Activation of cytokine expression occurs through the TNFα/NF-κB-mediated pathway in birnavirus-infected cells

Wang, Wei Lun; Liu, Wangta; Gong, Hong‐Yi; Hong, Jiann Ruey; Lin, Ching Chun; Wu, Jen Leih

doi:10.1016/j.fsi.2011.01.015

Cited by 38 publications

(19 citation statements)

References 49 publications

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“…With respect to the tumor necrosis factor (tnf) family of pro-inflammatory cytokines, many changes were induced in tnf-related gene transcripts (9 probes with folds >2) in head kidney during oral VP2 vaccination (Fig. 6 down), similarly to what has been described for tnfa and tnfb during IPNV infection in fish cells [40].…”

Section: Genessupporting

confidence: 60%

Oral immunization of rainbow trout to infectious pancreatic necrosis virus (Ipnv) induces different immune gene expression profiles in head kidney and pyloric ceca

Ballesteros

Saint-Jean

Encinas

et al. 2012

Fish & Shellfish Immunology

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Section: Genessupporting

confidence: 60%

Oral immunization of rainbow trout to infectious pancreatic necrosis virus (Ipnv) induces different immune gene expression profiles in head kidney and pyloric ceca

Ballesteros

Saint-Jean

Encinas

et al. 2012

Fish & Shellfish Immunology

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“…The results described here demonstrate that all Gd compounds examined were capable of inducing expression of genes associated with TLR signalling, including XIAP, which activates NF-κB expression in response to TGF-β signalling [30], and of IRF-1, IRF-4 and IRF-9, which are components of downstream intracellular signalling complexes mediating NF-κB target gene regulation and induction of type I IFN expression [31][32][33][34]. Interestingly, exposure to all Gd compounds tested resulted in a striking induction of the expression of type I IFN-responsive genes CCL20, IFI44L, IFIT, IL-8, IL-18 and IRG1.…”

Section: +mentioning

confidence: 75%

Induction of a type I interferon signature in normal human monocytes by gadolinium-based contrast agents: comparison of linear and macrocyclic agents

Wermuth

Jimenez

2013

Clinical and Experimental Immunology

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SummaryThe gadolinium-based contrast agent (GdBCA) Omniscan activates human macrophages through Toll-like receptor (TLR)-4 and TLR-7 signalling. To explore the mechanisms responsible we compared the ability of linear and macrocyclic GdBCA to induce a type I interferon signature and a proinflammatory/profibrotic phenotype in normal human monocytes in vitro. Expression of genes associated with type I interferon signalling and inflammation and production of their corresponding proteins were determined. Both linear and macrocyclic GdBCA stimulated expression of multiple type I interferon-regulated genes and the expression of numerous chemokines, cytokines and growth factors in normal human peripheral blood monocytes. There was no correlation between the magnitude of the measured response and the Gd chelate used. To explore the mechanisms responsible for GdBCA induction of fibrosis in nephrogenic systemic fibrosis (NSF) in vitro, normal human dermal fibroblasts were incubated with GdBCA-treated monocyte culture supernatants and the effects on profibrotic gene expression were examined. Supernatants from monocytes exposed to all GdBCA stimulated types I and III collagen, fibronectin and α-smooth muscle actin (α-SMA) expression in normal dermal fibroblasts. The results indicate that the monocyte activation induced by GdBCA may be the initial step in the development of GdBCA associated fibrosis in NSF.

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“…Consequently with this key position, nfkb have been described as a viral target for shutoff in mammalian viral infections such as herpes [42], poliovirus [43] and rhabdovirus [44]. Shutoff of nfkb has been also reported in salmonid birnavirus infections [45] and in zebrafish after activation of tlr4 [46]. …”

Section: Resultsmentioning

confidence: 99%

Identification of Multipath Genes Differentially Expressed in Pathway-Targeted Microarrays in Zebrafish Infected and Surviving Spring Viremia Carp Virus (SVCV) Suggest Preventive Drug Candidates

et al. 2013

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Spring viremia carp virus (SVCV) is a rhabdovirus seasonally affecting warm-water cyprinid fish farming causing high impacts in worldwide economy. Because of the lack of effective preventive treatments, the identification of multipath genes involved in SVCV infection might be an alternative to explore the possibilities of using drugs for seasonal prevention of this fish disease. Because the zebrafish (Danio rerio) is a cyprinid susceptible to SVCV and their genetics and genome sequence are well advanced, it has been chosen as a model for SVCV infections. We have used newly designed pathway-targeted microarrays 3-4-fold enriched for immune/infection functional-relevant probes by using zebrafish orthologous to human genes from selected pathways of the Kyoto Encyclopedia of Genes and Genomes (KEGG). The comparative analysis of differential expression of genes through 20 pathways in 2-day exposed or 30-day survivors of SVCV infection allowed the identification of 16 multipath genes common to more than 6 pathways. In addition, receptors (Toll-like, B-cell, T-cell, RIG1-like) as well as viral RNA infection pathways were identified as the most important human-like pathways targeted by SVCV infection. Furthermore, by using bioinformatic tools to compare the promoter sequences corresponding to up and downregulated multipath gene groups, we identified putative common transcription factors which might be controlling such responses in a coordinated manner. Possible drug candidates to be tested in fish, can be identified now through search of data bases among those associated with the human orthologous to the zebrafish multipath genes. With the use of pathway-targeted microarrays, we identified some of the most important genes and transcription factors which might be implicated in viral shutoff and/or host survival responses after SVCV infection. These results could contribute to develop novel drug-based prevention methods and consolidate the zebrafish/SVCV as a model for vertebrate viral diseases.

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Activation of cytokine expression occurs through the TNFα/NF-κB-mediated pathway in birnavirus-infected cells

Cited by 38 publications

References 49 publications

Oral immunization of rainbow trout to infectious pancreatic necrosis virus (Ipnv) induces different immune gene expression profiles in head kidney and pyloric ceca

Oral immunization of rainbow trout to infectious pancreatic necrosis virus (Ipnv) induces different immune gene expression profiles in head kidney and pyloric ceca

Induction of a type I interferon signature in normal human monocytes by gadolinium-based contrast agents: comparison of linear and macrocyclic agents

Identification of Multipath Genes Differentially Expressed in Pathway-Targeted Microarrays in Zebrafish Infected and Surviving Spring Viremia Carp Virus (SVCV) Suggest Preventive Drug Candidates

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