Actions of Artemisia vulgaris extracts and isolated sesquiterpene lactones against receptors mediating contraction of guinea pig ileum and trachea

Natividad, Gaudencio M.; Broadley, Kenneth J.; Kariuki, Benson M.; Kidd, Emma Jane; Ford, William R.; Simons, Claire

doi:10.1016/j.jep.2011.06.042

Cited by 26 publications

(12 citation statements)

References 13 publications

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“…Finally, previous phytochemical study revealed that dichloromethane extract contains some sesquiterpene lactones and flavonoids (Ruiz-Cancino et al, 1993), which could be related to cholinergic receptor and/or Ca 2+ channel blockade showed by DEAl. Recently, yomogin, a sesquiterpene lactone and major component of Artemisia vulgaris, were identified to exhibit histamine H 1 receptor antagonism on gut and trachea, which suggest that this kind of compounds are responsible of the activity (Natividad et al, 2011). Further phytochemical and pharmacological studies are necessary for the isolation of bioactive compounds.…”

Section: Resultsmentioning

confidence: 99%

Relaxant effects of Artemisia ludoviciana on isolated rat smooth muscle tissues

Estrada‐Soto

Sánchez-Recillas

Navarrete‐Vázquez

et al. 2012

Journal of Ethnopharmacology

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Section: Resultsmentioning

confidence: 99%

Relaxant effects of Artemisia ludoviciana on isolated rat smooth muscle tissues

Estrada‐Soto

Sánchez-Recillas

Navarrete‐Vázquez

et al. 2012

Journal of Ethnopharmacology

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“…The team found that both extracts had an antagonistic effect on the H1 receptors and caused the relaxation of smooth muscles. Two main compounds were isolated from the chloroform fraction—yomogin and 1,2,3,4-diepoxy-11(13)-eudesmen-12,8-olide—of which the former showed significant antagonism toward the H1 receptor in the ileum [ 10 ].…”

Section: Biological Activities Of Extracts Confirmed By Scientifimentioning

confidence: 99%

“…For many centuries, this species has been mainly used for treating gynecological ailments and gastrointestinal diseases [ 3 , 4 , 5 , 6 , 7 ]. Recently, researches have proved that this species exhibits antioxidant, hypolipidemic, hepatoprotective, antispasmolytic, analgesic, estrogenic, cytotoxic, antibacterial, antifungal, hypotensive, and broncholytic effects [ 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

Significance of Artemisia Vulgaris L. (Common Mugwort) in the History of Medicine and Its Possible Contemporary Applications Substantiated by Phytochemical and Pharmacological Studies

et al. 2020

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Artemisia vulgaris L. (common mugwort) is a species with great importance in the history of medicine and was called the “mother of herbs” in the Middle Ages. It is a common herbaceous plant that exhibits high morphological and phytochemical variability depending on the location where it occurs. This species is well known almost all over the world. Its herb—Artemisiae vulgaris herba—is used as a raw material due to the presence of essential oil, flavonoids, and sesquiterpenoids lactones and their associated biological activities. The European Pharmacopoeia has listed this species as a potential homeopathic raw material. Moreover, this species has been used in traditional Chinese, Hindu, and European medicine to regulate the functioning of the gastrointestinal system and treat various gynecological diseases. The general aim of this review was to analyze the progress of phytochemical and pharmacological as well as professional scientific studies focusing on A. vulgaris. Thus far, numerous authors have confirmed the beneficial properties of A. vulgaris herb extracts, including their antioxidant, hepatoprotective, antispasmolytic, antinociceptive, estrogenic, cytotoxic, antibacterial, and antifungal effects. In addition, several works have reviewed the use of this species in the production of cosmetics and its role as a valuable spice in the food industry. Furthermore, biotechnological micropropagation of A. vulgaris has been analyzed.

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“…It is recommended to ingest 2-3 cups of decoctions A. vulgaris since it increases the blood flow in the pelvic region, this can lead to uterine contractions that can proceed to miscarriage. When administered in large quantities however, A. vulgaris is toxic and can cause epileptic episodes and bleeding problems because it also acts as an anticoagulant (Natividad et al, 2011). Prior antibacterial studies on A. vulgaris have revealed the potential of this plant.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Antibacterial Activity of Artemisia vulgaris Extracts

Addo-Mensah¹,

García²,

Maldonado³

et al. 2015

Research J. of Medicinal Plant

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Plants have been and still are the main source of a variety of drugs. Due to this trend, there is a need to investigate plants and determine if they possess any medicinal property. In this study, medicinal compounds in the stem, root and shoot of Artemisia vulgaris were extracted sequentially via Soxhlet extract using petroleum ether, acetone and 90% ethanol on water respectively. Antimicrobial activity of these extracts was tested against Staphylococcus aureus (SA), Methicillin Resistant Staphylococcus aureus (MRSA) and Bacillus subtilis (BS) using the disc diffusion method. Whereas acetone extract exhibited high antimicrobial activity (5 mg mLG against S. aureus and no activity against MRSA). Diminished or lack of antibacterial activity from the ethanol extract reported in this study conflicts previous studies which report higher antimicrobial activity in ethanolic extracts. Findings in this study therefore suggest that the active antimicrobial agents in A. vulgaris can be extracted better acetone than with ethanol.

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Actions of Artemisia vulgaris extracts and isolated sesquiterpene lactones against receptors mediating contraction of guinea pig ileum and trachea

Cited by 26 publications

References 13 publications

Relaxant effects of Artemisia ludoviciana on isolated rat smooth muscle tissues

Relaxant effects of Artemisia ludoviciana on isolated rat smooth muscle tissues

Significance of Artemisia Vulgaris L. (Common Mugwort) in the History of Medicine and Its Possible Contemporary Applications Substantiated by Phytochemical and Pharmacological Studies

Evaluation of Antibacterial Activity of Artemisia vulgaris Extracts

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