Actions of flavonoids and the novel anti-inflammatory flavone, hypolaetin-8-glucoside, on prostaglandin biosynthesis and inactivation

Alcaraz, Marı́a José; Hoult, J.R.S.

doi:10.1016/0006-2952(85)90529-5

Cited by 71 publications

(32 citation statements)

References 17 publications

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“…Also, this latex may contain chemical substances that can act to promote antiulcerogenic action ( Figure 5). Our preliminary phytochemical results indicated the presence of secondary metabolites (phenolic compounds/unsaponificable substances) in S. grantii that suggest that the antiulcerogenic effect of the latex in relation to the indomethacin and ethanol models, may be related to the presence of those substances in the appraised material (Alcaraz & Hoult, 1985;Aguwa, 1985;Bronner & Landry, 1985;Scarlat et al, 1985;Aguwa & Okunji, 1986;Beil et al, 1995;Matsuda et al, 1998;Araújo et al, 2002). However, it should be noted that the pure latex presented high values of CL50 when evaluated using the sharp toxicity with A. saline experiment and it presented biochemical alterations in relation to the ALT and AST parameters.…”

Section: Controlmentioning

confidence: 74%

Anti-ulcer activity of Synadenium grantii latex

Costa¹,

David²,

Pinto³

et al. 2012

Rev. bras. farmacogn.

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Synadenium grantii Hook f., Euphorbiaceae, is popularly known as leitosinha or janaúba. The diluted latex (18 drops/L of water) is commonly used in the south of Brazil to treat gastric disturbances. This study evaluated phytochemical screening and toxicity using Artemia salina Leach of crude bark extract and also latex. The toxicity and the anti-ulcer activity of S. grantii latex were also tested in rats. Phytochemical results showed presence of tannins, terpenes, unsaponificable substances, coumarins and anthraquinones in the crude bark extract and terpenes in the latex. Gas chromatography-mass spectrometry (GC-MS) analysis demonstrated the presence of diterpene tigliane esters in the latex, identified as 12-deoxyphorbol-13-(2-metilpropionate) and phorbol 12,13,20-triacetate. The toxicity results using A. salina presented CL50 26.58μg/mL and CL50 778.66μg/mL, for the latex and the crude bark extract respectively. The toxicological hepatic parameters of the diluted latex were not different to the control group (p<0.05). The eosinophils cells showed an increase in both the diluted and pure latex groups. The pure latex showed gastric protection of 90% (p<0.05) and the diluted latex showed 6% compared to the negative control. Therefore, our data indicate that S. grantii latex, under research conditions presented gastric protection. Pure latex showed more toxicity than the diluted latex.

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Section: Controlmentioning

confidence: 74%

Anti-ulcer activity of Synadenium grantii latex

Costa¹,

David²,

Pinto³

et al. 2012

Rev. bras. farmacogn.

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“…2) were reported to inhibit COX and 12-LOX from mouse epidermis, being more active on LOX (21). While some flavonoid glycosides including rutin and hypolaetin-8-glucoside rather enhanced COX activity from sheep seminal vesicle (22), certain flavonoids such as flavone, kaempferol, and quercetin were repeatedly found to be COX inhibitors from rat peritoneal macrophages (8). After these reports, many studies have been done to figure out the inhibitory activity of flavonoids on COX, mostly COX-1.…”

Section: Cellular Action Mechanismsmentioning

confidence: 99%

Anti-inflammatory Plant Flavonoids and Cellular Action Mechanisms

et al. 2004

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Abstract. Plant flavonoids show anti-inflammatory activity in vitro and in vivo. Although not fully understood, several action mechanisms are proposed to explain in vivo anti-inflammatory action. One of the important mechanisms is an inhibition of eicosanoid generating enzymes including phospholipase A 2 , cyclooxygenases, and lipoxygenases, thereby reducing the concentrations of prostanoids and leukotrienes. Recent studies have also shown that certain flavonoids, especially flavone derivatives, express their anti-inflammatory activity at least in part by modulation of proinflammatory gene expression such as cyclooxygenase-2, inducible nitric oxide synthase, and several pivotal cytokines. Due to these unique action mechanisms and significant in vivo activity, flavonoids are considered to be reasonable candidates for new anti-inflammatory drugs. To clearly establish the therapeutic value in inflammatory disorders, in vivo anti-inflammatory activity, and action mechanism of varieties of flavonoids need to be further elucidated. This review summarizes the effect of flavonoids on eicosanoid and nitric oxide generating enzymes and the effect on expression of proinflammatory genes. In vivo anti-inflammatory activity is also discussed. As natural modulators of proinflammatory gene expression, certain flavonoids have a potential for new anti-inflammatory agents.

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“…Flavonoids have many biologic effects on protein synthesis, cell differentiation, and angiogenesis in human (37). Besides, various types of flavonoids, both glycoside and non-glycoside types, have been reported to have anti-inflammatory and analgesic effects (37)(38)(39).…”

Section: Discussionmentioning

confidence: 99%

In Vivo Antinociceptive Effects of Persian Shallot (Allium hirtifolium) in Male Rat

Mohammadi¹,

Mahmoodi²,

Zarei³

et al. 2015

Avicenna J Neuro Psych Physio

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Background:The tendency toward using herbal plants instead of synthetic drugs is increasing in recent years because of their lower adverse effects and high varieties of efficient components. Objectives: In this investigation, analgesic effects of hydroalcoholic leaf extract of Allium hirtifolium were studied in male rats. Materials and Methods: A total of 48 adult male rats were divided eight groups: control, intraperitoneal 50, 100, and 200 mg/kg of extract, 200 mg/kg of A. hirtifolium extract plus aspirin, aspirin (1 mg/kg), morphine (1 mg/kg), and 200 mg/kg of A. hirtifolium extract plus naloxone (1 mg/kg). The analgesic effects of A. hirtifolium were assessed with writhing, tail-flick, and formalin tests. The data were compared with control by one-way ANOVA and Tukey post hoc test. Results: Allium hirtifolium extract at (200 mg/kg dosage), alone and in combination with aspirin, had shown antinociceptive effect in writhing, tail-flick, and formalin tests (P < 0.01). Allium hirtifolium extract (at 100 mg/kg dosage) had just shown analgesic effects on tailflick and formalin (chronic phase) tests. Conclusions: It looks that A. hirtifolium has antinociceptive effects that might be due to flavonoids and saponins in plant the analgesic effect of which was demonstrated previously.

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Actions of flavonoids and the novel anti-inflammatory flavone, hypolaetin-8-glucoside, on prostaglandin biosynthesis and inactivation

Cited by 71 publications

References 17 publications

Anti-ulcer activity of Synadenium grantii latex

Anti-ulcer activity of Synadenium grantii latex

Anti-inflammatory Plant Flavonoids and Cellular Action Mechanisms

In Vivo Antinociceptive Effects of Persian Shallot (Allium hirtifolium) in Male Rat

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