Activation of kinin B1 receptor increases the release of metalloproteases-2 and -9 from both estrogen-sensitive and -insensitive breast cancer cells

Ehrenfeld, Pamela; Conejeros, Iván; Pavicic, María Francisca; Matus, Carola E.; González, Carlos B.; Quest, Andrew F. G.; Bhoola, K. D.; Poblete, María Teresa; Burgos, Rafael A.; Figueroa, Carlos D.

doi:10.1016/j.canlet.2010.09.020

Cited by 47 publications

(53 citation statements)

References 51 publications

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“…MMP-9 is induced by adhesion molecules, mainly activated integrins, cytokines and growth factors (Beliveau et al, 2010;Zhao and Benveniste, 2008). As an example, cell binding to vitronectin or fibronectin trigger MMP-9 expression, IL-1b, TNF-a or TGF-b induce MMP-9 in a autocrine and paracrine fashion, EGF release or the aberrant activation of the EGFR result in over-expression of MMP-9 (Coulson-Thomas et al, 2010;Ehrenfeld et al, 2011;Ikari et al, 2011;Lin et al, 2009;Yu and Stamenkovic, 2000).…”

Section: Biological Aspectsmentioning

confidence: 99%

Human matrix metalloproteinases: An ubiquitarian class of enzymes involved in several pathological processes

Sbardella

Fasciglione

Gioia

et al. 2012

Molecular Aspects of Medicine

210

212

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a b s t r a c tHuman matrix metalloproteinases (MMPs) belong to the M10 family of the MA clan of endopeptidases. They are ubiquitarian enzymes, structurally characterized by an active site where a Zn 2+ atom, coordinated by three histidines, plays the catalytic role, assisted by a glutamic acid as a general base. Various MMPs display different domain composition, which is very important for macromolecular substrates recognition. Substrate specificity is very different among MMPs, being often associated to their cellular compartmentalization and/or cellular type where they are expressed. An extensive review of the different MMPs structural and functional features is integrated with their pathological role in several types of diseases, spanning from cancer to cardiovascular diseases and to neurodegeneration. It emerges a very complex and crucial role played by these enzymes in many physiological and pathological processes.

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Section: Biological Aspectsmentioning

confidence: 99%

Human matrix metalloproteinases: An ubiquitarian class of enzymes involved in several pathological processes

Sbardella

Fasciglione

Gioia

et al. 2012

Molecular Aspects of Medicine

210

212

View full text Add to dashboard Cite

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“…For example, B1R induction is part of the proinflammatory phenotype promoted by low laminar shear stress and may participate in responses including vasodilatation and leukocyte recruitment in atherogenesis [8]. Furthermore, B1R is coupled to both proliferation [9] and the release of metaloproteinases in breast cancer cells [10] suggesting an involvement in cancer cell invasiveness. Thus, B1R is a promising therapeutic target in both renal and cardiovascular disease [11] and cancer [12].…”

Section: Introductionmentioning

confidence: 99%

Kinin B1 receptor homo-oligomerization is required for receptor trafficking to the cell surface

Sandén

Leeb-Lundberg

2013

International Immunopharmacology

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Kinin B1 receptor homo-oligomerization is required for receptor trafficking to the cell surface.Sandén, Caroline; Leeb-Lundberg, Fredrik , & Leeb-Lundberg, F. (2012). Kinin B1 receptor homo-oligomerization is required for receptor trafficking to the cell surface. International Immunopharmacology, 15(1), 121-128. DOI: 10.1016121-128. DOI: 10. /j.intimp.2012 General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.• Users may download and print one copy of any publication from the public portal for the purpose of private study or research.• You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal We conclude that B1R homo-oligomerization is necessary for B1R maturation and trafficking to the cell surface. Modulating this mechanism may be a novel therapeutic avenue in inflammatory disease.

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“…We have also reported that release of metalloproteases in MCF-7 and MDA-MB-231 breast cancer cells was blocked by AG1478, an observation that was confirmed by transfection of breast cancer cells with the dominant negative EGFR mutant HERCD533 (Ehrenfeld et al, 2011). The transactivation mechanism involved in EGFR activation by B1R agonists has not been elucidated yet, but work performed by our group in human HaCaT keratinocytes, MCF-7 breast cancer cell has visualized that B1R stimulation produces Src phosphorylation, that is blocked by the specific Src inhibitor, PP2 (Figs.…”

Section: Mechanisms Of Egfr Transactivation By Kinin B1 Receptormentioning

confidence: 54%

“…Moreover, it is known that release of the kinin moiety from kininogens sited on the neutrophil surface by enzymatic action of the classical tissue kallikrein (hK1) results in opening of junctions between the endothelial cells, thereby causing plasma extravasation (Stuardo et al, 2004). B1R modulates the release of matrix metalloproteases from both human neutrophils ) and breast cancer cells (Ehrenfeld et al, 2011), an event that may contribute to the extracellular matrix remodeling in processes such as inflammation, wound healing and cancer. Part of the effects produced by B1R in neutrophils and cancer cells include activation of ERK1/2 and p38 MAPK and transactivation of EGFR in breast cancer cells, an event that usually results in the activation of MAPK.…”

Section: Wwwintechopencommentioning

confidence: 99%

Signaling Pathways Coupled to Activation of the Kinin B1 Receptor

Ehrenfeld¹,

Figueroa²,

Bhoola³

et al. 2012

Advances in Protein Kinases

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Activation of kinin B1 receptor increases the release of metalloproteases-2 and -9 from both estrogen-sensitive and -insensitive breast cancer cells

Cited by 47 publications

References 51 publications

Human matrix metalloproteinases: An ubiquitarian class of enzymes involved in several pathological processes

Human matrix metalloproteinases: An ubiquitarian class of enzymes involved in several pathological processes

Kinin B1 receptor homo-oligomerization is required for receptor trafficking to the cell surface

Signaling Pathways Coupled to Activation of the Kinin B1 Receptor

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