Actions of pure bradykinin

An Effect of Histamine on the Nictitating Membrane of the Cat: Potentiation of the Actions of Adrenaline, Noradrenaline and Acetylcholine*

“…Also consistent with a potentiation mechanism involving vasodilatation within the nictitating membrane are the findings that under experimental conditions identical to those employed for histamine, other vasodilators also produced potentiation, whereas vasoconstrictors produced inhibition. Among the vasodilators tested, bradykinin, the one most closely comparable in vasodilating potency to histamine in other experimental situations (Elliott, Horton & Lewis, 1960), was the only one which approached histamine in efficacy. In this connexion it also may be pertinent that of the vasodilators studied only bradykinin further resembles histamine in its ability to increase capillary permeability.…”

Observations on an Isolated, Innervated Preparation of Rat Urinary Bladder

“…However, the response to bradykinin occurred only after a latent period and developed slowly. The effects of bradykinin on the bladder had the characteristics of its effects on some other smooth muscles (Elliott, Horton & Lewis, 1960;Konzett & Sturmer, 1960). It seems unlikely that bradykinin mediates the responses of the bladder to nerve stimulation.…”

INHIBITION OF PLASMA KININASE ACTIVITY AT SLIGHTLY ACID pH

“…The plasma kinin bradykinin is a most potent vasodilator, and in higher concentrations also reproduces the other cardinal signs of the inflammatory responseincreased capillary permeability, pain and accumulation and migration of leucocytes (Elliott, Horton & Lewis, 1960;Lewis, 1962a).…”