Anti-inflammatory Plant Flavonoids and Cellular Action Mechanisms

Kim, Hyun Pyo; Son, Kun Ho; Chang, Hyeun Wook; Kang, Sam Sik

doi:10.1254/jphs.crj04003x

Cited by 849 publications

(535 citation statements)

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“…Flavonoids are widely distributed in the plant kingdom and more than 4000 derivatives have been identified [97]. Besides anticancer, antiviral, antimicrobial, immunmodulatory and antithrombotic activities, the anti-inflammatory properties, observed in vitro and in vivo, are most recognized.…”

Section: Inhibitors Of 5-lo Product Synthesis From Plant Originmentioning

confidence: 99%

“…Thus, flavonoids have been shown to inhibit acute or chronic inflammation in various animal models such as rat Freund's adjuvant arthritis [98], [99] and carrageenan-induced mouse paw edema, when given orally [99], [100]. In particular, however, flavonoids showed beneficial effects in AA-induced ear edema, when applied topically (for review see [97]). The reduction of reactive oxygen species and the suppression of eicosanoid biosynthesis due to interference with PLA 2 , COX and LO enzymes may be the major underlying molecular mechanisms.…”

Section: Inhibitors Of 5-lo Product Synthesis From Plant Originmentioning

confidence: 99%

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Inhibition of 5-Lipoxygenase Product Synthesis by Natural Compounds of Plant Origin

Werz¹

2007

Planta Med

155

135

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The biosynthesis of leukotrienes (LTs) is initiated by the transformation of free arachidonic acid to LTA 4 by 5-lipoxygenase (5-LO). Subsequent enzymatic conversion of LTA 4 yields LTB 4 and the cysteinyl-LTs C 4 , D 4 and E 4 . LTs have prominent functions in pathophysiology and are connected to numerous disorders including bronchial asthma, allergic rhinitis, inflammatory bowel and skin diseases, rheumatoid arthritis, cancer, osteoporosis and cardiovascular diseases. Pharmacological and genetic interruption of the 5-LO pathway or blockade of LT receptors, serving as means for intervention with LTs, may be of therapeutic value for certain related disorders. Natural or plant-derived substances were among the first 5-LO inhibitors identified in the early 1980 s. To date, a huge number of diverse plant-derived compounds have been reported to interfere with 5-LO product synthesis. However, many investigations have addressed the efficacy of a given compound solely in cellular test systems and analysis of direct interference with 5-LO has been neglected. In the first part of this review, the biology and molecular pharmacology of the 5-LO pathway is summarized in order to understand its overall regulation and complexity as well as to comprehend the possible points of attack of compounds that eventually lead to inhibition of 5-LO product formation in intact cells. In the second part, natural compounds that interfere with 5-LO product formation are compiled and grouped into structural classes, and the underlying molecular mechanisms and structureactivity relationships are discussed.

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Section: Inhibitors Of 5-lo Product Synthesis From Plant Originmentioning

confidence: 99%

Section: Inhibitors Of 5-lo Product Synthesis From Plant Originmentioning

confidence: 99%

Inhibition of 5-Lipoxygenase Product Synthesis by Natural Compounds of Plant Origin

Werz¹

2007

Planta Med

155

135

View full text Add to dashboard Cite

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“…In addition, the plants of "Phytovenol" capsules contain vitamins, macroand trace elements, fatty oils and protein substances. Hence, ensuring the antioxidant, hypolipid and hepatoprotective activity of the examined medicine [3,4].…”

Section: Discussionmentioning

confidence: 99%

Investigation of the hepatoprotective properties of “Phytovenol” capsules on the model of medicamentous hepatitis in rats

Gerush

Lenytska

Yakovleva

et al. 2014

Current Issues in Pharmacy and Medical Sciences

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This scientific paper is an investigation of the pharmacological activity of the new medical preparation "Phytovenol" (capsules in the dose of 150 mg/kg) on the pattern of hepatitis in rats induced by paracetamol administration. The authors of the article, for the first time under experimental conditions, detected a hepatoprotective effect that was brought about by "Phytovenol" capsule administration. This is realized due to the antioxidant, antitoxic and anticytolytic activity of the examined medicine. The study found that its efficacy is not lower than the classical hepatoprotector -"Silibor" tablets. The results obtained suggest that it is possible to extend the range of available hepatoprotectors and improve the quality of treatment for liver diseases, by introducing "Phytovenol" capsules into medical practice.

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“…the whole cell binding assay was used to study the binding parameters of estrogen binding sites in B-1F cells as previously published (1)…”

Section: Methodsmentioning

confidence: 99%

“…A traditional chinese medicine is composed of many components (herbs) and shows various pharmacological actions, mechanisms of which are not fully understood. Also many herbs contained flavonoids which are known to have anti-inflammatory, antioxidant, antibacterial, antiviral and antitumor activities (1)(2)(3)(4)(5). therefore, anti-carcinogenic action and induction of apoptosis by herbs and their constituents are interesting topics of research.…”

Section: Introductionmentioning

confidence: 99%

Possible mechanism of growth inhibition by Scutellaria baicalensis in an estrogen-responsive mouse tumor cell line

Murashima

Katayama²,

Shojiro³

et al. 2011

Oncol Rep

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Abstract.We have studied the effects of saiboku-to, a traditional chinese medicine having suppressive activities for leukotriene production and release, on the proliferation of the estrogen-responsive mouse leydig tumor cell line B-1F. In our previous reports, it is shown that saiboku-to promotes, but Scutellaria baicalensis, one of the components (herbs) of Saiboku-to, significantly inhibits the proliferation of B-1F cells in vitro and in vivo, and induces DnA fragmentation and morphological changes such as nuclear aggregation and fragmentation. In this study, we examined telomerase activity, cell cycle, polyunsaturated fatty acid metabolism and expression of nuclear factor κB (nF-κB) in order to determine the mechanism of growth inhibition in B-1F cells treated with Scutellaria baicalensis. telomerase activity was decreased in a dose-dependent manner in treated B-1F cells. cellular populations in the sub-g0/g1 and g2/M phases were increased, but those in M phase had no change. Although cyclin D1 mrnA was highly expressed in the presence of estradiol (e2), cyclin A and E mRNA levels did not significantly change. When B-1F cells were treated with Scutellaria baicalensis, expression of cyclin D1 was suppressed and that of p21 was inversely increased. Moreover, Scutellaria baicalensis influenced arachidonic and linoleic acid metabolism, and increased production of 13(s)-HoDe. In the presence of e2 Scutellaria baicalensis decreased expression of nF-κB p65 to 0.71-fold in B-1F cells. these results show that Scutellaria baicalensis might induce cell cycle arrest at g1 phase and apoptosis via inhibition of telomerase activity, changes of enzymatic activities in polyunsaturated fatty acid metabolism and suppression of nF-κB.

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Anti-inflammatory Plant Flavonoids and Cellular Action Mechanisms

Cited by 849 publications

References 95 publications

Inhibition of 5-Lipoxygenase Product Synthesis by Natural Compounds of Plant Origin

Inhibition of 5-Lipoxygenase Product Synthesis by Natural Compounds of Plant Origin

Investigation of the hepatoprotective properties of “Phytovenol” capsules on the model of medicamentous hepatitis in rats

Possible mechanism of growth inhibition by Scutellaria baicalensis in an estrogen-responsive mouse tumor cell line

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