Action tremor in Parkinson's disease: frequency and relationship to motor and non‐motor signs

Gigante, Angelo Fabio; Bruno, Giorgia; Iliceto, Giovanni; Guido, Marco; Liuzzi, Daniele; Mancino, Paola; De, Maria Fara; Livrea, Paolo; Defazio, Giovanni

doi:10.1111/ene.12583

Cited by 36 publications

(31 citation statements)

References 39 publications

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“…We used the Mann–Whitney U ‐test to compare the clinical and demographic characteristics (age, age at disease onset, disease duration, dosage and duration of treatment, presence of dyskinesias, motor fluctuations, H&Y scores, MDS‐UPDRS scores and Non‐Motor Symptoms assessment scale for PD scores) of patients with and without RET off and on treatment. In accordance with previous studies , for the statistical analysis we used combined MDS‐UPDRS subscores to summarize the single item scores. The ‘bradykinesia subscore’ included four limbs and the global bradykinesia item scores, the ‘rigidity subscore’ included four limbs and neck item scores, and the ‘axial symptoms subscore’ included speech, facial expression, arising from chair, gait, posture and postural stability item scores.…”

Section: Methodsmentioning

confidence: 99%

Re‐emergent tremor in Parkinson's disease: the effect of dopaminergic treatment

Belvisi

Conte

Cutrona

et al. 2018

Euro J of Neurology

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Section: Methodsmentioning

confidence: 99%

Re‐emergent tremor in Parkinson's disease: the effect of dopaminergic treatment

Belvisi

Conte

Cutrona

et al. 2018

Euro J of Neurology

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“…Resting tremor is a well‐known feature of PS that also occurs in some ET‐plus cases . Action tremor, which is characteristic of ET, is also a feature of PD . Because of the overlapping tremor manifestations, clinical distinction between ET and PS can be difficult in some cases .…”

Section: Discussionmentioning

confidence: 99%

“…Resting tremor, which is characteristic of PD, may also occur during the late stages in some ET patients . Action tremor, which is the diagnostic feature of ET, is also present in some PD patients . Additionally, the clinical features of ET and PD each evolve over time .…”

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confidence: 99%

Parkinsonism in essential tremor cases: A clinicopathological study

Rajput

Bocking

et al. 2019

Movement Disorders

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Background Essential tremor and Parkinson's syndrome are two common movement disorders that may co‐occur in some individuals. There is no diagnostic neuropathology for essential tremor, but in PD and other Parkinson's syndrome variants, the neuropathology is well known. The spectrum of Parkinson's syndrome variants associated with essential tremor, their clinical features, and course have not been determined in autopsy‐confirmed cases. Objectives To identify: diagnostic features of essential tremor/Parkinson's syndrome, different Parkinson's syndrome variants, and long‐term clinical profile in such cases. Methods Patients that had an essential tremor diagnosis and a subsequent clinical or pathological diagnosis of Parkinson's syndrome seen in our clinic during 50 years were included. The diagnosis of parkinsonism was made when bradykinesia, rigidity, and resting tremor were all clinically evident. Results Twenty‐one cases were included. All the common variants of parkinsonism co‐occurred with essential tremor. The most common was PD (67%) followed by PSP. The pathological findings were not predicted clinically in 2 cases that had essential tremor/PD and in all 5 essential tremor/PSP cases. Conclusion In most essential tremor/Parkinson's syndrome patients, the main motor features of parkinsonism—bradykinesia, rigidity, and resting tremor—were identifiable. All known degenerative Parkinson's syndrome variants co‐occurred in essential tremor patients. © 2019 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.

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“…Rest tremor was noted at least during one evaluation among 47 pathologically verified Parkinsonian patients [5]. Action tremor was reported in 46–93% of PD patients depending on the selected populations [6, 7]. …”

Section: Tremor In Parkinson’s Diseasementioning

confidence: 99%

Rest tremor revisited: Parkinson’s disease and other disorders

Chen

Hopfner

Becktepe

et al. 2017

Transl Neurodegener

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Tremor is the most common movement disorder characterized by a rhythmical, involuntary oscillatory movement of a body part. Since distinct diseases can cause similar tremor manifestations and vice-versa, it is challenging to make an accurate diagnosis. This applies particularly for tremor at rest. This entity was only rarely studied in the past, although a multitude of clinical studies on prevalence and clinical features of tremor in Parkinson’s disease (PD), essential tremor and dystonia, have been carried out. Monosymptomatic rest tremor has been further separated from tremor-dominated PD. Rest tremor is also found in dystonic tremor, essential tremor with a rest component, Holmes tremor and a few even rarer conditions. Dopamine transporter imaging and several electrophysiological methods provide additional clues for tremor differential diagnosis. New evidence from neuroimaging and electrophysiological studies has broadened our knowledge on the pathophysiology of Parkinsonian and non-Parkinsonian tremor. Large cohort studies are warranted in future to explore the nature course and biological basis of tremor in common tremor related disorders.

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Action tremor in Parkinson's disease: frequency and relationship to motor and non‐motor signs

Cited by 36 publications

References 39 publications

Re‐emergent tremor in Parkinson's disease: the effect of dopaminergic treatment

Re‐emergent tremor in Parkinson's disease: the effect of dopaminergic treatment

Parkinsonism in essential tremor cases: A clinicopathological study

Rest tremor revisited: Parkinson’s disease and other disorders

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