Actions of vitamins A and E and some nicotinic acid derivatives on plasma lipids and on lipid infiltration of aorta in cholesterol-fed rabbits

Brattsand, Ralph

doi:10.1016/0021-9150(75)90067-2

Cited by 36 publications

(5 citation statements)

References 27 publications

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“…Tocopherols have been shown to inhibit atherogenesis in rabbits 6,7 and monkeys 8 . Antioxidants, in general, are considered to have anti‐atherosclerotic properties.…”

Section: General Chemical Characteristics Of Red Palm Oilmentioning

confidence: 99%

Red palm oil in experimental atherosclerosis

Kritchevsky

Tepper

Czarnecki

et al. 2002

Asia Pac J Clin Nutr

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“…Tocopherols have been shown to inhibit atherogenesis in rabbits 6,7 and monkeys 8 . Antioxidants, in general, are considered to have anti‐atherosclerotic properties.…”

Section: General Chemical Characteristics Of Red Palm Oilmentioning

confidence: 99%

Red palm oil in experimental atherosclerosis

Kritchevsky

Tepper

Czarnecki

et al. 2002

Asia Pac J Clin Nutr

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“…[21][22][23][24] Human and animal studies have examined the effects of α-Toc on plasma lipids with mixed results. In animal models, α-Toc supplementation is generally hypocholesterolemic [25][26][27][28][29][30] whereas, in most human trials, α-Toc has typically shown no effect on plasma cholesterol concentrations except for certain circumstances such as in diabetes. 31 The cholesterol-lowering mechanisms of Se and α-Toc are not well understood.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant Supplements Improve Profiles of Hepatic Oxysterols and Plasma Lipids in Butter-fed Hamsters

Poirier

Cockell

Ratnayake

et al. 2010

Nutr Metab Insights

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Hypercholesterolemic diets are associated with oxidative stress that may contribute to hypercholesterolemia by adversely affecting enzymatically-generated oxysterols involved in cholesterol homeostasis. An experiment was conducted to examine whether the cholesterol-lowering effects of the antioxidants selenium and α-tocopherol were related to hepatic oxysterol concentrations. Four groups of male Syrian hamsters (n = 7–8) were fed high cholesterol and saturated fat (0.46% cholesterol, 14.3% fat) hypercholesterolemic semi-purified diets: 1) Control; 2) Control + α-tocopherol (67 IU all-racemic-α-tocopheryl-acetate/kg diet); 3) Control + selenium (3.4 mg selenate/kg diet); and 4) Control + α-tocopherol + selenium. Antioxidant supplementation was associated with lowered plasma cholesterol concentrations, decreased tissue lipid peroxidation and higher hepatic oxysterol concentrations. A second experiment examined the effect of graded selenium doses (0.15, 0.85, 1.7 and 3.4 mg selenate/kg diet) on mRNA expression of the oxysterol-generating enzyme, hepatic 27-hydroxylase (CYP27A1, EC 1.14.13.15), in hamsters (n = 8–9) fed the hypercholesterolemic diets. Supplementation of selenium at 3.4 mg selenate/kg diet was not associated with increased hepatic 27-hydroxylase mRNA. In conclusion, the cholesterol lowering effects of selenium and α-tocopherol were associated with increased hepatic enzymatically generated oxysterol concentrations, which appears to be mediated via improved antioxidant status rather than increased enzymatic production.

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“…Tocopherols have been reported to inhibit atherosclerosis in rabbits [15,16] and in monkeys [17]. Antioxidants have been shown to reduce the risk of atherosclerosis in human populations [18,19].…”

Section: Introductionmentioning

confidence: 99%