Activation of ascending antinociceptive system by vagal afferent input as revealed in the nucleus ventralis posteromedialis

Nishikawa, Yasuo; Koyama, Natsu; Yoshida, Yo; Yokota, Toshikatsu

doi:10.1016/s0006-8993(99)01521-8

Cited by 34 publications

(25 citation statements)

References 13 publications

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“…structures), could increase or decrease the pain signals. Vagus nerve stimulation produces inhibitions in the trigeminothalamic projection neurons from the TNC [58] and in tooth pulp-responsive units (trigeminal) in ventroposteromedial nucleus of the thalamus [59,60]. Lowintensity stimulations of cervical vagal afferents facilitate nociceptive reflexes such as the jaw-opening reflex [61] or the tail-flick reflex [62].…”

Section: Autonomic-trigeminocervical Connectionsmentioning

confidence: 99%

“…This showed that VNS stimulation significantly inhibits activation of second-order nociceptors in the TNC and pain-related behavior on the side of the facial nociceptive stimulus during the early and late phase. Vagal afferent stimulation predominantly inhibits sensory processing in the TNC [58,65] and in the ventral posteromedial thalamic nucleus [59] (Fig. 2).…”

Section: Autonomic-trigeminocervical Connectionsmentioning

confidence: 99%

See 1 more Smart Citation

Convergence of cervical and trigeminal sensory afferents

Piovesan¹,

Kowacs²,

Oshinsky³

2003

Current Science Inc

141

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Cranial nociceptive perception shows a distinct topographic distribution, with the trigeminal nerve receiving sensory information from the anterior portions of the head, the greater occipital nerve, and branches of the upper cervical roots in the posterior regions. However, this distribution is not respected during headache attacks, even if the etiology of the headache is specific for only one nerve. Nociceptive information from the trigeminal and cervical territories activates the neurons in the trigeminal nucleus caudalis that extend to the C2 spinal segment and lateral cervical nucleus in the dorsolateral cervical area. These neurons are classified as multimodal because they receive sensory information from more than one afferent type. Clinically, trigeminal activation produces symptoms in the trigeminal and cervical territory and cervical activation produces symptoms in the cervical and trigeminal territory. The overlap between the trigeminal nerve and cervical is known as a convergence mechanism. For some time, convergence mechanisms were thought to be secondary to clinical observations. However, animal studies and clinical evidence have expanded our knowledge of convergence mechanisms. In this paper, the role of convergence mechanisms in nociceptive physiology, physiopathology of the headaches, clinical diagnosis, and therapeutic conduct are reviewed.

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Section: Autonomic-trigeminocervical Connectionsmentioning

confidence: 99%

Section: Autonomic-trigeminocervical Connectionsmentioning

confidence: 99%

Convergence of cervical and trigeminal sensory afferents

Piovesan¹,

Kowacs²,

Oshinsky³

2003

Current Science Inc

141

View full text Add to dashboard Cite

show abstract

“…In addition, the vagal afferent stimulation has been found to suppress the spike frequency and c-fos expression occurring in trigeminal and trigeminothalamic neurons in response to noxious orofacial stimulation (Bossut and Maixner, 1996;Bohotin et al, 2003b). Furthermore, the VNS-induced inhibition of activity of tooth pulp-responsive units in the trigeminal nuclei oralis and caudalis (Takeda et al, 1998;Tanimoto et al, 2002), as well as in the ventral posteromedial nucleus of the thalamus (Nishikawa et al, 1999) has been reported.…”

Section: Introductionmentioning

confidence: 96%

Vagal afferent modulation of spinal trigeminal neuronal responses to dural electrical stimulation in rats

2012

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“…Vagal afferent Fig. 1 Cutaneous lesion of the stimulated area in the anterior aspect of the neck due to prolonged finger pressure stimulation predominantly inhibits sensory processing in the TNC [6] and in the ventral posteromedial thalamic nucleus [7].…”

Section: Discussionmentioning

confidence: 99%