Activatable photothermal agents with target-initiated large spectral separation for highly effective reduction of side effects

Abstract

Activatable photothermal reagents were designed for cancer therapy. Dual-site-activatable probe showed a large spectral redshift of 150 nm in the presence of H2O2, achieving truly selective activation to minimize side effects during PTT of cancers.

Depletion and Downregulation of Hydrogen Sulfide Using an Activatable Probe for Promoting Photothermal Therapy toward Colorectal Cancers

“…The synthesis of AZA-BOD-2 refers to our previous work. 57 1 13 C NMR (101 MHz, CDCl 3 ): δ 159.91, 159. 19, 153.10, 152.36, 146.48, 143.43, 142.96, 138.95, 132.34, 130.91, 125.40, 118.05, 114.55, 111.79 Preparation of AZA-NPs.…”

Engineering organelle-specific activatable molecules for ultra-fast and reliable in situ mapping of subcellular nitric oxide

“…[44][45][46][47] BODIPY fluorescent dyes have the advantages of good photostability, insensitivity to pH, and high fluorescence quantum yields. [48][49][50][51][52] We expected to construct a generalized platform that could reduce the reaction time of the probe and improve its detection sensitivity, enabling in situ and high-fidelity imaging of NO within various organelles. As shown in Schemes 1 and 2, taking the ER and lysosome as examples, in order to enable subcellular targeting of probes, we constructed ER-targeting BODIPY luminogens (ER-BOD) and lysosome-targeting BODIPY luminogens (Lyso-BOD), respectively.…”

Activatable BODIPY-chromene NIR-II probes with small spectral crosstalk enable high-contrast in vivo bioimaging

“…This spectral crosstalk between NIR-II probes and the corresponding products often causes a high initial absorption value at their excitation wavelength. 7,8 It is likely that the initial ''off'' state of the probes still produces significant background fluorescence, resulting in a low SBR with a small Stokes shift. [9][10][11][12] Therefore, it is an urgent demand in the development of an innovative NIR-II fluorophore scaffold to construct activatable probes with small spectral crosstalk for facilitating high SBR in vivo bioimaging.…”