Activated gamma/delta T lymphocytes infiltrating renal cell carcinoma

Kowalczyk, Dariusz W.; Skorupski, Witold; Kwias, Zbigniew; Nowak, Jerzy

doi:10.1016/0165-2478(96)02605-3

Cited by 18 publications

(12 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This result was also in accordance with the low levels of intratumoral γδ T cells in other solid tumors, such as renal cancer (Kowalczyk et al, 1996;Inman et al, 2008). In the tumoral tissues, we found that the number of γδ T cells was positively associated with OS when patients were defined as following subgroups: patients with earlystage (BCLC stage A) HCC, or with single tumor, or with well differentiated tumor, or without thrombi, which indicated that the important antitumor role of γδ T cells in early-stage HCC.…”

Section: Discussionsupporting

confidence: 72%

Low Counts of γδ T Cells in Peritumoral Liver Tissue are Related to More Frequent Recurrence in Patients with Hepatocellular Carcinoma after Curative Resection

Cai

Wang²,

Yi³

et al. 2014

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 72%

Low Counts of γδ T Cells in Peritumoral Liver Tissue are Related to More Frequent Recurrence in Patients with Hepatocellular Carcinoma after Curative Resection

Cai

Wang²,

Yi³

et al. 2014

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

“…CD8 cells, which can destroy tumour cells, have been studied for over two decades. [15][16][17][18] Our previous studies characterized the genomic expression profiles of the CD3 cells obtained from TILs. 8 In this study, CD8 cells from TILs obtained from the same liver cancer specimens were analysed for gene expression profiles.…”

Section: Discussionmentioning

confidence: 99%

Genomic expression analysis by single‐cell mRNA differential display of quiescent CD8 T cells from tumour‐infiltrating lymphocytes obtained from in vivo liver tumours

Zhang

Ding

et al. 2009

Immunology

View full text Add to dashboard Cite

Summary We performed a genomic study combining single‐cell mRNA differential display and RNA subtractive hybridization to elucidate CD8 T‐cell quiescence/ignorance. By comparing actively maintained quiescent CD8 T cells from liver tumour tumour‐infiltrating lymphocytes (TILs) with quiescent T cells at the single‐cell level, we identified differentially expressed candidate genes by high‐throughput screening and comparative analysis of expressed sequence tags (ESTs). While genes for the T‐cell receptor, tumour necrosis factor (TNF) receptor, TNF‐related apoptpsis inducing ligand (TRAIL) and perforin were down‐regulated, key genes such as Tob, transforming growth factor (TGF)‐β, lung Krüpple‐like factor (LKLF), Sno‐A, Ski, Myc, Ets‐2 repressor factor (ERF) and RE1‐silencing transcription factor (REST/NRSF) complex were highly expressed in the quiescent TIL CD8 cells. Real‐time polymerase chain reaction (PCR) further confirmed these results. A regulation model is proposed for actively maintained quiescence in CD8 T cells, including three components: up‐regulation of the TGF‐β pathway, a shift in the MYC web and inhibition of the cell cycle.

show abstract

“…The rationale for this approach has been primarily predicated on: 1) a reported relative abundance of ␥␦ T cells in the mononuclear cell infiltrates of RCC tumors (7), 2) associations of ␥␦ T cells with some pathologic features of RCC and (8), and 3) demonstrations that ␥␦ T cells stimulated with pyrophosphate derivatives exhibit cytolytic activity against RCC target cells ex vivo (4,7). Of concern, however, is that much of the impetus for clinical trial testing of ␥␦ T cell adoptive immunotherapy has been provided by way of indirect immunologic studies (5,6), typically involving very small numbers of patient tumor specimens and often without consideration of RCC tumor subtype (4,(7)(8)(9)(10).…”

mentioning

confidence: 99%

Questionable Relevance of γδ T Lymphocytes in Renal Cell Carcinoma

Inman¹,

Frigola²,

Harris³

et al. 2008

The Journal of Immunology

View full text Add to dashboard Cite

Adoptive γδ T cell immunotherapy has moved briskly into clinical trials prompted by several small studies suggesting abundant accumulation of γδ T cells within renal cell carcinoma (RCC). In this study, we re-examined levels of γδ T cells within RCC tumors and correlated levels of these cells with pathologic features and outcome associated with this form of cancer. Tissues from 248 consecutive clear cell RCC tumors obtained from 2000 to 2003 were stained and quantified for total CD3+ and γδ T cells per mm2. Wilcoxon rank sum and Kruskal-Wallis tests were used to evaluate associations between T cell amounts and prognostic factors (age, gender, tumor size, stage, grade, tumor necrosis). Cox models were used to assess associations with RCC-specific death. Median numbers of total CD3+ and γδ T cells were 281/mm2 (interquartile range (IQR): 149–536) and 2.6/mm2 (IQR: 1.3–4.6), respectively. The median percentage of CD3+ T cells that were γδ T cells was 1.0% (IQR: 0.4–1.9). This low percentage of intratumoral γδ T cells was diluted even further with rising CD3+ T cell infiltration. Percentages of γδ T cells were not associated with even one single clinicopathologic feature examined. Median follow-up for this study was 3.1 years (48 patients died of RCC) and Cox analysis failed to demonstrate that γδ T cells (hazard ratio = 1.02, p = 0.25) were predictive of RCC-specific death. γδ T cells are rare and not recruited nor expanded within RCC tumors. Percentages of γδ T cells fail to correlate with any prognostic features of RCC nor specific death. As such, the role of γδ T cells in RCC immunobiology remains questionable.

show abstract

Activated gamma/delta T lymphocytes infiltrating renal cell carcinoma

Cited by 18 publications

References 21 publications

Low Counts of γδ T Cells in Peritumoral Liver Tissue are Related to More Frequent Recurrence in Patients with Hepatocellular Carcinoma after Curative Resection

Low Counts of γδ T Cells in Peritumoral Liver Tissue are Related to More Frequent Recurrence in Patients with Hepatocellular Carcinoma after Curative Resection

Genomic expression analysis by single‐cell mRNA differential display of quiescent CD8 T cells from tumour‐infiltrating lymphocytes obtained from in vivo liver tumours

Questionable Relevance of γδ T Lymphocytes in Renal Cell Carcinoma

Contact Info

Product

Resources

About