Activatable near infrared dye conjugated hyaluronic acid based nanoparticles as a targeted theranostic agent for enhanced fluorescence/CT/photoacoustic imaging guided photothermal therapy

Liang, Xiaolong; Lei, Fang; Li, Xiaoda; Zhang, Xu; Wang, Fan

doi:10.1016/j.biomaterials.2017.04.006

Cited by 111 publications

(61 citation statements)

References 76 publications

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“…NIR dye-conjugated HA NPs (from HA with M W 32kDa) and an encapsulation of perfluorooctylbromide NPs were synthesized for enhanced PTT. These nanoparticles had hydrodynamic diameters of 100 ± 10.7 nm, and selectively targeted CD44-over-expressing HT-29 human colon cancer cells both in in vitro and in vivo models [92].…”

Section: Applications Of Ha-based Nanoparticlesmentioning

confidence: 99%

Hyaluronan-Based Nanofibers: Fabrication, Characterization and Application

et al. 2019

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Nano- and microfibers based on biopolymers are some of the most attractive issues of biotechnology due to their unique properties and effectiveness. Hyaluronan is well-known as a biodegradable, naturally-occurring polymer, which has great potential for being utilized in a fibrous form. The obtaining of fibers from hyaluronan presents a major challenge because of the hydrophilic character of the polymer and the high viscosity level of its solutions. Electrospinning, as the advanced and effective method of the fiber generation, is difficult. The nano- and microfibers from hyaluronan may be obtained by utilizing special techniques, including binary/ternary solvent systems and several polymers described as modifying (or carrying), such as polyethylene oxide (PEO) and polyvinyl alcohol (PVA). This paper reviews various methods for the synthesis of hyaluronan-based fibers, and also collects brief information on the properties and biological activity of hyaluronan and fibrous materials based on it.

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Section: Applications Of Ha-based Nanoparticlesmentioning

confidence: 99%

Hyaluronan-Based Nanofibers: Fabrication, Characterization and Application

et al. 2019

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“…The enrichment of nanoparticles at tumor site has essential roles in the therapeutic efficacy so that using imaging technique to aid in determining the right treatment time is important . Due to the PPy core and loading of PFH, the PTC‐siRNA/PFH platform is expected to possess both PA imaging and contrast‐enhanced US imaging ability.…”

Section: Resultsmentioning

confidence: 99%

A Yolk–Shell Nanoplatform for Gene‐Silencing‐Enhanced Photolytic Ablation of Cancer

Guo

Tian

Yang

et al. 2018

Adv Funct Materials

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Noninvasive near-infrared (NIR) light responsive therapy is a promising cancer treatment modality; however, some inherent drawbacks of conventional phototherapy heavily restrict its application in clinic. Rather than producing heat or reactive oxygen species in conventional NIR treatment, here a multifunctional yolk-shell nanoplatform is proposed that is able to generate microbubbles to destruct cancer cells upon NIR laser irradiation. Besides, the therapeutic effect is highly improved through the coalition of small interfering RNA (siRNA), which is codelivered by the nanoplatform. In vitro experiments demonstrate that siRNA significantly inhibits expression of protective proteins and reduces the tolerance of cancer cells to bubble-induced environmental damage. In this way, higher cytotoxicity is achieved by utilizing the yolk-shell nanoparticles than treated with the same nanoparticles missing siRNA under NIR laser irradiation. After surface modification with polyethylene glycol and transferrin, the yolk-shell nanoparticles can target tumors selectively, as demonstrated from the photoacoustic and ultrasonic imaging in vivo. The yolkshell nanoplatform shows outstanding tumor regression with minimal side effects under NIR laser irradiation. Therefore, the multifunctional nanoparticles that combining bubble-induced mechanical effect with RNA interference are expected to be an effective NIR light responsive oncotherapy.

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“…By taking ratiometric measurement, the hypoxic tissue environment ( e.g ., tumor and ischemia) can be imaged. (3) Aiming to improve the theranostic efficiency in personalized medicine, the third strategy focuses on developing contrast agents that have simultaneous functionalities of imaging and therapy ( e.g ., photothermal, photodynamic, drug delivery) [78, 82, 103–106]. Cheng et al demonstrated PEGylated nanosheets for dual-modal CT/PAT guided photothermal therapy of tumors [103].…”

Section: Advances In Molecular Probes Made For Patmentioning

confidence: 99%

Recent progress in photoacoustic molecular imaging

Yao

Wang

2018

Current Opinion in Chemical Biology

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By acoustically detecting the optical absorption contrast, photoacoustic (PA) tomography (PAT) has broken the penetration limits of traditional high-resolution optical imaging. Through spectroscopic analysis of the target's optical absorption, PAT can identify a wealth of endogenous and exogenous molecules and thus is inherently capable of molecular imaging with high sensitivity. PAT's molecular sensitivity is uniquely accompanied by non-ionizing radiation, high spatial resolution, and deep penetration in biological tissues, which other optical imaging modalities cannot achieve yet. In this concise review, we summarize the most recent technological advancements in PA molecular imaging and highlight the novel molecular probes specifically made for PAT in deep tissues. We conclude with a brief discussion of the opportunities for future advancements.

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Activatable near infrared dye conjugated hyaluronic acid based nanoparticles as a targeted theranostic agent for enhanced fluorescence/CT/photoacoustic imaging guided photothermal therapy

Cited by 111 publications

References 76 publications

Hyaluronan-Based Nanofibers: Fabrication, Characterization and Application

Hyaluronan-Based Nanofibers: Fabrication, Characterization and Application

A Yolk–Shell Nanoplatform for Gene‐Silencing‐Enhanced Photolytic Ablation of Cancer

Recent progress in photoacoustic molecular imaging

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