Activation of antigen-specific suppressor T cells by B cells from mice immunized with type III pneumococcal polysaccharide.

Taylor, Christopher E.; Stashak, Philip W.; Caldes, George; Prescott, Benjamin; Chused, Thomas E.; Brooks, Ada; Baker, Phillip J.

doi:10.1084/jem.158.3.703

Cited by 58 publications

(33 citation statements)

References 23 publications

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“…It has long been established in mice [1][2][3] that Ihc antibody response to T-cell independent type 2 (TI-2} antigens is determined by the activities of two functionally distinct types of regulatory T cells with opposing functions. On the one hand amplifier T cells have been delineated which can enhance an antibody response [I.…”

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confidence: 99%

The Human in Vitro Anti‐type 4 Pneumococcal Polysaccharide Antibody Response is Regulated by Suppressor T Cells

et al. 1991

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In order to study the regulation of the human B-cell response to T-cell independent type 2 (TI-2) antigens, we analysed the role of T cells in the in vitro antibody response to type 4 pneumococcal polysaccharide (PS4). We found that T cells can positively regulate the in vitro antibody response to PS4 when they are added into an in vitro B-cell culture system. In addition we demonstrated that T cells exert a negatively regulating activity. We found that T cells, when cultured for 24 h in the presence of high concentrations of PS4, can suppress the anti-PS4 antibody response. This down-regulation of the anti-PS4 B-cell response is shown to be antigen specific and MHC-restricted. Furthermore, PS4-specific T-cell mediated suppression appears to be radioresistant and confined to the T-cell preparations enriched for CD8+ cells. The results show that analogous to results obtained in mice, human T cells are able to exert a regulatory control of the antibody response to TI-2 antigens.

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confidence: 99%

The Human in Vitro Anti‐type 4 Pneumococcal Polysaccharide Antibody Response is Regulated by Suppressor T Cells

et al. 1991

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“…Pneumococcal capsuiar polysaecharide antigens are often employed in the study of the immune response against polysaccharides in animals as well as in humans [1,3,10]. In vitro studies have suggested that the B-cell response in humans-as in mice \2, 4,8,9]-is T-cell independent; it is, however, probably regulated by T cells [3,16,19,20].…”

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Vaccination‐Induced Circulation of Human B Cells Secreting Type‐Specific Antibodies against Pneumococcal Polysaccharides

1987

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Indirect plaque-forming cell assays detecting B cells secreting antibodies against capsular pneumococcal polysaccharide (PPS) antigens are described. In healthy adult volunteers the total number of B cells secreting IgM antibodies against the antigens in a polyvalent PPS vaccine reached a maximum in the blood 6 days after in vivo immunization (mean: 552/10(6) mononuclear cells), whereas the highest concentration of IgG and IgA antibody-secreting cells (SC) were detected 7 days after immunization (means: 628 and 1691/10(6]. B cells secreting antibodies to PPS type 3 (PPS3), PPS8, PPS18C and C-polysaccharide (CPS)--a cell wall antigen common to all pneumococci--constituted 9%, 16%, 6% and 5% (means) of the total number of antibody SC respectively. While the majority of the anti-PPS-SC secreted IgA antibodies, the anti-CPS-SC almost exclusively secreted IgG. Pre-vaccination concentrations of anti-PPS were generally low in contrast to antibodies against CPS, which were present in high concentrations in all individuals. The discrepancy in the Ig class of the antibody SC is probably related to the difference in the pre-vaccination immunity against PPS and CPS.

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“…18], and Taylor et ut. [21] give evidence for the induction of anti-anti-SSSIII-specific suppressor cells as the result of immunization. In further experiments we have separated, with high performanee ion exehange…”

Section: Discussionmentioning

confidence: 93%

The Immune Response to Pneumococcal Polysaccharide Type III is Followed by Increased Production of an Antibody Antifactor

Pasanen

1986

Scand J Immunol

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The study shows that serum from pneumococcal polysaccharide type III (SSSIII)-immunized and nonimmunized mice that has been absorbed until devoid of anti-SSSIII antibodies inhibits anti-SSSIII plaque-forming cells (PFC) but not antisheep red blood PFC in antibody plaque assay. A large fraction of the inhibitions activity can be absorbed by and eluted from anti-SSSIII-Sepharose, but not normal mouse serum-Sepharose. It has low or no affinity for protein A and concanavalin A. The titre of the inhibitor increases with repeated immunizations and inhibits the anti-SSSIII PFC of rats or mice of different allotypes. On the basis of these characteristics, I classify the inhibitor as an anti-idiotypic nonimmunoglobulin factor directed against a common determinant of anti-SSSIII antibodies of mouse and rat, with an immuno-regulatory function.

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Activation of antigen-specific suppressor T cells by B cells from mice immunized with type III pneumococcal polysaccharide.

Cited by 58 publications

References 23 publications

The Human in Vitro Anti‐type 4 Pneumococcal Polysaccharide Antibody Response is Regulated by Suppressor T Cells

The Human in Vitro Anti‐type 4 Pneumococcal Polysaccharide Antibody Response is Regulated by Suppressor T Cells

Vaccination‐Induced Circulation of Human B Cells Secreting Type‐Specific Antibodies against Pneumococcal Polysaccharides

The Immune Response to Pneumococcal Polysaccharide Type III is Followed by Increased Production of an Antibody Antifactor

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