Different palm oil preparations reduce plasma cholesterol concentrations and aortic cholesterol accumulation compared to coconut oil in hypercholesterolemic hamsters

Wilson, Thomas A.; Nicolosi, Robert J.; Kotyla, Timothy; Sundram, Kalyana; Kritchevsky, David

doi:10.1016/j.jnutbio.2005.03.007

Cited by 31 publications

(37 citation statements)

References 40 publications

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“…In phase 2, switching the SFA source from palm to coconut oil resulted in a marked increase in plasma non-HDL cholesterol and triglyceride concentrations. This is consistent with previous reports where feeding 12:0114:0 (coconut oil) has been shown to elicit a greater hyperlipidemic response than 16:0 (palm oil) in the hamster model (31). The response has been attributed to the higher content of oleic and linoleic acids in palm than in coconut oil.…”

Section: Discussionsupporting

confidence: 93%

Effects of Dietary Palmitoleic Acid on Plasma Lipoprotein Profile and Aortic Cholesterol Accumulation Are Similar to Those of Other Unsaturated Fatty Acids in the F1B Golden Syrian Hamster

Matthan

Dillard

Lecker

et al. 2009

The Journal of Nutrition

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The lower susceptibility of palmitoleic acid (16:1) to oxidation compared to PUFA may confer functional advantages with respect to finding acceptable alternatives to partially hydrogenated fats, but limited data are available on its effect on cardiovascular risk factors. This study investigated the effect of diets (10% fat, 0.1% cholesterol, wt:wt) enriched with macadamia [monounsaturated fatty acid (MUFA)16:1], palm (SFA,16:0), canola (MUFA,18:1), or safflower (PUFA,18:2) oils on lipoprotein profiles and aortic cholesterol accumulation in F1B Golden Syrian hamsters (n = 16/group). After 12 wk, 8 hamsters in each group were killed (phase 1). The remaining hamsters fed palm oil were changed to a diet containing coconut oil, while hamsters in the other diet groups continued on their original diets for an additional 6 wk (phase 2). With minor exceptions, the time course and dietary SFA source did not alter the study outcomes. Macadamia oil-fed hamsters had lower non-HDL cholesterol and triglyceride concentrations compared with the palm and coconut oil-fed hamsters and higher HDL-cholesterol compared with the coconut, canola, and safflower oil-fed hamsters. The aortic cholesterol concentration was not affected by dietary fat type. The hepatic cholesterol concentration was higher in the unsaturated compared with the saturated oil-fed hamsters. RBC membrane and aortic cholesteryl ester, triglyceride, and phospholipid fatty acid profiles reflected that of the dietary oil. These data suggest that an oil relatively high in palmitoleic acid does not adversely affect plasma lipoprotein profiles or aortic cholesterol accumulation and was similar to other unsaturated fatty acid-rich oils.

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Section: Discussionsupporting

confidence: 93%

Effects of Dietary Palmitoleic Acid on Plasma Lipoprotein Profile and Aortic Cholesterol Accumulation Are Similar to Those of Other Unsaturated Fatty Acids in the F1B Golden Syrian Hamster

Matthan

Dillard

Lecker

et al. 2009

The Journal of Nutrition

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“…Wilson et al 33 investigated the influence on hamsters fed RPO or RBO-PO or RBO-PO plus an RPO extract on plasma cholesterol levels and aortic accumulation versus hamsters fed on coconut oil. Their findings showed that plasma total cholesterol and non-HDL-cholesterol (non-HDL-C) were significantly lower in the hamsters fed RPO compared to coconut oil-fed hamsters.…”

Section: Role In Atherosclerosismentioning

confidence: 99%

Red palm oil: nutritional, physiological and therapeutic roles in improving human wellbeing and quality of life

Oguntibeju

Esterhuyse

Truter

2009

British Journal of Biomedical Science

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The link between dietary fats and cardiovascular disease has created a growing interest in dietary red palm oil research. Also, the link between nutrition and health, oxidative stress and the severity or progression of disease has stimulated further interest in the potential role of red palm oil (a natural antioxidant product) to improve oxidative status by reducing oxidative stress in patients with cardiovascular disease, cancer and other chronic diseases. In spite of its level of saturated fatty acid content (50%), red palm oil has not been found to promote atherosclerosis and/or arterial thrombosis. This is probably due to the ratio of its saturated fatty acid to unsaturated fatty acid content and its high concentration of antioxidants such as beta-carotene, tocotrienols, tocopherols and vitamin E. It has also been reported that the consumption of red palm oil reduces the level of endogenous cholesterol, and this seems to be due to the presence of the tocotrienols and the peculiar isomeric position of its fatty acids. The benefits of red palm oil to health include a reduction in the risk of arterial thrombosis and/or atherosclerosis, inhibition of endogenous cholesterol biosynthesis, platelet aggregation, a reduction in oxidative stress and a reduction in blood pressure. It has also been shown that dietary red palm oil, taken in moderation in animals and humans, promotes the efficient utilisation of nutrients, activates hepatic drug metabolising enzymes, facilitates the haemoglobinisation of red blood cells and improves immune function. This review provides a comprehensive overview of the nutritional, physiological and biochemical roles of red palm oil in improving wellbeing and quality of life.

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“…PO and PKO should be classified as cholesterol-raising fats for humans [12]. In contrast, it was found that feeding rats or hamsters on diets that contained more than 10% PO for 3 weeks or more improved serum and liver lipid profiles and enhanced HDL-C [13][14][15][16][17][18]. They recommended that it could be useful for preventing cardiovascular disease.…”

Section: Introductionmentioning

confidence: 99%

Palm kernel oil increases the risk of coronary heart disease in rats compared with ghee

Khairy¹,

Morsi²,

Galal³

et al. 2014

IOSRJPBS

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Different palm oil preparations reduce plasma cholesterol concentrations and aortic cholesterol accumulation compared to coconut oil in hypercholesterolemic hamsters

Cited by 31 publications

References 40 publications

Effects of Dietary Palmitoleic Acid on Plasma Lipoprotein Profile and Aortic Cholesterol Accumulation Are Similar to Those of Other Unsaturated Fatty Acids in the F1B Golden Syrian Hamster

Effects of Dietary Palmitoleic Acid on Plasma Lipoprotein Profile and Aortic Cholesterol Accumulation Are Similar to Those of Other Unsaturated Fatty Acids in the F1B Golden Syrian Hamster

Red palm oil: nutritional, physiological and therapeutic roles in improving human wellbeing and quality of life

Palm kernel oil increases the risk of coronary heart disease in rats compared with ghee

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