Actions of PACAP and VIP on melanotrope cells of Xenopus laevis

Kidane, Adhanet H.; Cruijsen, Peter M. J. M.; Bazán, María Ángeles Ortiz; Vaudry, Hubert; Leprince, Jérôme; Kuijpers-Kwant, Frouwke J.; Roubos, Eric W.; Jenks, Bruce G.

doi:10.1016/j.peptides.2007.03.013

Cited by 8 publications

(12 citation statements)

References 37 publications

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“…Indeed, the occurrence of PACAP mRNA in the neurointermediate lobe of rat (Tanaka et al, 1997b), frog (Alexandre et al, 2000b), and PAC1-R mRNA in the rat pars intermedia (Shioda et al, 1997a) strongly suggests that PACAP can act as a paracrine regulator of melanotrope cell activity. In agreement with this hypothesis, it has been shown that PACAP-LI in the neural lobe increases when frogs are placed on a white background and that PACAP, acting through VPAC1-R, induces the release of BDNF, which in turn stimulates POMC biosynthesis and MSH secretion (Kidane et al, 2007(Kidane et al, , 2008). …”

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confidence: 70%

“…The stimulatory effect of PACAP on POMC gene expression and ␣-MSH secretion is associated with calcium influx through L-type calcium channels (Tanaka et al, 1997b). In the frog X. laevis, PACAP stimulates POMC gene expression in tissue culture of neurointermediate lobes and triggers the secretory activity of perifused isolated melanotrope cells (Kidane et al, 2007(Kidane et al, , 2008. Moreover, PACAP-LI in the neural lobe of X. laevis is higher when the animals are placed on an illuminated white environment, indicating that the peptide plays a physiological role in the neuroendocrine control of melanotrope cells during background color adaptation (Kidane et al, 2007(Kidane et al, , 2008.…”

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confidence: 99%

“…In the frog X. laevis, PACAP stimulates POMC gene expression in tissue culture of neurointermediate lobes and triggers the secretory activity of perifused isolated melanotrope cells (Kidane et al, 2007(Kidane et al, , 2008. Moreover, PACAP-LI in the neural lobe of X. laevis is higher when the animals are placed on an illuminated white environment, indicating that the peptide plays a physiological role in the neuroendocrine control of melanotrope cells during background color adaptation (Kidane et al, 2007(Kidane et al, , 2008. Indeed, the occurrence of PACAP mRNA in the neurointermediate lobe of rat (Tanaka et al, 1997b), frog (Alexandre et al, 2000b), and PAC1-R mRNA in the rat pars intermedia (Shioda et al, 1997a) strongly suggests that PACAP can act as a paracrine regulator of melanotrope cell activity.…”

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confidence: 99%

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Pituitary Adenylate Cyclase-Activating Polypeptide and Its Receptors: 20 Years after the Discovery

et al. 2009

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Pituitary Adenylate Cyclase-Activating Polypeptide and Its Receptors: 20 Years after the Discovery

et al. 2009

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“…Several studies have provided evidence that not only the structure, but the functions of PACAP have also been conserved. Among others, PACAP stimulates TSH release from the bullfrog pituitary (Okada et al 2007), regulates melanotrope cell activity in Xenopus (Kidane et al 2007), influences gonadotrophin secretion in goldfish pituitary cells (Sawisky and Chang 2005), affects food intake in chick and goldfish (Jozsa et al 2006;Matsuda et al 2006;Matsuda and Maruyama 2007), has muscle relaxant activity in fish (Matsuda et al 2000), enhances memory functions and is involved in rhythmical functions in chicken (Jozsa et al 2005;Nagy and Csernus 2007) and regulates neuronal development in zebrafish (Wu et al 2006).…”

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confidence: 99%

PACAP Has Anti-apoptotic Effect in the Salivary Gland of an Invertebrate Species, Helix pomatia

et al. 2008

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Pituitary adenylate cyclase activating polypeptide (PACAP) shows a remarkable sequence similarity among species and several studies provide evidence that the functions of PACAP have also been conserved among vertebrate species. Relatively little is known about its presence and functions in invertebrates. The aim of the present study was to investigate whether the well-known anti-apoptotic effect of PACAP can also be demonstrated in invertebrates. This effect was studied in the salivary gland of a molluscan species, Helix pomatia. In this work, we first showed the presence of PACAP-like immunoreactivity in the Helix salivary gland by means of immunohistochemistry. Radioimmunoassay measurements showed that PACAP38-like immunoreactivity dominated in the salivary gland of both active and inactive snails and its concentration was higher in active than in inactive animals in contrast to PACAP27-like immunoreactivity, which did not show activity-dependent changes. PACAP induced a significant elevation of cAMP level in salivary gland extracts. Application of apoptosis-inducing agents, dopamine and colchicine, led to a marked increase in the number of terminal uridine deoxynucleotidyl transferase dUTP nick end labeling (TUNEL)-positive apoptotic cells in the salivary gland, which was significantly attenuated by PACAP treatment. In a similar manner, the number of caspase-positive cells was reduced after co-application of dopamine and PACAP. Taken together, the data indicate that PACAP activates cAMP in a molluscan species and we show, for the first time, that PACAP is anti-apoptotic in the invertebrate Helix pomatia.

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“…PACAP in the CNS modifies amphibian, Xenopus laevis, skin melanophore cell activity and stimulates pituitary proopiomelanocortin (POMC) biosynthesis and α-MSH (melanocyte-stimulating hormone) release that activates the melanocortin receptors (MCs), which stimulate a cAMP dependent mechanism (Kidane et al, 2007;Koch and Lutz-Bucher, 1992;Rene et al, 1996). PACAP also has a direct action on amphibian skin and provokes melanin pigment granule dispersal via activation of a specific endogenous VPAC2 receptor (Marotti et al, 1999;Pereira et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

PACAP system evolution and its role in melanophore function in teleost fish skin

Cardoso

Félix

Martins

et al. 2015

Molecular and Cellular Endocrinology

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Pituitary adenylate cyclase-activating polypeptide (PACAP) administered to tilapia melanophores ex-vivo causes significant pigment aggregation and this is a newly identified function for this peptide in fish. The G-protein coupled receptors (GPCRs), adcyap1r1a (encoding Pac1a) and vipr2a (encoding Vpac2a), are the only receptors in melanophores with appreciable levels of expression and are significantly (p < 0.05) down-regulated in the absence of light. Vpac2a is activated exclusively by peptide histidine isoleucine (PHI), which suggests that Pac1a mediates the melanin aggregating effect of PACAP on melanophores. Paradoxically activation of Pac1a with PACAP caused a rise in cAMP, which in fish melanophores is associated with melanin dispersion. We hypothesise that the duplicate adcyap1ra and vipr2a genes in teleosts have acquired a specific role in skin and that the melanin aggregating effect of PACAP results from the interaction of Pac1a with Ramp that attenuates cAMP-dependent PKA activity and favours the Ca(2+)/Calmodulin dependent pathway.

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Actions of PACAP and VIP on melanotrope cells of Xenopus laevis

Cited by 8 publications

References 37 publications

Pituitary Adenylate Cyclase-Activating Polypeptide and Its Receptors: 20 Years after the Discovery

Pituitary Adenylate Cyclase-Activating Polypeptide and Its Receptors: 20 Years after the Discovery

PACAP Has Anti-apoptotic Effect in the Salivary Gland of an Invertebrate Species, Helix pomatia

PACAP system evolution and its role in melanophore function in teleost fish skin

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