³

et al. 2011

Microscopy Res & Technique

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“…, obtained by Oliveira et al (2009 ). Animals were given intraperitoneally a volume in the proportion of 10 mL of fipronil (30,50,or 100% of DL 50 ) per kilogram of body weight (0.2 mL).…”

mentioning

confidence: 96%

Action of the chemical agent fipronil (active ingredient of acaricide Frontline®) on the liver of mice: An ultrastructural analysis

Ferreira

Oliveira

Denardi

et al. 2011

Microscopy Res & Technique

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Fipronil, active ingredient of the acaricide Frontiline®, is a phenyl-pyrazolic derivative, and its efficacy in the elimination of several plagues, even in low concentrations, has already been demonstrated; however, its effect on nontarget organisms has not been thoroughly explained. In this sense, the objective of this study was to evaluate the effects of different dosages of fipronil on the liver of mice in artificial conditions. Results showed that the animals exposed to fipronil present significant ultrastrucutural changes in hepatic cells with evident cellular and cytoplasm disorganization in hepatocytes characterized by an increase in the number of organelles, mainly mitochondria and rough endoplasmic reticulum, organelles that, in the case of the exposed animals, were probably responsible for the enzymes' synthesis that have the function of inactivating the toxic metabolites. A fat accumulation in the hepatocytes' cytoplasm (steatosis) was observed, in addition to extended vacuolated areas, mainly in regions next to the cell nucleus. Alterations observed in the nuclei of the hepatocytes pointed out cell death processes. Moreover, Kupffer cells increased in number (hyperplasia) suggesting an increase in the phagocytic activity of the liver in the exposed animals.

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“…Orr et al (2009) chloride channels in insects (ZHAO et al, 2005). Also, it acts in the reproductive process by altering both the structure and function of germinative cells of R. sanguineus females (OLIVEIRA et al, 2009). Fipronil is used worldwide for the treatment and control of flea and tick infestations on cattle, cats and dogs (TAYLOR, 2001;GEORGE et al, 2004).…”

Section: Macdonald (1995)mentioning

confidence: 99%

Rhipicephalus(Boophilus) microplus resistant to acaricides and ivermectin in cattle farms of Mexico

Rodríguez-Vivas¹,

Pérez-Cogollo

Rosado-Aguilar

et al. 2014

Rev. Bras. Parasitol. Vet.

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Ticks and the diseases they transmit cause great economic losses to livestock in tropical countries. Non-chemical control alternatives include the use of resistant cattle breeds, biological control and vaccines. However, the most widely used method is the application of different chemical classes of acaricides and macrocyclic lactones. ResumoCarrapatos e as doenças por eles transmitidas causam grandes perdas econômicas ao gado dos países tropicais. Alternativas não-químicas incluem o uso de raças de gado que sejam resistentes, controle biológico e vacinas. No entanto, o método mais utilizado é a aplicação de diferentes classes químicas de acaricidas e lactonas macrocíclicas. Populações de piolhos de gado, Rhipicephalus (Boophilus) microplus, resistentes aos organofosfatos (OP), piretoides sintéticos (SP), amitraz e fipronil, foram descritas no México. Lactonas macrocíclicas são as drogas antiparasitárias mais vendidas no mercado veterinário mexicano. Populações de R. (B.) microplus resistentes à irvemectina foram relatadas no Brasil, Uruguai e especialmente no México (Veracruz e Yucatan). Embora os níveis de resistência à ivermectina no R. (B.) microplus do México tenha sido relativamente baixa, na maioria dos casos, algumas populações campestres de R. (B.) microplus mostraram altos níveis de resistência à ivermectina. A população CHPAT mostrou uma razão de resistência de 10,23 e 79,6 na concentração letal de 50% e 99%, respectivamente. Muitas populações campestres de R. (B.) microplus são resistentes a múltiplas classes de drogas antiparasitárias, incluindo organofosfatos (clorpirifós, coumafos e diazinon), piretoides (flumetrina, deltametrina e cipermetrina), amitraz e ivermectina. Este artigo relata o estado atual de resistência do R. (B.) microplus aos acaricidas, especialmente ivermectina, no gado mexicano.Palavras-chave: Rhipicephalus (B.) microplus, acaricida, resistência, lactona macrocíclica, controle de carrapatos.

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Action of the chemical agent fipronil on the reproductive process of semi-engorged females of the tick Rhipicephalus sanguineus (Latreille, 1806) (Acari: Ixodidae). Ultrastructural evaluation of ovary cells

Cited by 71 publications

References 19 publications

Ultrastructural changes in the ovary cells of engorged Rhipicephalus sanguineus female ticks treated with esters of ricinoleic acid from castor oil (Ricinus communis)

Ultrastructural changes in the ovary cells of engorged Rhipicephalus sanguineus female ticks treated with esters of ricinoleic acid from castor oil (Ricinus communis)

Action of the chemical agent fipronil (active ingredient of acaricide Frontline®) on the liver of mice: An ultrastructural analysis

Rhipicephalus(Boophilus) microplus resistant to acaricides and ivermectin in cattle farms of Mexico

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