Activation of G-protein-coupled receptor 30 is sufficient to enhance spatial recognition memory in ovariectomized rats

Activation of the G protein-coupled estrogen receptor, but not estrogen receptor α or β, rapidly enhances social learning

“…When administered chronically to OVX rats, G1 enhanced spatial recognition in a Y-maze task (Hawley et al, 2014) and restored impaired performance of OVX rats to that of gonadally intact females on a delayed matching-to-position task (Hammond et al, 2009). In the same task, gonadally intact females treated chronically with a GPER1 antagonist took longer to learn the task than vehicle controls (Hammond et al, 2012).…”

Rapid effects of the G-protein coupled oestrogen receptor (GPER) on learning and dorsal hippocampus dendritic spines in female mice

“…In the same DMP task, treatment with the GPER antagonist, G-15, impaired spatial learning in ovariectomized and gonadally intact rats treated with estradiol [13]. Additionally, Physiology & Behavior 149 (2015) 53-60 short-term treatment with G-1, 24 and 48 h before acquisition of a spatial task, improved spatial recognition learning in ovariectomized rats when tested 48 h later [14].…”

Epigenetic regulation of estrogen-dependent memory

“…GPER is the most well studied of these receptors, and has been identified within hippocampal dendritic spines and in hippocampally-projecting basal forebrain cholinergic neurons (Hammond and Gibbs, 2011; Hammond et al, 2011; Srivastava and Evans, 2013). GPER activation reportedly facilitates spatial memory consolidation in female rats (Hammond and Gibbs, 2011; Hammond et al, 2012; Hawley et al, 2014), although the molecular mechanisms underlying this effect remain unknown.…”