Action of Various Metallic Chlorides on Calcaemia and Phosphataemia

Influence of Age on Experimental Cutaneous Calcification

“…In agreement with the macroscopic readings, the concentra tions of calcium and phosphorus found in the 28-day-old rats were significantly increased (P < 0.001) compared to normal concentra tions. In the 360-day-old animals, mineral contents found at PMX As expected [12,13], there was a significant increase (P < 0.001) of scrum calcium and phosphorus 1 and 3 h after lead acetate injection when compared with the means of control rats of the same age (group 1). The calcemia and phosphatcmia of 360-day-old rats increased significantly (P < 0 .001) only 1 h after treatment (group 2).…”

Relationship between iron, calcium and phosphate during experimental cutaneous calcinosis

“…At the same time, it shows that the elevation of both calcium and phosphorus is topographically related to the injected iron. It has been reported that in the rat the intravenous administration of several metallic chlorides (including FeCla) increases the level of blood calcium and phosphorus [7].…”

Time Course of Stomach Mineralization, Plasma, and Urinary Changes After a Single Intravenous Administration of Gadolinium(III) Chloride in the Male Rat

“…Further evidence for the production of insoluble colloids in the serum comes from our previous study, in which widespread uptake of deposits composed of Gd, calcium, and phosphate in the cells of the mononuclear phagocytic system was described (22 (24). There appears to be no role for parathyroid hormone or calcitonin in this effect: removal of these glands did not alter the ability of intravenously administered holmium chloride (another lanthanide chloride) to induce hypercalcemia and hyperphosphatemia (14), and calcitonin secretion did not alter following the hypercalcemia induced by intravenously administered lead acetate (20). In addition, in primary hyperparathyroidism the hypercalcemia is accompanied by normal or decreased plasma phosphate (5), whereas GdCl~ like other metalic chlorides induced both hypercalcemia and hyperphosphatemia (14,15,24 (21).…”

“…There appears to be no role for parathyroid hormone or calcitonin in this effect: removal of these glands did not alter the ability of intravenously administered holmium chloride (another lanthanide chloride) to induce hypercalcemia and hyperphosphatemia (14), and calcitonin secretion did not alter following the hypercalcemia induced by intravenously administered lead acetate (20). In addition, in primary hyperparathyroidism the hypercalcemia is accompanied by normal or decreased plasma phosphate (5), whereas GdCl~ like other metalic chlorides induced both hypercalcemia and hyperphosphatemia (14,15,24 (21). Recently, an additional histologic study of GdCl3-induced gastric mineralization in the rat was reported (11), and the authors speculated that mineralization occurred adjacent to parietal cells, due to local pertubation of the function of these cells in conjunction with elevated plasma calcium concentrations.…”